Fluorescent Carbon Dots Derived from Maillard Reaction Products: Their Properties, Biodistribution, Cytotoxicity, and Antioxidant Activity

Li, Dongmei; Na, Xiaokang; Wang, Haitao; Xie, Yisha; Cong, Shuang; Song, Yukun; Xu, Xianbing; Zhu, Beiwei; Tan, Mingqian

doi:10.1021/acs.jafc.7b05643

Cited by 88 publications

(71 citation statements)

References 49 publications

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“…Recently, researchers have found that some of the CDs using green carbon sources including green tea, garlic, pepper, lysine and so on or drugs such as aspirin may get both fluorescent characters and bioactivities such as anticancer, antioxidant and anti-inflammatory effects. [30][31][32][33][34] These attractive CDs can show significant bioactivities when they are used for tracing and bioimaging in vivo or vitro. It is a fascinating challenge to form the CDs having both biological activities and fluorescent property after high temperature hydrothermal synthesis.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of ginsenoside Re-based carbon dots applied for bioimaging and effective inhibition of cancer cells

Hua

Song

et al. 2018

IJN

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BackgroundFluorescent carbon-based nanomaterials have promising properties such as biosensing, cell imaging, tracing and drug delivery. However, carbon dots (CDs) with specific inherent biological functions have not been investigated. Ginsenosides are the components with multiple bioactivities found in plants of the genus Panax, which have attracted a lot of attention for their anticancer effect.Materials and methodsIn this study, we prepared a kind of novel photoluminescent CDs from ginsenoside Re by one-step hydrothermal synthesis method. The conventional methods including transmission electron microscopy, Fourier transform infrared spectroscopy, HPLC and fluorescence spectrum were used for characterization of CDs. In vitro anticancer effect was investigated by cytotoxicity assay, flow cytometry and Western blot analysis.ResultsThe as-prepared Re-CDs had an average diameter of 4.6±0.6 nm and excellent luminescent properties. Cellular uptake of Re-CDs was facilitated by their tiny nanosize, with evidence of their bright excitation-dependent fluorescent images. Compared with ginsenoside Re, the Re-CDs showed greater inhibition efficiency of cancer cell proliferation, with lower toxicity to the normal cells. The anticancer activity of Re-CDs was suggested to be associated with the generation of large amount of ROS and the caspase-3 related cell apoptosis.ConclusionHopefully, the dual functional Re-CDs, which could both exhibit bioimaging and anticancer effect, are expected to have great potential in future clinical applications.

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Section: Introductionmentioning

confidence: 99%

Synthesis of ginsenoside Re-based carbon dots applied for bioimaging and effective inhibition of cancer cells

Hua

Song

et al. 2018

IJN

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“…Here, we report first a mild and one-step synthesis of 2,2'-(ethylenedioxy)bis(ethylamine)functionalized GQDs via amine-assisted cutting of GO while using hydrogen peroxide H 2 O 2 at 80 • C. The green-yellow emitting GQDs that were obtained exhibit a high PL quantum yield of 22% and a PL emission wavelength dependent on the excitation wavelength. Next, we demonstrate that GQDs could trap Fe(II) and Cu(II) ions and scavenge radicals like the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS •+ ) due to their reducing activity, owing to the radical scavenging properties of the sp 2 -carbon domains [42][43][44][45][46][47][48] and the chelation ability of both oxygen-containing functions and of the 2,2'-(ethylenedioxy)bis(ethylamine) moieties [49][50][51].…”

Section: Introductionmentioning

confidence: 92%

One-Step Synthesis of Diamine-Functionalized Graphene Quantum Dots from Graphene Oxide and Their Chelating and Antioxidant Activities

et al. 2020

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2,2’-(Ethylenedioxy)bis(ethylamine)-functionalized graphene quantum dots (GQDs) were prepared under mild conditions from graphene oxide (GO) via oxidative fragmentation. The as-prepared GQDs have an average diameter of ca. 4 nm, possess good colloidal stability, and emit strong green-yellow light with a photoluminescence (PL) quantum yield of 22% upon excitation at 375 nm. We also demonstrated that the GQDs exhibit high photostability and the PL intensity is poorly affected while tuning the pH from 1 to 8. Finally, GQDs can be used to chelate Fe(II) and Cu(II) cations, scavenge radicals, and reduce Fe(III) into Fe(II). These chelating and reducing properties that associate to the low cytotoxicity of GQDs show that these nanoparticles are of high interest as antioxidants for health applications.

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“…Furcellaran film, with the addition of CQDs, showed the ability to chelate metal ions at a level of 18.63%. According to data from literature, CQDs' chelating properties increase with an increasing concentration of this compound [57]. Further research is required to assess the effect of increasing the addition of CQDs to furcellaran films on their antioxidant activity.…”

Section: Antioxidant Activity Of Filmsmentioning

confidence: 99%

Nanocomposite Furcellaran Films—the Influence of Nanofillers on Functional Properties of Furcellaran Films and Effect on Linseed Oil Preservation

Jamróz

Kopel

Tkaczewska³

et al. 2019

Polymers

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Nanocomposite films that were based on furcellaran (FUR) and nanofillers (carbon quantum dots (CQDs), maghemite nanoparticles (MAN), and graphene oxide (GO)) were obtained by the casting method. The microstructure, as well as the structural, physical, mechanical, antimicrobial, and antioxidant properties of the films was investigated. The incorporation of MAN and GO remarkably increased the tensile strength of furcellaran films. However, the water content, solubility, and elongation at break were significantly reduced by the addition of the nanofillers. Moreover, furcellaran films containing the nanofillers exhibited potent free radical scavenging ability. FUR films with CQDs showed an inhibitory effect on the growth of Staphylococcus aureus and Escherichia coli. The nanocomposite films were used to cover transparent glass containers to study the potential UV-blocking properties in an oil oxidation test and compare with tinted glass. The samples were irradiated for 30 min. with UV-B and then analyzed for oxidation markers (peroxide value, free fatty acids, malondialdehyde content, and degradation of carotenoids). The test showed that covering the transparent glass with MAN films was as effective in inhibiting the oxidation as the use of tinted glass, while the GO and CQDs films did not inhibit oxidation. It can be concluded that the active nanocomposite films can be used as a desirable material for food packaging.

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Fluorescent Carbon Dots Derived from Maillard Reaction Products: Their Properties, Biodistribution, Cytotoxicity, and Antioxidant Activity

Cited by 88 publications

References 49 publications

Synthesis of ginsenoside Re-based carbon dots applied for bioimaging and effective inhibition of cancer cells

Synthesis of ginsenoside Re-based carbon dots applied for bioimaging and effective inhibition of cancer cells

One-Step Synthesis of Diamine-Functionalized Graphene Quantum Dots from Graphene Oxide and Their Chelating and Antioxidant Activities

Nanocomposite Furcellaran Films—the Influence of Nanofillers on Functional Properties of Furcellaran Films and Effect on Linseed Oil Preservation

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