Fluorescent labeling of a narrow polydispersity high molecular weight polystyrene

Porouchani, Réza; Garamszegi, László Zsolt; Nguyen, Tuan Q.; Hilborn, Jöns

doi:10.1002/1521-3927(20000801)21:12<837::aid-marc837>3.0.co;2-e

Cited by 4 publications

(5 citation statements)

References 2 publications

(3 reference statements)

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“…[6,7] Nevertheless, when the chain coupling is carried out under static conditions at the interface between pre-cast films, the extent of the reaction and the amount of copolymer formed are so limited that the analysis remains a problem. [8] Recently, Nguyen et al [9] and Macosko et al [10] reported on the anionic synthesis of polystyrene (PS) labeled with one or several anthracene group(s), and of poly(methyl Full Paper: Anthracene-labeled polystyrene (PS) endcapped by a primary amine has been synthesized by atom transfer radical copolymerization of styrene with 3-isopropenyl-a,a-dimethylbenzyl isocyanate (m-TMI). The m-TMI co-monomer (5.7 mol-%) does not perturb the control of the radical polymerization of styrene.…”

Section: Introductionsupporting

confidence: 75%

Controlled synthesis of anthracene-labeled -amine polystyrene to be used as a probe for interfacial reaction with mutually reactive PMMA

Yin¹,

Koulic²,

Pagnoulle³

et al. 2002

Macromol. Chem. Phys.

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Section: Introductionsupporting

confidence: 75%

Controlled synthesis of anthracene-labeled -amine polystyrene to be used as a probe for interfacial reaction with mutually reactive PMMA

Yin¹,

Koulic²,

Pagnoulle³

et al. 2002

Macromol. Chem. Phys.

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“…In contrast, chromatographic methods have the capacity to tackle this analytical problem, provided that the detector is very responsive to the chains, which is the case for chains tagged with UV absorbing groups and analyzed by SEC with a UV detector (SEC-UV). Anthracene is known for sensitivity to UV and fluorescence detection. , A previous study has shown that the extent of the copolymer formation at the interface of thin films of PS-NH 2 (670 nm thick) and PMMA-anh (250 nm thick) coated on a 1.2 × 1.4 cm 2 silicon wafer could be quantified as a result of the anthracene labeling of the PS-NH 2 chains . The same technique was used in this work.…”

Section: Resultsmentioning

confidence: 99%

Probing of the Reaction Progress at a PMMA/PS Interface by Using Anthracene-Labeled Reactive PS Chains

et al. 2002

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The progress of the interfacial reaction of polystyrene chains end-capped by a primary amine (PS-NH2) and PMMA chains end-capped by an anhydride (PMMA-anh) has been monitored by SEC-UV, by using anthracene-labeled polystyrene chains (anth-PS-NH 2) as a probe. Assemblies of an anth-PS-NH2 layer and a PMMA-anh layer were annealed at 200 °C for various periods of time. The interfacial reaction rate depends on the molecular weight (MW) of the reactive precursors in relation to the χN value of the chains. For chains of low χN (χN ) 6), the reaction is faster because the interface becomes more diffuse with time, as observed by TEM and AFM, consistent with compatibilization of the weakly immiscible polymers by the copolymer formed in-situ. For chains of higher molecular weight and χN (10, instead of 6), the interface is much sharper and the residence time at the interface of the symmetric diblock copolymer of higher molecular weight is also increased, which dramatically restricts the progress of the interfacial reaction under the annealing conditions used in this work.

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“…Recently, Nguyen et al9 and Macosko et al10 reported on the anionic synthesis of polystyrene (PS) labeled with one or several anthracene group(s), and of poly(methyl methacrylate) (PMMA) bearing one anthracene label. These chains were well suited to analysis by SEC equipped with UV and fluorescence detectors.…”

Section: Introductionmentioning

confidence: 99%

(R)‐α‐Lipoyl‐Glycyl‐L‐Prolyl‐L‐Glutamyl Dimethyl Ester Codrug as a Multifunctional Agent with Potential Neuroprotective Activities

et al. 2012

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The (R)-α-lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug (LA-GPE, 1) was synthesized as a new multifunctional drug candidate with antioxidant and neuroprotective properties for the treatment of neurodegenerative diseases. Physicochemical properties, chemical and enzymatic stabilities were evaluated, along with the capacity of LA-GPE to penetrate the blood-brain barrier (BBB) according to an in vitro parallel artificial membrane permeability assay for the BBB. We also investigated the potential effectiveness of LA-GPE against the cytotoxicity induced by 6-hydroxydopamine (6-OHDA) and H2O2 on the human neuroblastoma cell line SH-SY5Y by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction assay. Our results show that codrug 1 is stable at both pH 1.3 and 7.4, exhibits good lipophilicity (log P=1.51) and a pH-dependent permeability profile. Furthermore, LA-GPE was demonstrated to be significantly neuroprotective and to act as an antioxidant against H2O2- and 6-OHDA-induced neurotoxicity in SH-SY5Y cells.

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Fluorescent labeling of a narrow polydispersity high molecular weight polystyrene

Cited by 4 publications

References 2 publications

Controlled synthesis of anthracene-labeled -amine polystyrene to be used as a probe for interfacial reaction with mutually reactive PMMA

Controlled synthesis of anthracene-labeled -amine polystyrene to be used as a probe for interfacial reaction with mutually reactive PMMA

Probing of the Reaction Progress at a PMMA/PS Interface by Using Anthracene-Labeled Reactive PS Chains

(R)‐α‐Lipoyl‐Glycyl‐L‐Prolyl‐L‐Glutamyl Dimethyl Ester Codrug as a Multifunctional Agent with Potential Neuroprotective Activities

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