Fluorescent X-Ray Computed Tomography Using Synchrotron Radiation Towards Molecular Imaging

Yuasa, Tetsuya; Takeda, Takeshi

doi:10.5772/30550

Cited by 1 publication

(1 citation statement)

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“…Projection images of the spatial distribution of a high-Z tracer material are then recorded by scanning the pencil beam over the object along two dimensions as indicated by the x-and y-axis in figure 2. In addition to that, by a combination of translation and rotation steps, it is also possible to reconstruct images of the tracer distribution for slices through the object resembling the image creation of first generation CT (Shepp andVardi 1982, Yuasa andTakeda 2012). Furthermore, the information of the attenuation of the pencil beam, which can be acquired by a second normal x-ray detector, results in the generation of absorption contrast and thereby simultaneously provides morphological CT-images for in vivo imaging.…”

Section: Proposed Analyzer-based X-ray Fluorescence Imaging Setupmentioning

confidence: 99%

Molecular imaging based on x-ray fluorescent high-Z tracers

et al. 2013

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We propose a novel x-ray fluorescence imaging setup for the in vivo detection of high-Z tracer distributions. The main novel aspect is the use of an analyzer-based, energy-resolved detection method together with a radial, scatter reducing collimator. The aim of this work is to show the feasibility of this method by measuring the Bragg reflected K-fluorescence signal of an iodine solution sample in a proof of principle experiment and to estimate the potential of the complete imaging setup using a Monte Carlo simulation, including a quantification of the minimal detectable tracer concentration for in vivo imaging. The proof of principle experiment shows that even for a small detector area of approximately 7 mm(2), the collimated and Bragg reflected K-fluorescence signal of a sample containing an iodine solution with a concentration of 50 µg ml(-1) can be detected. The Monte Carlo simulation also shows that the proposed x-ray fluorescence imaging setup has the potential to image distributions of high-Z tracers in vivo at a radiation dose of a few mGy and at tracer concentrations down to 1 µg ml(-1) for iodine in small animals.

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Section: Proposed Analyzer-based X-ray Fluorescence Imaging Setupmentioning

confidence: 99%