Fluorescent nano‐particles prepared by eATRP combined with self‐assembly imprinting technology

Abstract

A novel amphiphilic photoreactive block copolymer was synthesized by electrochemically mediated atom transfer radical polymerization (eATRP) of glycidyl methacrylate (GMA), N‐vinyl carbazole (VK) with polyethylene glycol‐based initiator (PEG‐Br). And then the double bond and the boric acid group were introduced through the epoxy group. Fluorescent molecularly imprinted nanoparticles (nano‐FMIPs) were prepared using self‐assembly imprinting technology with PEG‐b‐P(GMA‐co‐VK) as a functional monomer and sialic acid (SA) as a template molecule. The nano‐FMIPs prepared by this method have the advantages of uniform size and small particle size, which greatly improves their recognition performance. It is found that the SA template can significantly quench the fluorescence intensity of nano‐FMIPs linearly within a concentration range of 4 × 10−4–4 × 10−6 mol L−1, which is well described by Stern–Volmer equation. The nano‐FMIPs can selectively and sensitively detect down to 2.9 μM of SA concentration. This study provides a new and general strategy for the preparation of nano‐MIPs with high selective recognition ability in aqueous media, which has good application prospects in biomedicine.

Functional Lignin‐based Polymers: Isolation, Synthetic Methods and High‐valued Applications

“…It can control the graft density by controlling the initial active site density of lignin macromolecular initiator, and control the grafted polymer length. [85] CRP mainly included atom transfer radical polymerization (ATRP) and reversible addition fragmentation chain transfer polymerization (RAFT).…”

Electrochemically Mediated Surface-Initiated Atom Transfer Radical Polymerization by ppm of CuII/Tris(2-pyridylmethyl)amine

“…Significant progress has been witnessed in the electrochemically mediated surface-initiated ATRP (SI-eATRP) method. Matyjaszewski reported the first example of eATRP, and after that, eATRP has been widely used to prepare well-controlled polymers both in solution and on the surface. ,− Unlike a conventional ATRP reaction in a solution, in surface-initiated polymerization, the reaction occurs only on the surface, and the polymerization kinetics is typically controlled by the local Cu I /Cu II concentration at the vicinity of the surface on which the initiator is tethered rather than the concentration of Cu I /Cu II in the bulk solution . In a typical process of SI-eATRP, Cu I activators form at the working electrode upon application of a reduction potential of Cu II to Cu I , and eATRP is initiated when the Cu I catalyst diffuses to the substrate modified by the initiator. , Notably, Cu I is dynamically generated throughout the polymerization process, and controlling the Cu I /Cu II concentration is limited by the detection capability of the electrochemical workstation.…”