Fluorescent Conjugated Polyelectrolytes for Biomacromolecule Detection

Abstract

Water‐soluble conjugated polymers have attracted much attention in the biosensor community because of recent exciting experimental results. The transfer of excitation energy along the whole backbone of the conjugated polymer to the reporter results in an amplified fluorescence signal, which makes them useful as optical platforms in highly sensitive chemical and biological sensors. In this Research News Article, we provide a brief review of recent developments in this field, focusing especially on the application of water‐soluble optical conjugated polymers in biomacromolecule (DNA and protein) detection.

Sensitive fluorescent sensing for DNA assay

“…CPs are water-soluble polymers that contain a pdelocalized backbone bearing pendant ionic functionalities [47][48][49][50]. Some CPs, including polythiophene [51], poly-fluorene [52], poly (p-phenylenevinylene) [53], poly (p-phenylene ethynylene) [54], and oligonucleotidefunctionalized polymer, were synthesized and their sensing properties were investigated.…”

Molecularly Imprinted Polymers (PIMs) in Biomedical Applications

“…To date molecularly imprinted polymers have been successfully used with most types of transduction platforms and a range of methods have been used to bring about close integration of the platform with the polymer. During the past ten years, the literatures on the development of MIP-based sensors, in particularly electrochemical (Riskin et al, 2008;Kan et al, 2008a) and optical (McDonagh et al, 2008;Basabe-Desmonts et al, 2007;Li et al, 2007;Feng et al, 2008) sensors, have been dramatically growing.…”

Carbon Nanotubes – Imprinted Polymers: Hybrid Materials for Analytical Applications

“…During the past ten years, the literatures on the development of MIP-based sensors, in particularly electrochemical (Riskin et al, 2008;) and optical (McDonagh et al, 2008;BasabeDesmonts et al, 2007;Li J. et al, 2007a;Feng et al, 2008) sensors, have been dramatically growing (Nilsson et al, 2007;Ramanavicius et al, 2006). It was found that the manufacture of composites consisting of molecularly imprinted conducting polymers results in obtaining materials that exhibit both predetermined selective molecular recognition and electrical conductivity (Deore et al, 2000).…”