Fluorescent di-(2-picolyl)amine based drug-like ligands and their Re(CO)3 complexes towards biological applications

Synthesis, characterization and biological evaluation of dipicolylamine sulfonamide derivatized platinum complexes as potential anticancer agents

“…A solution of 1-naphthalene sulfonyl chloride (2.5 mmol, 0.572 g) was added to a solution of N(H)dpa (5 mmol, 0.92 ml) according to a known procedure to obtain N(SO 2 (2-nap))dpa ligand as a brown coloured oil (0.681 g, 70%). 43 1 H NMR, UV-vis and FTIR data matched with previously reported data.…”

“…This is qualitatively in agreement with the experimental spectrum and previous studies. 43 In the case of [PtCl 2 (N(SO 2 (2-nap))dpa)] complex, NTOs indicated that the key excitations at 291 nm ( f = 0.05) and 279 nm ( f = 0.05) have metal to dpa ligand charge transfer character, while the excitation at 277 nm ( f = 0.0.03) has the 2-nap-ligand-centered π → π* character, which is qualitatively in agreement with the experimental data (612 nm emission).…”

“…A solution of 2-naphthalene sulfonyl chloride (2.5 mmol, 0.572 g) was added to a solution of N(H)dpa (5 mmol, 0.92 ml) according to a known procedure to obtain N(SO 2 (2-nap))dpa ligand. 43 Brownish yellow colour, plate like crystals suitable for X-ray diffraction were obtained (0.662 g, 68%). 1 H NMR, UV-vis and FTIR data were matched with previously reported data.…”

“…59 1 H NMR data for the ligands utilized in this study have been previously reported. 25,43 Therefore, the signals related to the platinum complexes were assigned accordingly. 1 H NMR spectra for all compounds are depicted in Fig.…”

“…A similar pattern was observed for Pt vs. Re complexes carrying the naphthyl derivatives. 43 For all the signals in the ligand upon coordination to Pt, signicant downeld chemical shis are observed (Table 3). These chemical shis provide a strong evidence for the formation of metal complex.…”