Fluorescence visualization improves the detection of oral, potentially malignant, disorders in population screening

Simonato, Luciana Estevam; Tomo, Saygo; Navarro, Ricardo Scarparo; Villaverde, Antônio Balbin

doi:10.1016/j.pdpdt.2019.05.017

Cited by 37 publications

(19 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…From the stance of early diagnostics, or in terms of secondary prevention, to be exact, where primary-care doctors are employed mostly, the detection of precancerous and malignant tumors in the main group (using the new method) featured significant differences compared to the traditional method. A number of previous studies claim that visual examination cannot be viewed as a diagnostic test when it comes to differential diagnostics, so there are also additional fluorescent and a number of other tests used, which, given our observations, proved effective when combined with the available conventional traditional ones [22,24,25,26].…”

Section: Table 2 Comparative Features (%) Of the Disease Symptoms Identified Through The Clinical Examination The Main Group (M1) And Thementioning

confidence: 62%

Improved Diagnosisfor Oral Mucosal Tumorsin the Dentist’s Office

Postnikov¹,

Gabrielyan²,

Trunin³

et al. 2021

AREM

View full text Add to dashboard Cite

Based on currently available literature, clinical examination remains the major method when handling cases of suspected malignancy. However, this method does not allow diagnosing cancer, due to which a large group of patients with possible oral mucosa cancer are referred to an oncologist. The search and use of affordable non-invasive methods for early diagnosis of oral mucosa tumors is an urgent issue facing the health system. The study involved analyzing 134 records of outpatients examined at the Samara Regional Oncological Clinic who were referred by dentists within 2014-2019 from the local polyclinic in Samara due to detection of tumors in oral mucosa and who underwent a biopsy. The patients were divided into two groups according to the examination methods. The inclusion criteria were: detection of various superficial oral mucosa neoplasms; referral from the dentist. The exclusion criteria were as follows: patients with submucosal oral cavity neoplasms referred to the oncologist by other medical specialists or self-referred patients. The control group included 63 patients who, after a conventional examination (including interview, examination, palpation), underwent an incisional biopsy followed by morphological examination at the oncologist’s office. In the major group, in 71 patients at their respective initial dental appointments a special examination algorithm was applied. This algorithm entailed an assessment of the identified risk factors. Indications for biopsy were identified using the histological verification index (HVI). Apart from the conventional examination methods (interview, examination, palpation), autofluorescence stomatoscopy was used, this being done for the purpose of differential diagnostics of inflammation, precancerous and malignant issues, depending on the glow type. In the main group, the initial stages of oral mucosa cancer were detected in 17 patients after biopsy; in the control group – in 4 patients (p=0.004). The developed algorithm used for scoring the patient’s clinical examination data combined with autofluorescence stomatoscopy allowed diagnosing accurately (90% of reliability) precancerous and cancerous diseases, as well as to use invasive research methods (biopsy) strictly following the indications. Aim of study: to improve diagnosis of oral mucosa neoplasms through improvement of the examination algorithm.

show abstract

Section: Table 2 Comparative Features (%) Of the Disease Symptoms Identified Through The Clinical Examination The Main Group (M1) And Thementioning

confidence: 62%

Improved Diagnosisfor Oral Mucosal Tumorsin the Dentist’s Office

Postnikov¹,

Gabrielyan²,

Trunin³

et al. 2021

AREM

View full text Add to dashboard Cite

show abstract

“…20 Dessa forma, podemos verificar a importância da educação continuada visando a capacitação dos profissionais envolvidos, os métodos de diagnósticos no reconhecimento das condições cancerizáveis e sobre o encaminhamento responsável, é de extrema importância. 21,22…”

Section: Discussionunclassified

Lesões bucais diagnosticadas na campanha de prevenção do câncer bucal no município de Fernandópolis/SP no ano de 2019 / Oral lesions diagnosed in the oral cancer prevention campaign in the city of Fernandópolis/SP in 2019

Oliveira¹,

Marchiolli²,

Oliveira³

et al. 2021

Braz. J. Hea. Rev.

