Fluorescent Ag clusters conjugated with anterior gradient-2 antigen aptamer for specific detection of cancer cells

Lan, Jinze; Wu, Xiaoxia; Luo, Liang; Liu, Jing; Yang, Lingyan; Wang, Fu

doi:10.1016/j.talanta.2018.12.089

Cited by 19 publications

(20 citation statements)

References 39 publications

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“…Various types of surface modication of metal NCs, such as aptamer, specic peptides, glucose, DNA, and folic acid have been developed for efficient delivery of the metal NCs to the target (e.g., cancerous tumors) for in vivo applications. [151][152][153][154][155][156] Further studies involving active targeting of metal NCs would be important for in vivo PDT applications.…”

Section: Discussionmentioning

confidence: 99%

Photo/electrocatalysis and photosensitization using metal nanoclusters for green energy and medical applications

2020

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Section: Discussionmentioning

confidence: 99%

Photo/electrocatalysis and photosensitization using metal nanoclusters for green energy and medical applications

2020

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“…The probe was synthesized by conjugating 12 cytosine bases as Ag nanocluster templates with the 8-OHdG aptamer as a specific indicator (Scheme 1). Compared to our previous work, 28…”

Section: ■ Introductionmentioning

confidence: 70%

Aptamer-Modified Silver Nanoclusters for Fluorescence Detection of Intracellular 8-Hydroxydeoxyguanosine

Lan

Feng

et al. 2020

ACS Appl. Nano Mater.

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8-Hydroxydeoxyguanosine (8-OHdG) is one of the main products of DNA oxidative stress injury and has been widely used for quantitative analyzing ROS levels. However, the intracellular detection of 8-OHdG is rarely reported and could provide for a novel tool for oxidative damage research. Here, a highly fluorescent silver nanocluster was synthesized by conjugating 12 cytosine bases as Ag nanocluster templates with 8-OHdG aptamer as the specific binding target (named 8-OHdG-12C), resulting in a 10-fold increase in fluorescence intensity of the assynthesized probe. The 8-OHdG-12C@AgNCs showed a good fluorescence property and were stable for weeks. In addition, it can visualize intracellular 8-OHdG in a spatiotemporal manner. We used oxidative or reductive inducers of ROS and showed that the probe was located within cells and proportional to the cell oxidative damage induced. Together, these results indicate that 8-OHdG-12C@AgNCs hold great potential for in vivo 8-OHdG detection and may be a useful method to determine how DNA oxidative damage influences cancer cells and apoptosis.

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“…Because Ag nanocrystals have a strong inhibitory effect on a variety of bacteria and show low toxicity to the human body, they are widely used in antibacterial drugs [ 32 ]. In this paper, the antibacterial properties of Fe 3 O 4 @PDA/Ag/PDA core shell nanospheres were studied using Escherichia coli and Staphylococcus aureus as bacterial models [ 33 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

Hybrid Polydopamine/Ag Shell-Encapsulated Magnetic Fe3O4 Nanosphere with High Antibacterial Activity

Fang

Zhang

et al. 2020

Materials

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The bacteria, which usually contaminate water environment, often cause terrible infectious diseases thus seriously threaten people’s health. To meet the increasing requirement of the public health care, an easily separable nanomaterial with sustainable anti-bacteria performance is required. This work reports a Fe3O4@PDA/Ag/PDA core-shell nanosphere in which the Ag nanocrystals immobilized on the magnetic carrier are protected by an external polydopamine (PDA) layer. The magnetic hybrid nanospheres are constructed by a tunable coating method and the particle parameters can be effectively controlled by the experimental condition. The antibacterial potential of the nanospheres is evaluable by using the Staphylococcus aureus and Escherichia coli as the models. The results indicate the Fe3O4@PDA/Ag/PDA core-shell nanospheres have a high antibacterial performance by measuring the minimum inhibitory concentration and the minimum bactericidal concentration. Finally, the product is expected to have a sustainable activity because the protecting PDA layer reduce the releasing rate of the Ag+ ions and the materials can be magnetically recovered from the media after the disinfection procedure.

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Fluorescent Ag clusters conjugated with anterior gradient-2 antigen aptamer for specific detection of cancer cells

Cited by 19 publications

References 39 publications

Photo/electrocatalysis and photosensitization using metal nanoclusters for green energy and medical applications

Photo/electrocatalysis and photosensitization using metal nanoclusters for green energy and medical applications

Aptamer-Modified Silver Nanoclusters for Fluorescence Detection of Intracellular 8-Hydroxydeoxyguanosine

Hybrid Polydopamine/Ag Shell-Encapsulated Magnetic Fe3O4 Nanosphere with High Antibacterial Activity

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