Fluorescent Antibodies in Genital Candidiasis

Rohatiner, J. J.; Grimble, A.

doi:10.1111/j.1471-0528.1967.tb03993.x

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…The fluorescent antibody test was carried out on 51 of the patients in the present study; and 16 (32 per cent) were found to have a positive test at a dilution of 1/32 or more. In a previous study, 30 per cent of patients had positive fluorescent tests (Rohatiner and Grimble, 1967).…”

Section: Resultsmentioning

confidence: 79%

“…None of these authors except Grounds, rompkins and Francis based the incidence of candidial infection in their patients on controlled and acceptable evidence. On the other hand Grimble (1966), Thiery and Vandekerckhove (1967), a large survey by the World Health Organization (1966), Rohatiner and Grimble (1967) and Morris and Morris (1969) were unable to confirm an increased incidence of genital candidasis in women taking oral contraceptives. Peel and Potts (1969) state: "In a few cases the Pill aggravates or precipitates moniliasis.…”

Section: Discussionmentioning

confidence: 99%

“…Samples of faeces were also cultured on Sabouraud medium, to exclude alimentary candida. Blood was taken for fluorescent tests for circulating antibody against candida (Rohatiner and Grimble, 1967). The patients were fully examined clinically to eliminate any general disease, and cytological smears were examined routinely.…”

Section: Present Studymentioning

confidence: 99%

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Genital Candidas1s and Oral Contraceptives

Rohatiner

Grimble

1970

BJOG

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Summary In spite of contrary reports this study confirms the view of the majority of workers that the incidence of candidial vulvo‐vaginitis is not greater in women who take the contraceptive pill than in those who do not and shows that with the combined type of oral contraceptive the dose of oestrogen or convertible progestogen is more important than their relative amounts in contributing to the presence of Candida.

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Section: Resultsmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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Genital Candidas1s and Oral Contraceptives

Rohatiner

Grimble

1970

BJOG

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“…There has recently been a suggestion that genital candidiasis increases in the women taking the steroid contraceptive pill. In one study among women who had been taking the pill for upwards of a year (Rohatiner & Grimble 1967), no such increase could be detected, despite the fact that two smaller studies arriving at the opposite conclusion had appeared in print.…”

Section: Urethritis Cervicitis and Vaginitis In Men And Womenmentioning

confidence: 96%

The Venereological Scene

Grimble

1968

Int J Clinical Practice

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Differenzierung und diagnostische Bedeutung der Immunglobulinklassen humoraler Antikörper gegen Zellwandantigene der Sproßzellen‐und Myzelphase von Candida albicans Differentiation and diagnostic significance of immunoglobulin classes of antibodies against cell wall antigens of yeast and mycelial phase of Candida albicans

Ansorg

Gunesch

Bandelow

et al. 1977

Mycoses

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Zusammenfassung Mit der indirekten Immunfluoreszenzreaktion werden Antikörper gegen Zellwand‐antigene der Sproßzellenphase von Candida albicans in den Immungloublinklassen G, M, A und E nachgewiesen. Die durchschnittliche Titerhöhe bzw. die Nachweishäufigkeit dieser Antikörper steigt nach dem Grad der Infektion in der Reihenfolge Normalpersonen, Keimträger, mucocutane Candida‐Mykosen, tiefe Candida‐Mykosen an, wobei sowohl bei Gesunden als auch bei Erkrankten die Antikörper der Klasse G vorherrschend sind. Infolge der starken Streubreite der Einzelwerte erlauben weder die IgG‐Antikörper noch die IgA‐Antikörper eine hinreichend sichere Differenzierung zwischen oberflächlichen und tiefen Candida‐Mykosen. Demgegenüber liefert die Bestimmung der IgM‐Antikörper für die Differentialdiagnose und die Verlaufskontrolle tiefer Candida‐Mykosen aussagekräftige Resultate. Eindeutige Beziehungen zwischen dem Nachweis von IgE‐Antikörpern und der Symptomatik der Patienten werden nicht festgestellt. Bei Aussprossung der Sproßzellen bleibt die Reaktionsfähigkeit gegenüber IgG‐Anti‐körpern konstant, sie vermindert sich aber mit zunehmender Elongation der Zellen gegen‐über IgA‐, IgM‐ und IgE‐Antikörpern. Antikörper gegen die Zellwandantigene der voll entwickelten Myzelphase werden somit nahezu ausschließlich in der Immunglobulin‐klasse G vorgefunden. Offensichtlich ist der Wechsel von Sproßzellenphase zu Myzelphase mit einer partiellen qualitativen oder quantitativen Änderung der Zellwandantigene kombidert. Für die Serodiagnostik der Candida‐Mykosen sind die Zellwandantigene der Myzelphase wegen ihrer verminderten Reaktionsbreite als Testantigen weniger geeignet als die Zellwandantigene der Sproßzellenphase. Summary Using the indirect immunofluorescence reaction, antibodies against cell wall antigens of the yeast phase of Candida albicans are detected in the immunoglobulin classes G, M, A and E. The average titres respectively the frequency of occurrence of these antibodies increase according to the degree of infection in the sequence: control subjects, carriers, patients with mucocutaneous and patients with systemic Candida mycosis. In both healthy subjects and patients with clinical Candida mycosis antibodies of the IgG class predominate. Because of the large spread of individual titres neither IgG‐ nor IgA‐antibodies allow to differentiate superficial and systemic Candida mycosis with sufficient accuracy. The determination of IgM‐antibodies, however, provides reliable results for the differential diagnosis and control of the course of systemic Candida mycosis. A definite correlation between IgE‐antibodies and clinical symptoms is not observed.

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Fluorescent Antibodies in Genital Candidiasis

Cited by 4 publications

References 17 publications

Genital Candidas1s and Oral Contraceptives

Genital Candidas1s and Oral Contraceptives

The Venereological Scene

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