Self Cite

View full text Add to dashboard Cite

RESUMOOBJETIVO: O objetivo desse trabalho foi descrever os resultados da Campanha de Prevenção do Câncer Bucal no município de Fernandópolis/SP, no ano de 2019. MÉTODOS: Trata-se de um estudo descritivo e quantitativo desenvolvido a partir dos dados obtidos durante a Campanha de Prevenção do Câncer Bucal realizada no município de Fernandópolis/SP, no ano de 2019. RESULTADOS: Em 2019, foram examinadas 946 pessoas, onde 82 (8,7%) apresentaram lesões bucais e foram encaminhadas ao Centro de Especialidades Odontológicas (CEO). Dessas, 68 (82,9%) compareceram para reavaliação. Entre os pacientes reavaliados, nenhum foi diagnosticado com câncer bucal, enquanto outras 55 lesões bucais foram detectadas. CONCLUSÕES: O baixo índice de câncer bucal detectado durante a campanha do ano de 2019 mostrou que a metodologia da Campanha precisa ser revisitada e que busca ativa deve ser ampliada. Além disso, os altos índices de encaminhamento de lesões bucais benignas e variações da normalidade demostraram a necessidade de manter a educação continuada junto aos cirurgiõesdentistas da rede de saúde pública do município.

show abstract

“…Higher sensitivity (but lower specificity) in detecting oral cancer lesions in a cohort of 123 patients with premalignant oral lesions was reported by Rana et al [79]. By including AFI in a population screening for oral cancer and oral potentially malignant disorders, Simonato et al found that AFI had a higher sensitivity (94.4%) and specificity (96.2%) over conventional oral examination (83.3% sensitivity and 95.1% specificity), and should therefore be considered as an adjunctive method for early diagnosis of high-risk oral lesions [80]. These positive findings, indicating additional diagnostic accuracy, could not be reproduced by Koch et al when 78 patients with suspicious oral mucosal lesions were assessed for oral dysplasia and carcinoma using the VELscope [81].…”

Section: Af In Oral Medicinementioning

confidence: 97%

Recent Advances and the Potential for Clinical Use of Autofluorescence Detection of Extra-Ophthalmic Tissues

et al. 2020

View full text Add to dashboard Cite

The autofluorescence (AF) characteristics of endogenous fluorophores allow the label-free assessment and visualization of cells and tissues of the human body. While AF imaging (AFI) is well-established in ophthalmology, its clinical applications are steadily expanding to other disciplines. This review summarizes clinical advances of AF techniques published during the past decade. A systematic search of the MEDLINE database and Cochrane Library databases was performed to identify clinical AF studies in extra-ophthalmic tissues. In total, 1097 articles were identified, of which 113 from internal medicine, surgery, oral medicine, and dermatology were reviewed. While comparable technological standards exist in diabetology and cardiology, in all other disciplines, comparability between studies is limited due to the number of differing AF techniques and non-standardized imaging and data analysis. Clear evidence was found for skin AF as a surrogate for blood glucose homeostasis or cardiovascular risk grading. In thyroid surgery, foremost, less experienced surgeons may benefit from the AF-guided intraoperative separation of parathyroid from thyroid tissue. There is a growing interest in AF techniques in clinical disciplines, and promising advances have been made during the past decade. However, further research and development are mandatory to overcome the existing limitations and to maximize the clinical benefits.

show abstract

Fluorescence visualization improves the detection of oral, potentially malignant, disorders in population screening

Cited by 37 publications

References 21 publications

Improved Diagnosisfor Oral Mucosal Tumorsin the Dentist’s Office

Improved Diagnosisfor Oral Mucosal Tumorsin the Dentist’s Office

Lesões bucais diagnosticadas na campanha de prevenção do câncer bucal no município de Fernandópolis/SP no ano de 2019 / Oral lesions diagnosed in the oral cancer prevention campaign in the city of Fernandópolis/SP in 2019

Recent Advances and the Potential for Clinical Use of Autofluorescence Detection of Extra-Ophthalmic Tissues

Contact Info

Product

Resources

About