Fluorescence ‘turn-on’ probe for nanomolar Zn(ii) detection in living cells and environmental samples

Abstract

Herein, a Schiff base ligand FHE was synthesized by condensing 5-allyl-2-hydroxy-3-methoxybenzaldehyde, a eugenol derivative with a derivative furan-2-carbohydrazide. FHE alone showed low fluorescence signals due to the intramolecular charge transfer...

Imaging of Al3+in plant roots by the interaction with a bisphenol A-based chemosensor

“…These bands were attributed to the intra-ligand p-p*/and n-p* transitions. [21][22][23] Nitrogen and oxygen atoms of the chemosensor bonded with Al 3+ to form a chelate ring. As a result, conjugation in the framework expanded, resulting in new absorption bands in the longer wavelength region.…”

“…The quenching or enhancement of fluorescence is largely associated with the electron transfer or charge transfer at the excited state of a chemosensor. 22,23,[28][29][30] Here, the fluorescence increment of the probe has been ascribed to the formation of this complex (Scheme 2). The low fluorescence of the free probe has been attributed to the isomerization of the CQN bond and the result of intramolecular charge transfer (ICT) in H 4 L. As the cation forms a strong complex with the probe (evident from the large K a value), the CHEF mechanism may contribute to the fluorescence enhancement.…”

Highly sensitive and rapid detection of hypochlorous acid in aqueous media and its bioimaging in live cells and zebrafish using an ESIPT-driven mycophenolic acid-based fluorescent probe

“…The cytotoxic activity of Myco-OCl against a lung cancer cell line (A549) was evaluated by an MTT assay. 23,24,44 In brief, about 7000 cells per well were seeded in 96-well plates and grown in an incubator for 24 h. The stock solution of Myco-OCl (10 mM) in DMSO was used to prepare 0, 5, 10, 25, and 50 µM working solutions using a culture medium, and these solutions were then loaded into the wells containing cells. The cells were then incubated for 24 h followed by treatment with MTT for 2 h in the dark.…”

“…[11][12][13][14][15][16][17][18][19] Among these methods, fluorescent probes have gained immense popularity due to their exceptional sensitivity and superior spatiotemporal resolution, making them attractive noninvasive chemical tools for small molecule analyte determination within biological entities. [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] Despite the proliferation of fluorescent probes for HOCl sensing in biosystems, most of these probes exhibit limited water solubility and are restricted to assays where the solvent is organic or an organic co-solvent. The oxidation capacity of HOCl varies considerably across different solvents.…”

Exploration of Molecular Structure, DFT Calculations, and Antioxidant Activity of a Hydrazone Derivative

“…As a part of our ongoing research on the applications of organic motifs such as Schiff bases and their complexes in the field of chemosensors design and development [ 27 , 28 , 29 , 30 ], herein, we have discussed the synthesis and single X-ray crystallography studies of the Schiff bases, i.e., 4-[(1E)-1-hydrazinylideneethyl]benzene-1,3-diol ( 1 ) and 4,4′-((1E,1′E)-hydrazine-1,2-diylidenebis(ethan-1-yl-1-ylidene))bis(benzene-1,3-diol) ( 2 ) ( Scheme 1 ). Also, the quantum chemical calculations of 2 have been performed using the density functional theory (DFT) and compared with the experimental results.…”