Fluorescent Visualisation of Oxytocin in the Hypothalamo‐neurohypophysial/‐spinal Pathways After Chronic Inflammation in Oxytocin‐Monomeric Red Fluorescent Protein 1 Transgenic Rats

Matsuura, Takanori; Kawasaki, Makoto; Hashimoto, Hirofumi; Ishikura, Toru; Yoshimura, Mitsuhiro; Ohkubo, Jun‐ichi; Maruyama, Takashi; Motojima, Yasuhito; Sabanai, Ken; Mori, Toshiharu; Ohnishi, Hideo; Sakai, Akinori; Ueta, Yoichi

doi:10.1111/jne.12290

Cited by 29 publications

(42 citation statements)

References 55 publications

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“…In addition, oxytocin, through effects on GABA responses in nociceptive neurons, has an analgesic effect in newborn rat pups during delivery (Mazzuca et al, 2011). There is also evidence of up-regulation of oxytocin in plasma and CNS as well as an analgesic effect in rodent models of inflammatory (Eliava et al, 2016;Matsuura et al, 2015) and neuropathic pain (Gutierrez et al, 2013).…”

Section: The Analgesic Effects Of Oxytocinmentioning

confidence: 99%

“…Intriguingly activity of Clow threshold mechanosensitve afferents (C-LTMs) is integrated with that of nociceptors in lamina I wide dynamic range neurons (Andrew, 2010), the relevance of which will become apparent later. In models of nociceptive and inflammatory pain increased oxytocin expression and evidence of neuronal activation is seen in parvocellular PVN (Matsuura et al, 2016(Matsuura et al, , 2015. Optogenetic activation of parvocellular PVN oxytocin secreting neurons also resulted in analgesia in inflammatory although not neuropathic rodent pain models (Eliava et al, 2016).…”

Section: The Analgesic Effects Of Oxytocinmentioning

confidence: 99%

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C-tactile afferents: Cutaneous mediators of oxytocin release during affiliative tactile interactions?

et al. 2017

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Low intensity, non-noxious, stimulation of cutaneous somatosensory nerves has been shown to trigger oxytocin release and is associated with increased social motivation, plus reduced physiological and behavioural reactivity to stressors. However, to date, little attention has been paid to the specific nature of the mechanosensory nerves which mediate these effects. In recent years, the neuroscientific study of human skin nerves (microneurography studies on single peripheral nerve fibres) has led to the identification and characterisation of a class of touch sensitive nerve fibres named C-Tactile afferents. Neither itch nor pain receptive, these unmyelinated, low threshold mechanoreceptors, found only in hairy skin, respond optimally to low force/velocity stroking touch. Notably, the speed of stroking which c-tactile afferents fire most strongly to is also that which people perceive to be most pleasant. The social touch hypothesis posits that this system of nerves has evolved in mammals to signal the rewarding value of physical contact in nurturing and social interactions. In support of this hypothesis, in this paper we review the evidence that cutaneous stimulation directly targeted to optimally activate c-tactile afferents reduces physiological arousal, carries a positive affective value and, under healthy conditions, inhibits responses to painful stimuli. These effects mirror those, we also review, which have been reported following endogenous release and exogenous administration of oxytocin. Taken together this evidence suggests c-tactile afferent stimulation may mediate oxytocin release during affiliative tactile interactions.

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Section: The Analgesic Effects Of Oxytocinmentioning

confidence: 99%

Section: The Analgesic Effects Of Oxytocinmentioning

confidence: 99%

C-tactile afferents: Cutaneous mediators of oxytocin release during affiliative tactile interactions?

et al. 2017

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“…The method for preparing the tissue specimens with stained sections and the analysis of specimens with microscopy were performed as described previously (7,8,31). The sections were mounted on glass slides and cover-slipped using Vectashield (Vector Laboratories Co. Ltd., CA, USA).…”

Section: Fos Colocalization With Oxt/avpmentioning

confidence: 99%

“…Adjuvant arthritis is a model of poly-arthritis induced by immunogenic adjuvants (complete Freund's adjuvant) (14,15). Our previous studies with the adjuvant arthritis model showed that chronic multiple-arthritis activates the OXT/AVP system separately (7,10). Further, AVP, not corticotropinreleasing hormone (CRH), predominantly activates the HPA axis in chronic multiple-arthritis.…”

