Fluorescent paper–based sensor based on carbon dots for detection of folic acid

Li, Wang; Zhang, Xiaoyue; Miao, Chunyue; Li, Ruijun; Ji, Yibing

doi:10.1007/s00216-020-02507-w

Cited by 69 publications

(27 citation statements)

References 45 publications

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“…As shown in Figure c, no significant alteration was noticed in the luminescence intensity of M-CDs in the presence of these afore-mentioned biomolecules, validating the high selectivity of the system toward folic acid (FA). Although there are several other fluorescent sensors for the detection of FA, none of them detail the exact specificity of the system over other biological analytes. − To deeply probe this matter, the UV absorption spectral behavior of the system toward FA was analyzed. As noted from Figure a, a small increase in the absorbance value of M-CDs was observed at 278 nm by the introduction of FA, indicating a special affinity of M-CDs toward FA.…”

Section: Resultsmentioning

confidence: 99%

“…Li et al have reported the synthesis of fluorescent carbon dots (CDs) for assaying FA by using citric acid and the ethylene imine polymer as precursors. 42 Aconitic acid and lactose were also utilized in this direction. 41 , 43 AgInS 2 quantum dots were developed by another group for the detection of FA.…”

Section: Introductionmentioning

confidence: 99%

“…FA plays a crucial role in the formation of red blood cells, body growth, and prevention of anemia. − As a significant biomolecule, the deficiency of FA leads to a number of chronic diseases including stroke, heart attack, psychosis, mentality devolution, neural tube disorder, and so forth, and a high dose may cause pernicious anemia. , Carbon dots derived from chemical precursors are explored by some researchers to trace this analyte. Li et al have reported the synthesis of fluorescent carbon dots (CDs) for assaying FA by using citric acid and the ethylene imine polymer as precursors . Aconitic acid and lactose were also utilized in this direction. , AgInS 2 quantum dots were developed by another group for the detection of FA .…”

Section: Introductionmentioning

confidence: 99%

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Fluorescent Carbon Dots as Biosensor, Green Reductant, and Biomarker

Raveendran

Renuka

2021

ACS Omega

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Carbon dots, the celebrated green material among the nanocarbon family, are blessed with several interesting features like biocompatibility, solubility, tunable luminescence, and so forth. Herein, carbon dots derived from Mint leaf extract (M-CDs) via a green method are exploited for versatile applications as a biosensor, reductant, and biomarker. M-CDs are applied for fluorimetric sensing of biologically relevant folic acid through quenching response originating from the inner filter effect, with a limit of detection of 280 nM. The carbon dots were highly selective toward folic acid in a collection of 16 biomolecules. The specificity of carbon dots toward folic acid is explained based on the interaction between the two. Along with sensing, herein, we project M-CDs as a green reducing agent by demonstrating the reduction of Fe(III) and noble metal nanoparticle synthesis from their salt solutions. The particles are found to be significantly non-cytotoxic, as evident from the MTT assay performed on primary H8 cells. The application of M-CDs in multicolor imaging is also illustrated using HeLa cells.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fluorescent Carbon Dots as Biosensor, Green Reductant, and Biomarker

Raveendran

Renuka

2021

ACS Omega

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“…This paper-based plasmonic alloy substrate enables a two-fold increase in fluorescence signals and selective MEF signals, compared to Whatman chromatography paper. The proposed sensing device allows detection of folic acid at a picomolar level (LOD 1 pM), which is 1000 times more sensitive than other carbon dot-based paper devices (0.28 µmol/L) [ 89 ]. Paper-based devices have also been fabricated for the detection of foodborne bacteria.…”

Section: Surface-enhanced Raman Scattering Signal Amplificationmentioning

confidence: 99%

Advanced Signal-Amplification Strategies for Paper-Based Analytical Devices: A Comprehensive Review

Hoang

Phan

et al. 2021

Biomedicines

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Paper-based analytical devices (PADs) have emerged as a promising approach to point-of-care (POC) detection applications in biomedical and clinical diagnosis owing to their advantages, including cost-effectiveness, ease of use, and rapid responses as well as for being equipment-free, disposable, and user-friendly. However, the overall sensitivity of PADs still remains weak, posing a challenge for biosensing scientists exploiting them in clinical applications. This review comprehensively summarizes the current applicable potential of PADs, focusing on total signal-amplification strategies that have been applied widely in PADs involving colorimetry, luminescence, surface-enhanced Raman scattering, photoacoustic, photothermal, and photoelectrochemical methods as well as nucleic acid-mediated PAD modifications. The advances in signal-amplification strategies in terms of signal-enhancing principles, sensitivity, and time reactions are discussed in detail to provide an overview of these approaches to using PADs in biosensing applications. Furthermore, a comparison of these methods summarizes the potential for scientists to develop superior PADs. This review serves as a useful inside look at the current progress and prospective directions in using PADs for clinical diagnostics and provides a better source of reference for further investigations, as well as innovations, in the POC diagnostics field.

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“…无机化学实验是化学及相关专业学生的必修课程。传统的无机化学实验以验证和制备实验为主，内容较为陈旧，与当今科技的迅速发展不相匹配。故我校近两年正着手推进无机化学实验课程的改革，即以科学性为基础，将涉及科技前沿的材料纳入实验教学中，增强学生实验技能的同时，加强实验的趣味性、实用性和时代感，让学生在实验过程中增强专业技能，了解科技前沿，全身心地融入到实验中。多色荧光碳量子点作为近几年新兴的荧光材料，具有绿色环保、发光性能好、制备简单易操作等特点，现有的荧光碳点制备方法主要分为两大类，即以电解、刻蚀石墨烯等大分子的"自上而下" 法和以有机小分子为前驱体的"自下而上"法，其中应用较多的为"自下而上"法，如基于碳点的发光特性将其应用于生物体系的检测和成像 [1] ，或是荧光防伪 [2] 。"荧光碳点的制备及其荧光特性" 综合实验的开设，可以帮助学生理解光致发光理论，掌握电热恒温干燥箱、真空干燥箱、紫外可见分光光度计、荧光分光光度计以及origin数据软件的使用方法，实验最后设计了荧光碳点应用于防伪墨水这一项内容，鼓励学生学以致用，强化在科研实践中根据材料特点设计运用到各种不同生产实践场景的意识，从而培养学生的自主创新意识和专业报国情怀。荧光碳点的制备及荧光特性表征实验已在我校2018和2019级化学、宗濂等专业学生中开设，受到学生的一致好评。…”

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