Fluorescence studies of crown ether complexes – solvent effects regarding the inclusion properties of host–guest sensor complexes

Schönefeld, Karina; Barann, Anne; Vogel, Kerstin; Feller, K.‐H.; Kunze, Denise; Müller, P.; Weber, Edwin

doi:10.1080/03067310500154221

Cited by 7 publications

(2 citation statements)

References 29 publications

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“…Fluorescence quenching or fluorescence enhancement is employed as an analytical technique [ 12 , 13 ]. The fluorescent labelling of the host molecule complex provides a useful tool for detecting the analyte’s attachment to the host molecule [ 14 , 15 , 16 ]. For example, protein labelling using small molecule-based fluorescent probes is used in various biological experiments and is a valuable technique for determining the expression level and localization of a protein of interest in living cells [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Fluorescent and Phosphorescent Nitrogen-Containing Heterocycles and Crown Ethers: Biological and Pharmaceutical Applications

Ullah

Khan

et al. 2022

Molecules

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Fluorescent molecules absorb photons of specific wavelengths and emit a longer wavelength photon within nanoseconds. Recently, fluorescent materials have been widely used in the life and material sciences. Fluorescently labelled heterocyclic compounds are useful in bioanalytical applications, including in vivo imaging, high throughput screening, diagnostics, and light-emitting diodes. These compounds have various therapeutic properties, including antifungal, antitumor, antimalarial, anti-inflammatory, and analgesic activities. Different neutral fluorescent markers containing nitrogen heterocycles (quinolones, azafluoranthenes, pyrazoloquinolines, etc.) have several electrochemical, biological, and nonlinear optic applications. Photodynamic therapy (PDT), which destroys tumors and keeps normal tissues safe, works in the presence of molecular oxygen with light and a photosensitizing drugs (dye) to obtain a therapeutic effect. These compounds can potentially be effective templates for producing devices used in biological research. Blending crown compounds with fluorescent residues to create sensors has been frequently investigated. Florescent heterocyclic compounds (crown ether) increase metal solubility in non-aqueous fluids, broadening the application window. Fluorescent supramolecular polymers have widespread use in fluorescent materials, fluorescence probing, data storage, bio-imaging, drug administration, reproduction, biocatalysis, and cancer treatment. The employment of fluorophores, including organic chromophores and crown ethers, which have high selectivity, sensitivity, and stability constants, opens up new avenues for research. Fluorescent organic compounds are gaining importance in the biological world daily because of their diverse functionality with remarkable structural features and positive properties in the fields of medicine, photochemistry, and spectroscopy.

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Section: Introductionmentioning

confidence: 99%

Fluorescent and Phosphorescent Nitrogen-Containing Heterocycles and Crown Ethers: Biological and Pharmaceutical Applications

Ullah

Khan

et al. 2022

Molecules

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“…Therefore, here the preparation of chemochips with integrated fluorescence dyes is addressed. The high sensitivity of the fluorimetric methods can be exploited with the help of high-resolution charge-coupled device (CCD) imaging or UV scanners (Schonefeld et al 2005(Schonefeld et al , 2006Thete et al 2008a,b). As the chemochip micro spots are generally prepared on solvent swellable polymer matrix, this leads to various types of morphological changes owing to solvent interaction with the base polymer matrix, which poses a problem of quality control in spot preparation, as well as the morphological changes on the chemospots influence the optical read-out.…”

Section: Introductionmentioning

confidence: 99%

Nanotopographic characterization of spotted micro arrays on polyvinyl alcohol films by high‐resolution long‐range nanoprofiling

et al. 2009

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The nanopositioning and nanomeasuring machine was applied for the nanotopographic characterization of polymer micro spot arrays of fluorimetric chemochips. Chemochips are arrays of fluorescence dyes in a hydrogel matrix with different response behaviors of chemical components determination of chemical and physico-chemical properties of analytes by a pattern recognition approach. For the characterization and quality control of the spots, a nanometer resolution is needed over a scan range of several millimeters. This challenge could be met by use of a scanning probe sensor in connection with a laser interferometer controlled high-precision positioning and measuring device. This way, topographic scans with the resolution of atomic force microscope could be achieved over these demandingly large ranges. The technique was used in order to determine the quality of thin film micro spots made from fluorescence dye solutions on preformed polymer films and also tested for characterization of monomolecular films in the form of micro spots. The nanotopographic measurements reflect the strong influence of solvent/matrix interaction, wetting, swelling and material transport during the application of picoliter droplets in the spotting process. The measurement clarifies the reason for the formation of roughness in the nanometer range by nano-crystal formation in the upper part of polymer film and the rim formation of micro spots during solvent evaporation. The studies show the effect of application of different numbers of droplets in a dispensing series for spot formation and prove the high importance of polymer/solvent interaction for the quality of formed micro spots as well as for spot arrays of monomolecular films.

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Micro‐structured Devices for Chemical Sensing of Flavor and Fragrance

Schimmelpfennig

Dornbusch

Bannert

et al. 2008

Engineering in Life Sciences

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The aim of this study was to design, develop and test an integrated micro‐analytical system. Of special interest are micro‐fluidic and micro‐sensor applications in the field of chemical analysis, such as the optical detection of parameter changes, optical recognition of component profiles and technological micro‐reaction applications. For this purpose, a modular system was developed, which enables the realization of various application cases in an uncomplicated manner, and to execute (via serial or parallel combination of components) usually not compatible tasks. Software components were developed to control the measuring procedure as well as to execute the data interpretation up to a chemometrical discriminant analysis. Application is directed to the production and product control in life sciences mainly for food, natural products, cosmetics and pharmaceutics.

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Fluorescence studies of crown ether complexes – solvent effects regarding the inclusion properties of host–guest sensor complexes

Cited by 7 publications

References 29 publications

Fluorescent and Phosphorescent Nitrogen-Containing Heterocycles and Crown Ethers: Biological and Pharmaceutical Applications

Fluorescent and Phosphorescent Nitrogen-Containing Heterocycles and Crown Ethers: Biological and Pharmaceutical Applications

Nanotopographic characterization of spotted micro arrays on polyvinyl alcohol films by high‐resolution long‐range nanoprofiling

Micro‐structured Devices for Chemical Sensing of Flavor and Fragrance

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