Fluorescent probes for hydrogen sulfide (H2S) and sulfane sulfur and their applications to biological studies

Shimamoto, Kazuhito; Hanaoka, Kenjiro

doi:10.1016/j.niox.2014.11.008

Cited by 44 publications

(18 citation statements)

References 56 publications

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“…Hydrogen sulde (H 2 S) is a crucial gasotransmitter besides nitric oxide and carbon monoxide. 1,2 At normal levels, H 2 S plays important roles in many physiological processes, such as relaxation of vascular smooth muscles, [3][4][5] inhibition of insulin signaling, 6 mediation of neurotransmission, [7][8][9][10] and suppress inammation against oxidative stress. 11,12 Recent studies indicate that H 2 S affects the proliferation of cancer cell in a concentrationdependent manner, and has closely relation with the cancer cell growth.…”

Section: Introductionmentioning

confidence: 99%

A cancer cell-specific two-photon fluorescent probe for imaging hydrogen sulfide in living cells

et al. 2017

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Section: Introductionmentioning

confidence: 99%

A cancer cell-specific two-photon fluorescent probe for imaging hydrogen sulfide in living cells

et al. 2017

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“…SSP2 was successfully applied for sulfane sulfur bioimaging in living cells. Moreover, a few fluorescent probes selective for hydrogen persulfide (H 2 S 2 ) were developed (Shimamoto & Hanaoka, 2015;Takano et al, 2016). Bibli and others (Bibli et al, 2018) have described a LC-MS/MS-based method that uses another probe, SSP4, to detect endogenously generated polysulfides in biological samples.…”

Section: Sulfane Sulfur Quantification In Biological Samplesmentioning

confidence: 99%

Sulfane sulfur – new findings on an old topic

2019

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Sulfane sulfur is a divalent sulfur atom bonded to another sulfur which is very reactive and labile. Compounds containing this reactive sulfur include persulfides, polysulfides, thiosulfate, thiosulfinates, polythionates, and elemental sulfur. Sulfane sulfur appears in a number of biologically important compounds, including thiocysteine, thiocystine and thiotaurine, products of the cysteine metabolism, as well as glutathione persulfide. Sulfane sulfur compounds can modify cysteine residues in proteins via an S-sulfhydration reaction to produce protein persulfides. It has been also postulated that cysteine persulfides can be incorporated into proteins during translation. Recently, the sulfane sulfur compounds, especially the persulfides and polysulfides, have attracted increasing interest due to their regulatory and antioxidant properties. Compounds containing sulfane sulfur are also regarded as a form of H2S storage, which can easily release this gasotransmitter in response to biological signals. Both reactive sulfur species (H2S and sulfane sulfur) always coexist in biological systems. This review is focused on new findings in the field of sulfane sulfur’s biological role, and disruption of its level in some patho/physiological conditions. A few sulfane sulfur donors with potential applications are presented. In recent years, in parallel to increasing interest in biological importance of sulfane sulfur, new analytical methods have been developed for sensitive and reliable determination of its level in the cells and tissues.

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“…This new easy-to-use technology provides immediate H 2 S detection in both living cells and organ tissues (83). It has been found previously that H 2 S itself has reducing ability and is able to change from the oxidation state of sulfur of -2 (H 2 S) to 0 (S) via reducing azide and nitro groups (83). Using this knowledge, novel fluorescent probes have been developed.…”

Section: Fluorescent Probesmentioning

confidence: 99%

Hydrogen Sulfide: A Potential Novel Therapy for the Treatment of Ischemia

Jensen

Drucker

Khaneki

et al. 2017

Shock

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Hydrogen sulfide (H2S) is a novel signaling molecule most recently found to be of fundamental importance in cellular function as a regulator of apoptosis, inflammation, and perfusion. Mechanisms of endogenous H2S signaling are poorly understood; however, signal transmission is thought to occur via persulfidation at reactive cysteine residues on proteins. Although much has been discovered about how H2S is synthesized in the body, less is known about how it is metabolized. Recent studies have discovered a multitude of different targets for H2S therapy, including those related to protein modification, intracellular signaling, and ion channel depolarization. The most difficult part of studying hydrogen sulfide has been finding a way to accurately and reproducibly measure it. The purpose of this review is to: elaborate on the biosynthesis and catabolism of H2S in the human body, review current knowledge of the mechanisms of action of this gas in relation to ischemic injury, define strategies for physiological measurement of H2S in biological systems, and review potential novel therapies that use H2S for treatment.

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Fluorescent probes for hydrogen sulfide (H2S) and sulfane sulfur and their applications to biological studies

Cited by 44 publications

References 56 publications

A cancer cell-specific two-photon fluorescent probe for imaging hydrogen sulfide in living cells

A cancer cell-specific two-photon fluorescent probe for imaging hydrogen sulfide in living cells

Sulfane sulfur – new findings on an old topic

Hydrogen Sulfide: A Potential Novel Therapy for the Treatment of Ischemia

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