Section: Introductionmentioning

confidence: 99%

Acute Mono-Arthritis Activates the Neurohypophysial System and Hypothalamo-Pituitary Adrenal Axis in Rats

et al. 2020

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Various types of acute/chronic nociceptive stimuli cause neuroendocrine responses such as activation of the hypothalamo-neurohypophysial [oxytocin (OXT) and arginine vasopressin (AVP)] system and hypothalamo-pituitary adrenal (HPA) axis. Chronic multiple-arthritis activates the OXT/AVP system, but the effects of acute mono-arthritis on the OXT/AVP system in the same animals has not been simultaneously evaluated. Further, AVP, not corticotropin-releasing hormone (CRH), predominantly activates the HPA axis in chronic multiple-arthritis, but the participation of AVP in HPA axis activation in acute mono-arthritis remains unknown. Therefore, we aimed to simultaneously evaluate the effects of acute mono-arthritis on the activity of the OXT/AVP system and the HPA axis. In the present study, we used an acute mono-arthritic model induced by intra-articular injection of carrageenan in a single knee joint of adult male Wistar rats. Acute mono-arthritis was confirmed by a significant increase in knee diameter in the carrageenan-injected knee and a significant decrease in the mechanical nociceptive threshold in the ipsilateral hind paw. Immunohistochemical analysis revealed that the number of Fos-immunoreactive (ir) cells in the ipsilateral lamina I-II of the dorsal horn was significantly increased, and the percentage of OXT-ir and AVP-ir neurons expressing Fos-ir in both sides of the supraoptic (SON) and paraventricular nuclei (PVN) was increased in acute mono-arthritic rats. in situ hybridization histochemistry revealed that levels of OXT mRNA and AVP hnRNA in the SON and PVN, CRH mRNA in the PVN, and proopiomelanocortin mRNA in the anterior pituitary were also significantly increased in acute mono-arthritic rats. Further, plasma OXT, AVP, and corticosterone levels were significantly increased in acute mono-arthritic rats. These results suggest that acute mono-arthritis activates ipsilateral nociceptive afferent pathways at the spinal level and causes simultaneous and integrative activation of the OXT/AVP system. In addition, the HPA axis is activated by both AVP and CRH in acute mono-arthritis with a distinct pattern compared to that in chronic multiple-arthritis.

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“…For instance, it has been identified in rats that there is significant increase in plasma OT levels at the early stage of sepsis (25), brain OT release following pancreatic injury (26), OT mRNA in adjuvant arthritis (28), and Fos expression in the OSS in advanced cancer (27). Thus, increased OT levels manifest immune disturbance.…”

Section: Immune Functions Of the Ossmentioning

confidence: 99%

Approaches Mediating Oxytocin Regulation of the Immune System

Wang

et al. 2017

Front. Immunol.

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The hypothalamic neuroendocrine system is mainly composed of the neural structures regulating hormone secretion from the pituitary gland and has been considered as the higher regulatory center of the immune system. Recently, the hypothalamo-neurohypophysial system (HNS) emerged as an important component of neuroendocrine–immune network, wherein the oxytocin (OT)-secreting system (OSS) plays an essential role. The OSS, consisting of OT neurons in the supraoptic nucleus, paraventricular nucleus, their several accessory nuclei and associated structures, can integrate neural, endocrine, metabolic, and immune information and plays a pivotal role in the development and functions of the immune system. The OSS can promote the development of thymus and bone marrow, perform immune surveillance, strengthen immune defense, and maintain immune homeostasis. Correspondingly, OT can inhibit inflammation, exert antibiotic-like effect, promote wound healing and regeneration, and suppress stress-associated immune disorders. In this process, the OSS can release OT to act on immune system directly by activating OT receptors or through modulating activities of other hypothalamic–pituitary–immune axes and autonomic nervous system indirectly. However, our understandings of the role of the OSS in neuroendocrine regulation of immune system are largely incomplete, particularly its relationship with other hypothalamic–pituitary–immune axes and the vasopressin-secreting system that coexists with the OSS in the HNS. In addition, it remains unclear about the relationship between the OSS and peripherally produced OT in immune regulation, particularly intrathymic OT that is known to elicit central immunological self-tolerance of T-cells to hypophysial hormones. In this work, we provide a brief review of current knowledge of the features of OSS regulation of the immune system and of potential approaches that mediate OSS coordination of the activities of entire neuroendocrine–immune network.

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Fluorescent Visualisation of Oxytocin in the Hypothalamo‐neurohypophysial/‐spinal Pathways After Chronic Inflammation in Oxytocin‐Monomeric Red Fluorescent Protein 1 Transgenic Rats

Cited by 29 publications

References 55 publications

C-tactile afferents: Cutaneous mediators of oxytocin release during affiliative tactile interactions?

C-tactile afferents: Cutaneous mediators of oxytocin release during affiliative tactile interactions?

Acute Mono-Arthritis Activates the Neurohypophysial System and Hypothalamo-Pituitary Adrenal Axis in Rats

Approaches Mediating Oxytocin Regulation of the Immune System

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