Fluorescent-Antibody Test for Cytomegalovirus Macroglobulin

Hanshaw, James B.; Steinfeld, Harvey J.; White, Cherie J.

doi:10.1056/nejm196809122791102

Cited by 143 publications

(35 citation statements)

References 8 publications

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“…Specificity of the immunofluorescent test for CMV infection is confirmed by Hanshaw et al (1968). The most reliable method of detecting congenital CMV infection in newborn infants is virus isolation, but in case of negative virus isolation congenital CMV infection would not be deniable, because there would be a small amount of virus excretion in congenital CMV infection.…”

Section: Discussionmentioning

confidence: 96%

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Studies of Cytomegalovirus Infection in Newborn Infants

Nakao

Chiba

Ohsaki

et al. 1971

Tohoku J. Exp. Med.

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Section: Discussionmentioning

confidence: 96%

“…Recentry Hanshaw et al (1968) reported that CMV macroglobulin test was a convenient and sensitive method for the detection of cytomegalic inclusion disease.…”

mentioning

confidence: 99%

Studies of Cytomegalovirus Infection in Newborn Infants

Nakao

Chiba

Ohsaki

et al. 1971

Tohoku J. Exp. Med.

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“…The rate of identification of pregnancies at risk therefore, as judged by virus excretion by the neonatal infant was 4/756 or 5 3 per 1000 in this study: this can be compared with the rate of 88 per 1000 unmarried mothers found in two studies in 1967 to 1969 (Collaborative Study, 1970) and from 1969. Ifthe two babies with IgM in their neonatal serum, but who failed to yield virus (Hanshaw, Sternfield & White, 1968), are also considered as congenital infections this rate would be 7 9 per 1000.…”

Section: Discussionmentioning

confidence: 99%

Identification of pregnancies at risk from cytomegalovirus infection

Silva

Kampfner

Lister

et al. 1977

J. Hyg.

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SUMMARYThe fluorescent antibody technique was used for the identification of specific cytomegalovirus IgM in the sera of twenty-four of 1065 unmarried pregnant women. Seventeen of them were followed to term and five infected infants were identified. Two other infants had CMV IgM in neonatal serum samples but virus excretion was not demonstrated. The congenital infection rate in this study was 5-3 per 1000 births by virus excretion and 7'9 per 1000 if cases with specific IgM are included; from previous studies a rate of 8*8 per 1000 was expected. The reasons for the lack of relationship between specific IgM in the mothers' serum and infected babies is discussed.

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“…HBs Ag, its antibody (anti-HBs) and anti-HAV were determined by ra dioimmunoassay Ausria II, Ausab, Havab, Abbott Laboratories). In patients with acute hepatitis and no serological evidence of hep atitis A or B, infection with cytomegalovirus or Epstein-Barr virus were excluded using an immunofluorescence technique [9] and an ox cell hemolysin test [10], respectively. Serum alanine amino trans ferase (ALAT) and ALP were assayed with an autoanalyzer.…”

Section: Methodsmentioning

confidence: 99%

Autoantibodies to Tamm-Horsfall Protein in Acute and Chronic Hepatitis

Lindberg¹,

Fasth²,

Norkrans³

et al. 1983

Int Arch Allergy Immunol

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The levels of antibodies of the IgG, IgA and IgM class against the Tamm-Horsfall glycoprotein (anti-THP) were determined in 108 patients with the following diagnoses: acute hepatitis A, acute hepatitis B, acute hepatitis non-A non-B, chronic hepatitis B, chronic hepatitis non-A non-B and chronic autoimmune hepatitis. The mean levels of antibodies of the IgM class were higher in all types of hepatitis than in healthy controls, while the mean levels of anti-THP of the IgA and IgG class were increased in acute hepatitis B only. 13 of 20 patients (65%) with acute hepatitis B exhibited increased levels of anti-THP of the IgA class compared to 6–18% of the patients in the other categories. The increased levels of anti-THP of the IgA class could not be attributed to elevated serum IgA but instead were correlated with the levels of serum aminotransferase. The possible impact of this particular association of anti-THP with acute hepatitis B is discussed.

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Fluorescent-Antibody Test for Cytomegalovirus Macroglobulin

Cited by 143 publications

References 8 publications

Studies of Cytomegalovirus Infection in Newborn Infants

Studies of Cytomegalovirus Infection in Newborn Infants

Identification of pregnancies at risk from cytomegalovirus infection

Autoantibodies to Tamm-Horsfall Protein in Acute and Chronic Hepatitis

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