Fluorescent probes for ferroptosis bioimaging: advances, challenges, and prospects

Zhan, Jingting; Hu, Qingxia; Huang, Shuhong; Lin, Weiying

doi:10.1039/d2cs00454b

Cited by 66 publications

(29 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…184,185 Versatile fluorescent probes have been prepared to detect and monitor LPO, iron, ROS, and fluctuations in the cellular microenvironment during ferroptosis. 186 Notably, fluorescent probes possess exceptional advantages for the real-time monitoring of drug activity in vivo, which is useful for the therapeutic assessment of ferroptosis inducers on cancer cells. Fluorescent probes extensively applied for the detection of ferroptosis are selectively presented in this section, and their molecular structures are shown in Figure 4.…”

Section: Direct Detectionmentioning

confidence: 99%

Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer

Shi,

Chen,

2024

J. Med. Chem.

View full text Add to dashboard Cite

Ferroptosis is a type of iron-dependent programmed cell death characterized by the dysregulation of iron metabolism and the accumulation of lipid peroxides. This nonapoptotic mode of cell death is implicated in various physiological and pathological processes. Recent findings have underscored its potential as an innovative strategy for cancer treatment, particularly against recalcitrant malignancies that are resistant to conventional therapies. This article focuses on ferroptosis-based therapeutic strategies for precision cancer treatment, covering the molecular mechanisms of ferroptosis, four major types of ferroptosis inducers and their inhibitory effects on diverse carcinomas, the detection of ferroptosis by fluorescent probes, and their implementation in image-guided therapy. These state-of-the-art tactics have manifested enhanced selectivity and efficacy against malignant carcinomas. Given that the administration of ferroptosis in cancer therapy is still at a burgeoning stage, some major challenges and future perspectives are discussed for the clinical translation of ferroptosis into precision cancer treatment. ■ SIGNIFICANCE • The potential of ferroptosis as an innovative strategy for precision cancer therapy is highlighted. • Recent advances are discussed from three perspectives: molecular mechanism and regulation, anti-cancer ferroptosis inducers, and ferroptosis probes for image-guided therapy. • The strengths and weaknesses of ferroptosis modulators and probes are analyzed in terms of current progress and technical barriers. • Future perspectives are emphasized to advance ferroptosis-based therapies toward clinical use for cancer treatment.

show abstract

Section: Direct Detectionmentioning

confidence: 99%

Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer

Shi,

Chen,

2024

J. Med. Chem.

View full text Add to dashboard Cite

show abstract

“…The fusion of optical and clinical imaging, such as MRI, PET, and CT, has the potential to fully elucidate the in vivo fates of ACT immune cells and promote the development of ACT. Significant advances have been made in the application of ACT in the treatment of hematological tumors, but the application of such immunotherapy in the treatment of solid tumors remains in its early stage [61,62]. This provides an excellent opportunity to develop optical imaging probes to promote the development of ACT.…”

Section: Challenges For the Application Of Optical Imaging To In Vivo...mentioning

confidence: 99%

Optical imaging of in vivo adoptive T‐cell therapy: State of the art and challenges

Gao

et al. 2023

iRADIOLOGY

View full text Add to dashboard Cite

Adoptive T‐cell therapy (ACT), which is an important type of live cell therapy, has achieved unprecedented success in treating hematological malignancies. Recent studies have shown that ACT is also a promising treatment for solid tumors. Visualizing the in vivo fates (distribution, homing, infiltration, proliferation, and exhaustion) of the immune cells used for ACT (ACT immune cells) is of great importance to promote basic research and clinical translation of ACT. Optical imaging techniques, including bioluminescence, fluorescence, and photoacoustic imaging, have the advantages of high sensitivity, high spatiotemporal resolution, minimal exposure to harmful radiation, and simple instrumentation. Recently, various types of optical imaging probes, including bioluminescence, fluorescence, and photoacoustic imaging probes, have been used to visualize ACT immune cells in vivo and evaluate the molecular mechanism, efficacy, and side effects of ACT. In this review, the optical imaging probes and labeling methods that have been used for in vivo visualization of ACT immune cells are summarized, and the opportunities and challenges of using optical imaging to visualize ACT immune cells in vivo are discussed.

show abstract

“…The accumulation of lipid per-oxides also alters the viscosity of LDs, and various fluorophores have been utilized to visualize this viscosity-dependent process. [8][9][10][11][12] The design strategy often involves a donor-π-acceptor architecture, which results in polarity-dependent solvatochromic emission. The presence of rotatable bonds further enhances the emission in higher viscosity media, owing to the restricted rotation and reduced non-radiative processes, making them ideal for investigating multiple targeted cellular processes.…”

Section: Introductionmentioning

confidence: 99%

Improved lipophilic probe for visualizing lipid droplets in erastin-induced ferroptosis

Rajput,

Mahalingavelar,

Soppina

et al. 2023

Org. Biomol. Chem.

View full text Add to dashboard Cite

show abstract

Fluorescent probes for ferroptosis bioimaging: advances, challenges, and prospects

Abstract: Ferroptosis is a form of regulatory cell death distinct from caspase-dependent apoptosis and visualization of its process based on fluorescence imaging technology is important for life entities.

Cited by 66 publications

References 105 publications

Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer

Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer

Optical imaging of in vivo adoptive T‐cell therapy: State of the art and challenges

Improved lipophilic probe for visualizing lipid droplets in erastin-induced ferroptosis

Contact Info

Product

Resources

About