Fluorescent and magnetic stellate mesoporous silica for bimodal imaging and magnetic hyperthermia

Abstract

kHz and 357 Gauss (or 28.5 kA.m-1) display an outstanding 65% cell death at a very low iron concentration (1.25 μg Fe.mL-1), challenging current magnetic hyperthermia nanosystems. Furthermore, at the particularly demanding conditions of clinical use with quite low field/frequency (100 kHz, 117 Gauss or 9.3 kA.m-1), magnetic hyperthermia combined with the delivery of chemotherapeutic drug, doxorubicin, allowed 46% cell death, which neither the drug nor the NPs alone yielded, evidencing thus the synergistic effect of this combined treatment.

Orienting the Pore Morphology of Core-Shell Magnetic Mesoporous Silica with the Sol-Gel Temperature. Influence on MRI and Magnetic Hyperthermia Properties

“…18 nm diameter are known to have superparamagnetic behavior at room temperature. Such 18 nm IO NPs were shown to be suitable for magnetic hyperthermia and MRI applications [ 35 , 38 , 39 , 40 ]. MS shells of various morphology were thus formed around magnetic core redispersed in chloroform by phase transfer in CTATos surfactant aqueous solution.…”

“…In our previous works, we have recently developed various functionalization strategies using synthesized stellate MS NPs to develop innovative nanomaterials for luminescence bioimaging in vivo [ 33 ] or efficient chelating metal capture in a biological media [ 34 ]. MS stellate shells were also deposited around iron oxide NPs for combined imaging and hyperthermia applications [ 35 ] or to ensure formulation of a new generation of magnetic glasses [ 36 ]. In all these examples, the stellate morphologies were performed at the same temperature synthesis set at of 75–80 °C, which determine similar stellar morphology and pore size.…”

Mesoporous Silica Nanoparticles in Bioimaging

“…SPION core/MSN shell nanocomposites are an alternative choice as multi-modal MSN-based imaging systems and such adducts have been reported with additional OI capabilities by grafting CdSe/ZnS QDs, which have an emissive wavelength of 630 nm, within the silica pore channels [ 175 ]. These particles were also functionalised with HSA to improve biocompatibility and blood circulation time.…”

Nanocomposite Polymer Scaffolds Responding under External Stimuli for Drug Delivery and Tissue Engineering Applications

“…Core–shell NPs consisting of a core with a high magnetic anisotropy and of a shell with a small magnetic anisotropy displayed a very important antitumor effect induced by MH . Otherwise, when iron oxide NPs with a mean diameter of ≈22 nm coated with dendron molecules display an SAR of 120 and 395 W g −1 Fe with a field amplitude of 150 G (12 kA m −1 ) and a frequency of 395 and 796 kHz, respectively; the same NPs coated with a silica shell presented an SAR of 120 and 209 W g −1 Fe , respectively . Doping of iron oxide with cobalt, zinc, or manganese is also a way to improve heating properties .…”