Fluorescent styryl pyridine-N-oxide probes for imaging lipid droplets

Abstract

Sub-cellular imaging with styryl fluorophores: the zwitterion labels lipid droplets and the cation stains mitochondria.

Detecting labile heme and ferroptosis through ‘turn-on’ fluorescence and lipid droplet localization post Fe2+ sensing

“…Previously, we demonstrated the utility of pyridine- N -oxide fluorophores for specific imaging of lipid droplets. 39 These N -oxide probes are designed based on the donor–π–acceptor scaffold. This architecture, with good optoelectronic properties, tunable intramolecular charge transfer emission, and potential synthetic tunability, has been a preferred molecular design for various physical or biological investigations.…”