Fluorescent carbon nanodots for targeted in vitro cancer cell imaging

Carbon quantum dots and their biomedical and therapeutic applications: a review

“…Several researchers have successfully used the CQDs for in vitro bioimaging. 52,[101][102][103][104][105][106][107][108][109][110][111][112][113] In several applications, the QDs are preferred to organic dyes and uorescent proteins due to the enhanced brightness, photostability, imaging sensitivity, and good resistance to metabolic degradation. 114 Semiconductor QDs such as CdSe with their core-shell structure (e.g.…”

Folic acid-conjugated carbon dots as green fluorescent probes based on cellular targeting imaging for recognizing cancer cells

“…Zhang et al 28 embellished blue uorescent CDs with folic acid through electrostatic interactions for effective targeted imaging of FR-positive HeLa and HepG-2 cancer cells. Recently, Kushwaha et al 29 demonstrated the dual targeting ability of a uorescence nanoprobe using uorescent CDs covalently conjugated with folic acid; these CDs displayed excellent MCF-7 breast cancer cell cytoplasm and nucleus targeting performance. To our knowledge, the quantum yields of current folate receptor-targeted uorescent CDs are less than 10%.…”

Fluorescent carbon dots driven from ayurvedic medicinal plants for cancer cell imaging and phototherapy

“…However, the known reported methods appear to be little too expensive and time consuming that produce the relatively low to high product yield of these dots. Additionally, controlling the optical property and biocompatibility of carbon quantum dots without surface functionalization is a challenging task so far [41, 42, 43, 44, 45]. Thus, the simplified and economically sustainable synthesis of biocompatible carbon quantum dots became significant to further their utilization for biomedical applications.…”

“…Here in the present manuscript, we are reporting an reasonably cost-effective and considerably easy route to obtain fluorescent carbon quantum dots [20, 44] from ayurvedic medicinal plants leaves viz., CQDs-1 (obtained from Azadirachta Indica),CQDs-2 (obtained from Ocimum Tenuiflorum) and CQDs-3 (obtained from Tridax Procumbens). The obtained CQDs are characterized by using various physicochemical techniques.…”