Fluorescence studies of pyrene-labelled, pH-responsive diblock copolymer micelles in aqueous solution

Rutkaitė, Ramunė; Swanson, Linda; Li, Y.; Armes, Steven P.

doi:10.1016/j.polymer.2008.02.007

Cited by 19 publications

(7 citation statements)

References 59 publications

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“…This behaviour has been observed previously in the interior of polymer micelles, for example. 50 Nevertheless, given that the most dramatic effect observed by Meewes et al 42 occurred between [SDS] ¼ 0 mg dm À3 and 10 mg dm À3 significant particle disaggregation is not apparent in the current data.…”

Section: Resultscontrasting

confidence: 57%

Time-resolved fluorescence anisotropy studies of the interaction of N-isopropyl acrylamide based polymers with sodium dodecyl sulphate

et al. 2011

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Section: Resultscontrasting

confidence: 57%

Time-resolved fluorescence anisotropy studies of the interaction of N-isopropyl acrylamide based polymers with sodium dodecyl sulphate

et al. 2011

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“…In an extension of the work using a pyrene probe [166], TRAMs have been performed [180] on a fluorescently labeled DMAEMA-b-DEAEMA block copolymer to detect the onset of micellization. A pyrenyl derivative, located at the DEAEMA block end, allowed motion of this site to be monitored.…”

Section: Block Copolymersmentioning

confidence: 99%

Optical Properties of Polyelectrolytes

Swanson

2010

Photochemistry and Photophysics of Polymer Materials

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A polyelectrolyte can be defined as a macromolecule with ionizable repeat units, which can consequently display pH-dependent behavior when dissolved in aqueous solution.As the term polyelectrolyte can also be extended to encompass natural biopolymers, which contain ionizable groups such as peptides, proteins, and DNA, it is perhaps not surprising that synthetic polyelectrolytes are often used as simple models for more complex biological systems. Indeed, many of the photophyscial techniques discussed in this chapter were developed by biologists and biophysicists interested in the conformational behavior and interactions of biopolymers [1].

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“…In recent years, fluorescent nanoparticles with inherent optical imaging have been investigated extensively in the field of cell imaging, medical diagnostics, and therapy. Moreover, they also have been widely introduced into the drug delivery system, because they could preferentially accumulate in diseased tissues and carry detection signal agents or drugs to monitor and treat the diseases.…”

Section: Introductionmentioning

confidence: 99%

A pH‐responsive self‐fluorescent polymeric micelle as a potential optical imaging probe

Jiang

2018

Polymers for Advanced Techs

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A series of methoxypolyethylene glycol‐terminated self‐fluorescent polyurethane multi‐block copolymers with excellent pH‐responsivity, self‐fluorescence, and biocompatibility are designed and synthesized. In our design, 1, 4‐bis (hydroxyethyl) piperazine is chosen as a pH‐responsive segment which can donate or accept protons in response to the change of environmental pH, and fluorescein isothiocyanate is used as a fluorescent dye conjugated into the micelles to offer self‐fluorescence. The chemical structure of the polyurethane multi‐block copolymers is characterized by nuclear magnetic resonance and Fourier transform infrared spectroscopy. The results of the acid‐based titration, the fluorescence spectrometry, and the ultraviolet visible spectroscopy indicate that the polyurethane multi‐block copolymers own an excellent pH‐buffering capacity responded to the change of pH values and the favorable self‐fluorescence property in an aqueous solution. And the ultraviolet absorption peaks of samples are strengthened with increasing of pH values, indicating that methoxypolyethylene glycol‐terminated self‐fluorescent polyurethane multi‐block copolymer can be a pH‐dependent fluorescent probe in a broad pH range. In addition, the in vitro cytotoxicity test showed that the polyurethane multi‐block copolymer has low cytotoxicity and good biocompatibility, which make it a promising nanoplatform for molecular imaging, diagnosis, and treatment of disease.

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Fluorescence studies of pyrene-labelled, pH-responsive diblock copolymer micelles in aqueous solution

Cited by 19 publications

References 59 publications

Time-resolved fluorescence anisotropy studies of the interaction of N-isopropyl acrylamide based polymers with sodium dodecyl sulphate

Time-resolved fluorescence anisotropy studies of the interaction of N-isopropyl acrylamide based polymers with sodium dodecyl sulphate

Optical Properties of Polyelectrolytes

A pH‐responsive self‐fluorescent polymeric micelle as a potential optical imaging probe

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