Fluorescent probes for visualizing ROS-associated proteins in disease

Wang, Hui; Wang, Xin; Li, Ping; Dong, Mingyan; Yao, Shao Q.; Tang, Bo

doi:10.1039/d1sc02165f

Cited by 61 publications

(41 citation statements)

References 187 publications

(241 reference statements)

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“…Compared with other analysis techniques, the fluorescence-based detection technique is one of the most powerful approaches for biological and environmental analysis owing to its selectivity and sensitivity ( Chen et al, 2016 ; Balamurugan et al, 2018 ; Wang et al, 2021 ). The Luo group described a simple approach to construct a label-free fluorescent sensor array based on four nitrogen-doped carbon dots (N-CDs) to achieve simultaneous detection of multiple proteins, as shown in Figure 1B ( Xu et al, 2017 ).…”

Section: Fluorescent Sensor Arraymentioning

confidence: 99%

Optical Sensor Array for the Early Diagnosis of Alzheimer’s Disease

Stewart

Yang

et al. 2022

Front. Chem.

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Alzheimer’s disease (AD) is the most common neurodegenerative disorder and has complicated pathobiology, leading to irreversible memory loss and severe cognitive dysfunction. For patients with AD, the advent of the disease usually occurs after years of pathological changes. The early diagnosis and monitoring of AD are of great significance as the early-stage intervention and treatment may be the most effective. Biomarkers, such as beta-amyloid and tau levels in cerebrospinal fluid (CSF) and brain, offer one of the most promising paths and are combined with neuroimaging and immunological detection for AD diagnosis. However, high expense and radiation of neuroimaging and low sensitivity of immunosorbent assay limited their applications. Meanwhile, the relevance of Aβ peptides and tau proteins to the development of AD remains highly debatable, meaning that detecting one specific biomarker holds limited prospects in achieving early and accurate detection of AD. Optical sensor arrays based on pattern recognition enable the discrimination of multiple analytes in complicated environments and are thus highly advantageous for the detection of AD with multi-biomarkers. In this review, we survey the recent advances of optical sensor arrays for the diagnosis of AD, as well as the remaining challenges.

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Section: Fluorescent Sensor Arraymentioning

confidence: 99%

Optical Sensor Array for the Early Diagnosis of Alzheimer’s Disease

Stewart

Yang

et al. 2022

Front. Chem.

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“…[25][26][27][28][29][30][31][32][33][34][35] In particular, small-molecule fluorescent probes exhibit some unique merits, including facile synthesis and modification, excellent penetration and targeting ability and satisfactory reproducibility. [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] Consequently, numerous small-molecule fluorescent probes have been explosively fabricated to explore ER as well as its corresponding active species in recent years. However, this interesting and frontier topic has not been reviewed systematically so far.…”

Section: Introductionmentioning

confidence: 99%

Recent progress in small-molecule fluorescent probes for endoplasmic reticulum imaging in biological systems

Tang

Zhai

et al. 2022

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“…With the continuous development of imaging technology for modern life sciences, methods involving fluorescence imaging technology based on fluorescent materials 13 have attracted more and more attention in pathogen detection due to their real-time, 14 in situ, high sensitivity and resolution. 15,16 However, most fluorescent probes, including proteins, 17,18 organic molecules and inorganic nanoparticles, [19][20][21] have the disadvantages of photobleaching, toxicity and aggregationcaused quenching (ACQ), resulting in a dramatic drop in their fluorescence signal, as well as limiting the actual working concentration to a very low level and presenting inherent limitations in the development of efficient biological detection probes for microbes. Since Tang's group discovered and proposed the aggregation-induced emission (AIE) behavior of fluorescent materials with specific structures, 22 these have appealed widely to researchers in various fields for the design of optical materials.…”

Section: Introductionmentioning

confidence: 99%