Fluorescence, ultrasonic and photoacoustic imaging for analysis and diagnosis of diseases

Chu, Binbin; Chen, Zhiming; Shi, Haoliang; Wu, Xiaofeng; Wang, Houyu; Dong, Fenglin; He, Yao

doi:10.1039/d2cc06654h

Cited by 25 publications

(12 citation statements)

References 192 publications

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“…Currently, several imaging strategies have been exploited and employed for clinical imaging, such as fluorescent, photoacoustic, ultrasonic, magnetic resonance, computed tomography, positron emission tomography, and single photon emission computed tomography imaging. [ 5a,25 ] In this section, the advantages and disadvantages of existing imaging techniques will be discussed briefly.…”

Section: Current Clinical Strategiesmentioning

confidence: 99%

Stimuli‐Actuated Turn‐On Theranostic Nanoplatforms for Imaging‐Guided Antibacterial Treatment

Yang,

Song,

Dong

et al. 2023

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Antibacterial theranostic nanoplatforms, which integrate diagnostic and therapeutic properties, exhibit gigantic application prospects in precision medicine. However, traditional theranostic nanoplatforms usually present an always‐on signal output, which leads to poor specificity or selectivity in the treatment of bacterial infections. To address this challenge, stimuli‐actuated turn‐on nanoplatforms are developed for simultaneous activation of diagnostic signals (e.g., fluorescent, photoacoustic, magnetic signals) and initiation of antibacterial treatment. Specifically, by combining the infection microenvironment‐responsive activation of visual signals and antibacterial activity, these theranostic nanoplatforms exert both higher accurate diagnosis rates and more effective treatment effects. In this review, the imaging and treatment strategies that are commonly used in the clinic are first briefly introduced. Next, the recent progress of stimuli‐actuated turn‐on theranostic nanoplatforms for treating bacterial infectious diseases is summarized in detail. Finally, current bottlenecks and future opportunities of antibacterial theranostic nanoplatforms are also outlined and discussed.

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Section: Current Clinical Strategiesmentioning

confidence: 99%

Stimuli‐Actuated Turn‐On Theranostic Nanoplatforms for Imaging‐Guided Antibacterial Treatment

Yang,

Song,

Dong

et al. 2023

Small

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“…Recent advances in novel fluorescence labeling strategies, combined with high-resolution imaging protocols, enable researchers to investigate the content and biological behavior of EVs in vitro and in vivo, even at the single vesicle level. [18][19][20] Notably, both labeling strategies and analysis tools have merits and demerits for EV research, let alone clinical use. Taking advantage of these properties and optimized analytical systems of EVs could unveil unresolved issues of EV biology.…”

Section: Introductionmentioning

confidence: 99%

Fluorescence labeling of extracellular vesicles for diverse bio-applicationsin vitroandin vivo

Xing

Jiang

et al. 2023

Chem. Commun.

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“…Bioimaging technologies offer tremendous opportunities for noninvasive or minimally invasive monitoring of functional and pathological conditions, thus enabling early diagnosis and more specific therapy which are fundamental for a successful treatment. 1 Among imaging techniques, photoacoustic imaging is emerging as a powerful hybrid modality, able to combine the advantages of both optical and acoustic signals, thus enabling higher temporal and spatial resolution with good sensitivity and deeper penetration depth. 1 Furthermore, it can be easily integrated with a photothermal treatment for theragnostic purposes.…”

Section: Introductionmentioning

confidence: 99%

“…1 Among imaging techniques, photoacoustic imaging is emerging as a powerful hybrid modality, able to combine the advantages of both optical and acoustic signals, thus enabling higher temporal and spatial resolution with good sensitivity and deeper penetration depth. 1 Furthermore, it can be easily integrated with a photothermal treatment for theragnostic purposes. In this context, the development of functional nanomaterials as contrast agents would provide significant improvement of image quality and diagnosis accuracy, 2 greatly expanding the functions of the modality.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Photoacoustic Response by Synergistic Ag–Melanin Interplay at the Core of Ternary Biocompatible Hybrid Silica-Based Nanoparticles

Silvestri,

Armanetti,

Pota

et al. 2023

ACS Appl. Mater. Interfaces

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Photoacoustics (PA) is gaining increasing credit among biomolecular imaging methodologies by virtue of its poor invasiveness, deep penetration, high spatial resolution, and excellent endogenous contrast, without the use of any ionizing radiation. Recently, we disclosed the excellent PA response of a self-structured biocompatible nanoprobe, consisting of ternary hybrid nanoparticles with a silver core and a melanin component embedded into a silica matrix. Although preliminary evidence suggested a crucial role of the Ag sonophore and the melanin-containing nanoenvironment, whether and in what manner the PA response is controlled and affected by the self-structured hybrid nanosystems remained unclear. Because of their potential as multifunctional platforms for biomedical applications, a detailed investigation of the metal–polymer–matrix interplay underlying the PA response was undertaken to understand the physical and chemical factors determining the enhanced response and to optimize the architecture, composition, and performance of the nanoparticles for efficient imaging applications. Herein, we provide the evidence for a strong synergistic interaction between eumelanin and Ag which suggests an important role in the in situ-generated metal–organic interface. In particular, we show that a strict ratio between melanin and silver precursors and an accurate choice of metal nanoparticle dimension and the kind of metal are essential for achieving strong enhancements of the PA response. Systematic variation of the metal/melanin component is thus shown to offer the means of tuning the stability and intensity of the photoacoustic response for various biomedical and theranostic applications.

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Fluorescence, ultrasonic and photoacoustic imaging for analysis and diagnosis of diseases

Abstract: Biomedical imaging technology, beneficial for us to peer deeply within living subjects and visually explore the delivery and distribution of agents in livings, is producing tremendous opportunities for early diagnosis...

Cited by 25 publications

References 192 publications

Stimuli‐Actuated Turn‐On Theranostic Nanoplatforms for Imaging‐Guided Antibacterial Treatment

Stimuli‐Actuated Turn‐On Theranostic Nanoplatforms for Imaging‐Guided Antibacterial Treatment

Fluorescence labeling of extracellular vesicles for diverse bio-applicationsin vitroandin vivo

Enhanced Photoacoustic Response by Synergistic Ag–Melanin Interplay at the Core of Ternary Biocompatible Hybrid Silica-Based Nanoparticles

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