Fluorescent phenylthiazoles: Application as latent fingermark and their cytotoxicity against NOK-SI cell line

Rosa, Bruno Nunes da; Mariotti, Kristiane de Cássia; Pacheco, Bruna Silveira; Silva, Caroline Carapina da; Carreño, Neftalí Lênin Villarreal; Nicolodi, Caroline; Poletti, Tais; Silva, Allison Carlos Assunção; Silva, Adriana Fernandes da; Giongo, Janice Luehring; Vaucher, Rodrigo de Almeida; Oliveira, Tiago Franco de; Pereira, Cláudio M. P.

doi:10.1016/j.cdc.2021.100700

Cited by 3 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Miscellaneous. da Rosa et al 80 developed an effective methodology for the synthesis of 2-(3,5-diaryl-4,5-dihydro-1Hpyrazol-1-yl)-4-phenylthiazoles 57a−57d, achieving a moderate yield. The synthetic methodology employed herein entailed the reaction between 1-thiocarbamoyl-4,5-dihydro-1H-pyrazoles 56 and phenacyl halide 40 in an ethanol medium, utilizing reflux conditions implemented on a water bath over a period of 4 h. The resultant hybrid compounds were subjected to comprehensive evaluation for both cytotoxicity and utility as latent fingermark (LFM) agents.…”

Section: Morpholine-linked Hybridsmentioning

confidence: 99%

Development in the Synthesis of Bioactive Thiazole-Based Heterocyclic Hybrids Utilizing Phenacyl Bromide

Kumari,

Dhillon,

Rani

et al. 2024

ACS Omega

View full text Add to dashboard Cite

Heterocyclic hybrid frameworks represent a burgeoning domain within the realms of drug discovery and medicinal chemistry, attracting considerable attention in recent years. Thiazole pharmacophore fragments, inherent in natural products such as peptide alkaloids, metabolites, and cyclopeptides, have demonstrated a broad spectrum of pharmacological potentials. Given their profound biological significance, a plethora of thiazole-based hybrids have been synthesized through the conjugation of thiazole moieties with bioactive pyrazole and pyrazoline fragments. This review systematically presents a compendium of robust methodologies for the synthesis of thiazole-linked hybrids, employing the (3 + 2) heterocyclization reaction, specifically the Hantzsch-thiazole synthesis, utilizing phenacyl bromide as the substrate. The strategic approach of molecular hybridization has markedly enhanced drug efficacy, mitigated resistance to multiple drugs, and minimized toxicity concerns. The resultant thiazole-linked hybrids exhibit a myriad of medicinal properties viz. anticancer, antibacterial, anticonvulsant, antifungal, antiviral, and antioxidant activities. This compilation of methodologies and insights serves as a valuable resource for medicinal chemists and researchers engaged in the design of novel thiazole-linked hybrids endowed with therapeutic attribute.

show abstract

Section: Morpholine-linked Hybridsmentioning

confidence: 99%

Development in the Synthesis of Bioactive Thiazole-Based Heterocyclic Hybrids Utilizing Phenacyl Bromide

Kumari,

Dhillon,

Rani

et al. 2024

ACS Omega

View full text Add to dashboard Cite

show abstract

“…Preliminary/Pilot studies – Several compounds were presented as new dusting powders: AIE-active composites or molecules [ [277] , [278] , [279] , [280] , [281] ], algal biomass [ 282 ], anti-perovskite phosphors [ 283 ], azo-dyes [ 284 ], β-cyclodextrin-berberine complexes [ 285 ], benzazole derivatives [ 286 ], bisamide analogues [ 287 ], cadmium-doped silica microspheres [ 288 ], chitosan-tripolyphosphate-lysine conjugates [ 289 ], coumarin–pyridone conjugates [ 290 ], crushed eggshells and clamshells [ 291 ], crushed gambir [ 292 ], curcumin analogues [ 293 ], doped montmorillonite [ 278 , 294 , 295 ], doped starch microspheres [ [296] , [297] , [298] ], europium-dextrose composites [ 299 ], iron oxide/zinc sulphide hybrid [ 300 ], metal-organic frameworks [ 301 ], organic NIR emitters [ 302 , 303 ], perylenetetracarboxylate compounds [ 304 ], phenylthiazoles [ 305 ], phosphor-cellulose hybrids [ 306 ], pyrazoles [ 307 ], pyrene-tagged imidazolium salts [ 308 ], pyridine and pyrimidine derivatives [ 309 , 310 ], rare-earth-doped phosphors [ [311] , [312] , [313] , [314] , [315] , [316] , [317] , [318] , [319] ], reduced graphene oxides [ 320 ], resveratrol powder [ 321 ], rhodamine B-doped diatomaceous earth [ 322 ], Schiff base complexes [ [323] , [324] , [325] ], talcum powder […”

Section: Fingermark Visualisationmentioning

confidence: 99%