1969
DOI: 10.1016/s0022-3476(69)80368-9
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Fluorescent antibody test for neonatal congenital syphilis: A progress report

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Cited by 27 publications
(6 citation statements)
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“…The infant was number one of twins; the other baby was stillborn and macerated. In other studies, FTA-ABS tests for IgM have been found to be positive whenever an infant had obvious syphilis (1,8,19,20), and it is difficult to explain why all the IgM tests were negative. The child did not have rheumatoid factor, which was found in all tested children with definite congenital syphilis.…”
Section: Flagellum -Elisa Igmmentioning
confidence: 87%
See 1 more Smart Citation
“…The infant was number one of twins; the other baby was stillborn and macerated. In other studies, FTA-ABS tests for IgM have been found to be positive whenever an infant had obvious syphilis (1,8,19,20), and it is difficult to explain why all the IgM tests were negative. The child did not have rheumatoid factor, which was found in all tested children with definite congenital syphilis.…”
Section: Flagellum -Elisa Igmmentioning
confidence: 87%
“…of fetal antibody production and therefore infection, because IgM and IgA antibodies do not cross the intact placenta. The reference method for detection of specific IgM antibodies in congenital syphilis is the fluorescent treponemal antibody absorption (FTA-ABS) test, using a fluorescence-conjugated anti-human IgM antibody (1,7,(19)(20)(21). The FTA-ABS IgM test is not widely used because it is laborious and because there have been doubts about both the specificity and the sensitivity of the test (4, 7,9,16).…”
mentioning
confidence: 99%
“…FTA-ABS 19S IgM test. An older technique for the diagnosis of congenital syphilis that remains in the investigational status is the FTA-ABS 19S IgM test (1,42,92,125,139,185,186). The FTA-ABS 19S IgM test is not available in kit form, and matching the reagents to be used in the test is extremely difficult.…”
Section: Treponemal Testsmentioning
confidence: 99%
“…Serological tests designed to diagnose or exclude congenital syphilis have been described by many authors (Scotti and Logan, 1968;Scotti, Logan, and Caldwell, 1969;Alford, Polt, Cassady, Straumfjord, and Remington, 1969;Sepetjian, Guerraz, Monier, Nivelon, and Thivolet, 1970;Mamunes, Cave, Budell, Anderson, and Steward, 1970). All these workers used a modified fluorescent treponemal antibody (FTA) technique demonstrating IgM class antitreponemal antibody.…”
mentioning
confidence: 99%