Fluorescent pH nanosensors: Design strategies and applications

Shamsipur, Mojtaba; Barati, Ali; Nematifar, Ziba

doi:10.1016/j.jphotochemrev.2019.03.001

Cited by 90 publications

(48 citation statements)

References 472 publications

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“…Transparent, non-toxic and hydrophilic silica nanoparticles (SNs) are of greater impact on sensing and imaging among other polymeric nanoparticles [ 85 , 86 ]. However, conditions of alkaline- or acid-catalyzed hydrolysis of tetraethoxysilane are unfavorable for safe doping of 1,3-diketonate lanthanide complexes into silica matrix due to hydrolysis of lanthanide ions [ 28 , 81 ].…”

Section: Nanoparticulate Forms Of Cyclophanic 13-diketonate Complmentioning

confidence: 99%

1,3-Diketone Calix[4]arene Derivatives—A New Type of Versatile Ligands for Metal Complexes and Nanoparticles

2021

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The present review is aimed at highlighting outlooks for cyclophanic 1,3-diketones as a new type of versatile ligands and building blocks of the nanomaterial for sensing and bioimaging. Thus, the main synthetic routes for achieving the structural diversity of cyclophanic 1,3-diketones are discussed. The structural diversity is demonstrated by variation of both cyclophanic backbones (calix[4]arene, calix[4]resorcinarene and thiacalix[4]arene) and embedding of different substituents onto lower or upper macrocyclic rims. The structural features of the cyclophanic 1,3-diketones are correlated with their ability to form lanthanide complexes exhibiting both lanthanide-centered luminescence and magnetic relaxivity parameters convenient for contrast effect in magnetic resonance imaging (MRI). The revealed structure–property relationships and the applicability of facile one-pot transformation of the complexes to hydrophilic nanoparticles demonstrates the advantages of 1,3-diketone calix[4]arene ligands and their complexes in developing of nanomaterials for sensing and bioimaging.

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Section: Nanoparticulate Forms Of Cyclophanic 13-diketonate Complmentioning

confidence: 99%

1,3-Diketone Calix[4]arene Derivatives—A New Type of Versatile Ligands for Metal Complexes and Nanoparticles

2021

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“…A topical review on fluorescent probes and nanoparticles for use in intracellular sensing of pH values has been presented in 2014 by Shi et al, 4 and another one was published in 2019 by the Wang group. 5 A most informative review was presented by Shamsipur et al 6 on fluorometric nanosensors for pH values. While limited to fluorometry and nanoparticles (NPs), it gives a complete account on the various kinds of NPs that have been used in the past, from quantum dots, nanoclusters, carbonaceous dots, upconversion NPs, frameworks, metal, silica and polymer NPs to proteinic NPs.…”

Section: Introduction Definition Of the Ph Value And General Considmentioning

confidence: 99%

Optical Sensing and Imaging of pH Values: Spectroscopies, Materials, and Applications

2020

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This is the first comprehensive review on methods and materials for use in optical sensing of pH values and on applications of such sensors. The Review starts with an introduction that contains subsections on the definition of the pH value, a brief look back on optical methods for sensing of pH, on the effects of ionic strength on pH values and p K a values, on the selectivity, sensitivity, precision, dynamic ranges, and temperature dependence of such sensors. Commonly used optical sensing schemes are covered in a next main chapter, with subsections on methods based on absorptiometry, reflectometry, luminescence, refractive index, surface plasmon resonance, photonic crystals, turbidity, mechanical displacement, interferometry, and solvatochromism. This is followed by sections on absorptiometric and luminescent molecular probes for use pH in sensors. Further large sections cover polymeric hosts and supports, and methods for immobilization of indicator dyes. Further and more specific sections summarize the state of the art in materials with dual functionality (indicator and host), nanomaterials, sensors based on upconversion and 2-photon absorption, multiparameter sensors, imaging, and sensors for extreme pH values. A chapter on the many sensing formats has subsections on planar, fiber optic, evanescent wave, refractive index, surface plasmon resonance and holography based sensor designs, and on distributed sensing. Another section summarizes selected applications in areas, such as medicine, biology, oceanography, bioprocess monitoring, corrosion studies, on the use of pH sensors as transducers in biosensors and chemical sensors, and their integration into flow-injection analyzers, microfluidic devices, and lab-on-a-chip systems. An extra section is devoted to current challenges, with subsections on challenges of general nature and those of specific nature. A concluding section gives an outlook on potential future trends and perspectives.

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“…Examples of MOFs were applied to intracellular pH ratiometric measurement. M. Shamsipur and coworkers provide a review of the current strategies used to develop nanosized systems (up to 2019) for fluorescence pH sensing [ 82 ]. Following with this review, we provide a chemical overview of the most significant recent examples of nanosized and MOFs pH VSs.…”

Section: Nano-sized Visual Ph Sensorsmentioning

confidence: 99%

Visual pH Sensors: From a Chemical Perspective to New Bioengineered Materials

Costanzo

Panunzi

2021

Molecules

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Many human activities and cellular functions depend upon precise pH values, and pH monitoring is considered a fundamental task. Colorimetric and fluorescence sensors for pH measurements are chemical and biochemical tools able to sense protons and produce a visible signal. These pH sensors are gaining widespread attention as non-destructive tools, visible to the human eye, that are capable of a real-time and in-situ response. Optical “visual” sensors are expanding researchers’ interests in many chemical contexts and are routinely used for biological, environmental, and medical applications. In this review we provide an overview of trending colorimetric, fluorescent, or dual-mode responsive visual pH sensors. These sensors include molecular synthetic organic sensors, metal organic frameworks (MOF), engineered sensing nanomaterials, and bioengineered sensors. We review different typological chemical entities of visual pH sensors, three-dimensional structures, and signaling mechanisms for pH sensing and applications; developed in the past five years. The progression of this review from simple organic molecules to biological macromolecules seeks to benefit beginners and scientists embarking on a project of pH sensing development, who needs background information and a quick update on advances in the field. Lessons learned from these tools will aid pH determination projects and provide new ways of thinking for cell bioimaging or other cutting-edge in vivo applications.

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Fluorescent pH nanosensors: Design strategies and applications

Cited by 90 publications

References 472 publications

1,3-Diketone Calix[4]arene Derivatives—A New Type of Versatile Ligands for Metal Complexes and Nanoparticles

1,3-Diketone Calix[4]arene Derivatives—A New Type of Versatile Ligands for Metal Complexes and Nanoparticles

Optical Sensing and Imaging of pH Values: Spectroscopies, Materials, and Applications

Visual pH Sensors: From a Chemical Perspective to New Bioengineered Materials

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