Fluorescent probes with high pKa values based on traditional, near-infrared rhodamine, and hemicyanine fluorophores for sensitive detection of lysosomal pH variations

Mazi, Wafa; Adhikari, Rashmi; Zhang, Yibin; Xia, Shuai; Fang, Mingxi; Luck, Rudy L.; Tajiri, Momoko; Tiwari, Ashutosh; Tanasova, Marina; Liu, Haiying

doi:10.1016/j.ymeth.2019.07.012

Cited by 13 publications

(5 citation statements)

References 46 publications

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“…After connecting with rhodamine, the advantages of the two fluorophores can be combined and play a greater role. [42][43][44][45]…”

Section: Rhodaminementioning

confidence: 99%

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New insight into the application of fluorescence platforms in tumor diagnosis: From chemical basis to clinical application

Chen²,

Pan

et al. 2022

Medicinal Research Reviews

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Early and rapid diagnosis of tumors is essential for clinical treatment or management. In contrast to conventional means, bioimaging has the potential to accurately locate and diagnose tumors at an early stage. Fluorescent probe has been developed as an ideal tool to visualize tumor sites and to detect biological molecules which provides a requirement for noninvasive, real-time, precise, and specific visualization of structures and complex biochemical processes in vivo. Rencently, the development of synthetic organic chemistry and new materials have facilitated the development of near-infrared small molecular sensing platforms and nanoimaging platforms. This provides a competitive tool for various fields of bioimaging such as biological structure and function imaging, disease diagnosis, in situ at the in vivo level, and real-time dynamic imaging. This review systematically focused on the recent progress of small molecular near-infrared fluorescent probes and nano-fluorescent probes as new biomedical imaging tools in the past 3-5 years, and it covers the application of tumor biomarker sensing, tumor microenvironment imaging, and tumor vascular imaging, intraoperative guidance and as an integrated platform for diagnosis, aiming to provide

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“…After connecting with rhodamine, the advantages of the two fluorophores can be combined and play a greater role. [42][43][44][45]…”

Section: Rhodaminementioning

confidence: 99%

“…Cyanine is an excellent and typical NIR fluorophore. After connecting with rhodamine, the advantages of the two fluorophores can be combined and play a greater role 42–45 …”

Section: Nir Small Molecule Fluorescence Probesmentioning

confidence: 99%

New insight into the application of fluorescence platforms in tumor diagnosis: From chemical basis to clinical application

Chen²,

Pan

et al. 2022

Medicinal Research Reviews

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“…12,13 More crucially, uorescent probes provide direct observation of dynamic information regarding HOCl in live cells, tissues, and animals with great temporal and spatial resolution combined with high resolution confocal microscopy. [14][15][16][17] Towards this end, chemists and biologists have made signicant progress in generating highly specic uorescent probes for visualizing lysosomal HOCl. [18][19][20][21][22] Despite these incredible accomplishments, the majority of the reported HOCl/ClO − probes exhibit poor reactivities, short emission wavelengths, high toxicities, and certain interferences from other ROS/RNS.…”

Section: Introductionmentioning

confidence: 99%

In vivo bioimaging and detection of endogenous hypochlorous acid in lysosome using a near-infrared fluorescent probe

Jiang

Wang

et al. 2023

Anal. Methods

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“…The final section will summarize recent advances in the synthesis and understanding of their structure including novel computational approaches. Even though a lot of progress has been achieved, pH-sensing [60][61][62][63][64], metal ion detection [65][66][67][68][69][70][71][72], and the use of Spirocyclic, xanthene-based probes usually have a hydroxy-or carboxy-moiety or other intramolecular nucleophiles at the 2 position of a pendant aromatic ring at the C-9 -atom of the xanthene core (Scheme 1) [41,42]. This intramolecular nucleophilic-moiety attacks the sp 2 -hybridized C-9 -atom and forms the colorless spirocyclic form.…”

Section: Introductionmentioning

confidence: 99%

“…The final section will summarize recent advances in the synthesis and understanding of their structure including novel computational approaches. Even though a lot of progress has been achieved, pH-sensing [ 60 , 61 , 62 , 63 , 64 ], metal ion detection [ 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 ], and the use of nanoparticles [ 21 , 73 , 74 , 75 , 76 , 77 , 78 ] or any other solid support [ 79 , 80 , 81 , 82 ] will be omitted, given the scope of this review.…”

Section: Introductionmentioning

confidence: 99%

Recent Progress in Small Spirocyclic, Xanthene-Based Fluorescent Probes

2020

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The use of fluorescent probes in a multitude of applications is still an expanding field. This review covers the recent progress made in small molecular, spirocyclic xanthene-based probes containing different heteroatoms (e.g., oxygen, silicon, carbon) in position 10′. After a short introduction, we will focus on applications like the interaction of probes with enzymes and targeted labeling of organelles and proteins, detection of small molecules, as well as their use in therapeutics or diagnostics and super-resolution microscopy. Furthermore, the last part will summarize recent advances in the synthesis and understanding of their structure–behavior relationship including novel computational approaches.

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Fluorescent probes with high pKa values based on traditional, near-infrared rhodamine, and hemicyanine fluorophores for sensitive detection of lysosomal pH variations

Cited by 13 publications

References 46 publications

New insight into the application of fluorescence platforms in tumor diagnosis: From chemical basis to clinical application

New insight into the application of fluorescence platforms in tumor diagnosis: From chemical basis to clinical application

In vivo bioimaging and detection of endogenous hypochlorous acid in lysosome using a near-infrared fluorescent probe

Recent Progress in Small Spirocyclic, Xanthene-Based Fluorescent Probes

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