Fluorescent organic nanoparticles (FONs) as convenient probes for metal ion detection in aqueous medium

Ahmed, Mukhtiar; Faisal, Muhammad; Ihsan, Ayesha; Naseer, Muhammad Moazzam

doi:10.1039/c8an01801d

Cited by 57 publications

(25 citation statements)

References 105 publications

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“…Similar observations have been seen in fluorescence organic nanoparticlebased chemosensors. [49] Secondly, quenching by dynamic mechanisms was verified using the linear SV equation Eqn 2given by:…”

Section: Mechanism Of the Fluorophore-quencher Interactionmentioning

confidence: 99%

Biologically synthesized ZnS quantum dots as fluorescent probes for lead (II) sensing

2020

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This manuscript presents a robust strategy for selective Pb(II) sensing based on a fluorescence turn‐off mechanism using ZnS quantum dots (QDs) biosynthesized using Aspergillus sp. The biogenic nanoprobe displayed marked sensing efficiency in the presence of Pb ions over concentration ranges from 5 to 100 μM with limits of detection of around 2.45 μM. Performance optimization studies revealed that the maximum fluorescence quenching efficiency was obtained in the presence of [ZnS NPs] at 4 mg/ml, and alkaline pH of 10 recorded under stable ambient temperature for approximately 5 min for the quenching process. Advanced morphological analysis indicated that the bio‐sensing mechanism was essentially a surface‐based phenomenon in which the Pb ions were in very close proximity to the QDs and formed stable ground‐state Pb–ZnS complexes, resulting in a quenched fluorescence of the QDs. Simultaneously, a larger fraction of Pb ions interacted via collisions with the excited ZnS QDs and resulted in an effective energy transfer from the excited QDs to the Pb ions, therefore resulting in an obvious decrease in QD fluorescence. These insights were well supported by theoretical analysis using Stern–Volmer plots and sphere‐of‐action models.

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Section: Mechanism Of the Fluorophore-quencher Interactionmentioning

confidence: 99%

Biologically synthesized ZnS quantum dots as fluorescent probes for lead (II) sensing

2020

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“…As a continuation of our recent interests in supramolecular chemistry [24][25][26][27][28][29], herein we report a simple artificial colored receptor based on the well-known color dye isatin. The proposed receptor owns two different types of NH-hydrogen bond donors (NH-isatin and NH-thiourea-).…”

Section: Introductionmentioning

confidence: 97%

Isatin-3-thiosemicarbazone as Chromogenic Sensor for the Selective Detection of Fluoride Anion

Rasheed

Ahmed

Faisal

et al. 2020

Heterocyclic Communications

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In this study, we describe the anion recognition ability of isatin-3-thiosemicarbazone 2, which contains two different anion recognition units i.e. isatin NH and the thiourea moiety. Both have the ability to act as proton donors. Most importantly, a significant colour change of 2 was observed (from light yellow to reddish orange) in organic medium only after the addition of the F– anion. No such colour change could be observed for any other anions including Cl–, Br–, I–, ${{\text{H}}_{2}}\text{P}{{\text{O}}_{4}}^{-},$$\text{N}{{\text{O}}_{\text{2}}}^{-},$$\text{P}{{\text{F}}_{4}}^{-}$etc. The UV-Vis spectroscopic studies also indicate the potential of this compound for selective detection of fluoride anions. 1H-NMR titrations clearly indicate the formation of the 2.F– anionic complex. The Density-functional theory (DFT) calculations are also performed to get further insights on the formation of 2.F– complex.

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“…To improve the performance of these sensors, it is necessary to develop fluorescent probes that exhibit a spectral response upon binding to ions and neutral organic or inorganic molecules. This will enable the measurement of changes in free guest ions or changes in the concentration of bio- and environmental molecules with high sensitivity and selectivity [ 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. This approach generally has a high throughput and represents a highly sensitive and selective method for the analysis of target molecules.…”

Section: Introductionmentioning

confidence: 99%

Development of Magnetic Nanobeads Modified by Artificial Fluorescent Peptides for the Highly Sensitive and Selective Analysis of Oxytocin

Suzuki

2020

Sensors

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We describe two novel fluorescent peptides (compounds 1 and 2) targeting oxytocin with a boron-dipyrromethenyl group as the fluorophore bound to an artificial peptide based on the oxytocin receptor, and their application for the analysis of oxytocin levels in human serum using nanometer-sized magnetic beads modified by fluorescent peptides (FMB-1 and FMB-2). Under the optimized experimental protocols, FMB-1 and FMB-2 emitted low levels of fluorescence but emitted much higher levels of fluorescence when associated with oxytocin. The detection limit of oxytocin by FMB-2 was 0.4 pM, which is approximately 37.5 times higher than that of conventional methods, such as ELISA. Using these fluorescent sensors, oxytocin was specifically detected over a wide linear range with high sensitivity, good reusability, stability, precision, and reproducibility. This fluorescent sensor-based detection system thus enabled the measurement of oxytocin levels in human serum, which has widespread applications for oxytocin assays across varied research fields.

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Fluorescent organic nanoparticles (FONs) as convenient probes for metal ion detection in aqueous medium

Abstract: Fluorescent organic nanoparticle (FON)-based chemosensors are emerging as a valuable tool for the fast and accurate detection of metal ions in aqueous media. In this review, we highlight the recent developments in this field.

Cited by 57 publications

References 105 publications

Biologically synthesized ZnS quantum dots as fluorescent probes for lead (II) sensing

Biologically synthesized ZnS quantum dots as fluorescent probes for lead (II) sensing

Isatin-3-thiosemicarbazone as Chromogenic Sensor for the Selective Detection of Fluoride Anion

Development of Magnetic Nanobeads Modified by Artificial Fluorescent Peptides for the Highly Sensitive and Selective Analysis of Oxytocin

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