Fluorescent Bioactive Corrole Grafted-Chitosan Films

Abstract

Transparent corrole grafted-chitosan films were prepared by chemical modification of chitosan with a corrole macrocycle, namely, 5,10,15-tris(pentafluorophenyl)corrole (TPFC), followed by solvent casting. The obtained films were characterized in terms of absorption spectra (UV-vis), FLIM (fluorescence lifetime imaging microscopy), structure (FTIR, XPS), thermal stability (TGA), thermomechanical properties (DMA), and antibacterial activity. The results showed that the chemical grafting of chitosan with corrole units did not affect its film-forming ability and that the grafting yield increased with the reaction time. The obtained transparent films presented fluorescence which increases with the amount of grafted corrole units. Additionally, all films showed bacteriostatic effect against S. aureus, as well as good thermomechanical properties and thermal stability. Considering these features, promising applications may be envisaged for these corrole-chitosan films, such as biosensors, bioimaging agents, and bioactive optical devices.

Recently developed applications for natural hydrophilic polymers

“…Corrole grafted transparent chitosan films demonstrated fluorescence and bacteriostatic effects against S. aureus, in addition to good thermomechanical properties [139].…”

“…In this review, the recent progress highlights are described with concerning the basic structures, properties, and property modifications through chemical grafting, e.g., phenol-based A c c e p t e d M a n u s c r i p t antioxidant property, corrosion property, enzymatic inhibitions of polyphenols, blending, mixing, etc [139][140][141][142]. These research activities are mainly grouped into three beneficial categories, food, environmental, and medical fields, which provides an opportunity for manipulating physicochemical characteristics.…”

Magnetite–Corrole Hybrid Nanoparticles

“…Recent developments on chemical functionalization approaches of corroles have given new impetus to the application of these compounds in several areas [1][2][3][4][5][6]. For example, they are used in the therapeutic field as inactivation agents for bacteria, viruses, and fungi; contrast agents for biomedical imaging; photosensitizers for photodynamic therapy to fight cancer [7][8][9][10][11][12][13][14][15][16]; and also as catalysts [5] and sensors [4].…”

Preparation of a Novel Chitosan/Glycerol/Matrine Drug-Loading Film and the Study of Its Release Behavior in Vitro

“…Because of its nontoxic and biodegradable, good drug compatibility and film-forming [3], good anti-inflammatory hemostasis [4] and antibacterial sterilization [5], tissue healing promoting and other pharmacological effects [6,7], chitosan (CS) is widely used in the medical field. Chitosan sustained-release film is a film of a several millimeters made through evenly dispersing drugs in chitosan solution.…”