Fluorescent Nanorods and Nanospheres for Real‐Time In Vivo Probing of Nanoparticle Shape‐Dependent Tumor Penetration

Chauhan, Vikash P.; Popović, Zoran V.; Chen, Ou; Cui, Jian; Fukumura, Dai; Bawendi, Moungi G.; Jain, Rakesh K.

doi:10.1002/anie.201104449

Cited by 400 publications

(324 citation statements)

References 32 publications

(35 reference statements)

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“…luijten@northwestern.edu biofunctionality, including cellular and tissue uptake, 17,18 tissue diffusion, 19 and circulation stability. 20 In collaboration with Mao and co-workers, we previously reported effective shape control of plasmid DNA and polyphosphoramidate (PPA)-based nanoparticles 21,22 and showed that nanoparticle shape correlates with transfection efficiency.…”

Section: Introductionmentioning

confidence: 99%

Systematic coarse-grained modeling of complexation between small interfering RNA and polycations

Wei

Luijten

2015

The Journal of Chemical Physics

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All-atom molecular dynamics simulations can provide insight into the properties of polymeric gene-delivery carriers by elucidating their interactions and detailed binding patterns with nucleic acids. However, to explore nanoparticle formation through complexation of these polymers and nucleic acids and study their behavior at experimentally relevant time and length scales, a reliable coarse-grained model is needed. Here, we systematically develop such a model for the complexation of small interfering RNA (siRNA) and grafted polyethyleneimine copolymers, a promising candidate for siRNA delivery. We compare the predictions of this model with all-atom simulations and demonstrate that it is capable of reproducing detailed binding patterns, charge characteristics, and water release kinetics. Since the coarse-grained model accelerates the simulations by one to two orders of magnitude, it will make it possible to quantitatively investigate nanoparticle formation involving multiple siRNA molecules and cationic copolymers. C 2015 AIP Publishing LLC. [http://dx

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Section: Introductionmentioning

confidence: 99%

Systematic coarse-grained modeling of complexation between small interfering RNA and polycations

Wei

Luijten

2015

The Journal of Chemical Physics

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“…They found that the PEGylation of NPs could improve the transport of these NPs through the mucus barrier. In addition to these studies that focused on the surface chemistry of NPs, it has also been recognized that shape may affect the diffusion of particles in porous media [20][21][22] and cellular uptake of NPs [23][24][25][26][27] . For example, Geng et al demonstrated that filomicelles have much 4 longer circulation time than spherical counterparts 28 .…”

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confidence: 99%

Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues

et al. 2016

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Mucus is a viscoelastic gel layer that typically protects exposed surfaces of the gastrointestinal (GI) tract, lung airways, and other mucosal tissues. Particles targeted to these tissues can be efficiently trapped and removed by mucus, thereby limiting the effectiveness of such drug delivery systems. In this study, we experimentally and theoretically demonstrated that cylindrical nanoparticles (NPs), such as mesoporous silica nanorods and calcium phosphate nanorods, have superior transport and trafficking capability in mucus compared with spheres of the same chemistry. The higher diffusivity of nanorods leads to deeper mucus penetration and a longer retention time in the GI tract than that of their spherical counterparts. Molecular simulations and stimulated emission of depletion (STED) microscopy revealed that this anomalous phenomenon can be attributed to the rotational dynamics of the NPs facilitated by the mucin fibers and the shear flow. These findings shed new light on the shape design of NP-based drug delivery systems targeted to mucosal and tumor sites that possess a fibrous structure/porous medium.

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“…Nanoparticulates possess the ability to be either passively targeted to tumour vasculature through the enhanced permeability and retention effect [11] or actively targeted to specific sites after functionalisation with specific ligands [12]. Previous studies have shown that after coupling cytotoxics onto nanoparticles, this increased tumour penetration and resulted in more effective therapies [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Thermally triggered theranostics for pancreatic cancer therapy

et al. 2017

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Hybrid iron oxide-gold nanoparticles (HNPs) are capable of drug binding onto their surface with a triggered release at elevated temperatures. The iron oxide core allows for diagnostic imaging whilst heating of the gold shell upon laser irradiation reverses drug binding. This study exploits the reversible binding of novel polyamine based drugs in order to provide specific and effective method for pancreatic cancer treatment. Here we used novel bisnaphthalamido (BNIP) based drug series. Our hybrid nanoparticles (50 nm) were capable of drug loading onto their surface (3:1:0.25, Drug:Fe:Au). By exploiting the surface-to-drug electrostatic interaction of a range of BNIP agents, heat triggered drug release was achieved.12-fold reduction in IC 50 after 24 h in vitro and 5-fold reduction of tumour retardation in vivo compared with free drug in pancreatic models after treatment with the HNP-formulation and laser irradiation. This heat activated system could provide a key platform for future therapy strategies.

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Fluorescent Nanorods and Nanospheres for Real‐Time In Vivo Probing of Nanoparticle Shape‐Dependent Tumor Penetration

Cited by 400 publications

References 32 publications

Systematic coarse-grained modeling of complexation between small interfering RNA and polycations

Systematic coarse-grained modeling of complexation between small interfering RNA and polycations

Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues

Thermally triggered theranostics for pancreatic cancer therapy

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