Fluorescence spectroscopy of Candida albicans biofilms in bone cavities treated with photodynamic therapy using blue LED (450 nm) and curcumin

Silva, Francine Cristina da; Rodrigues, Paôlla Layanna Fernandes; Araújo, Thalita Santos Dantas; Santos, Mariana Sousa; Oliveira, Janeide Muritiba de; Rosa, Luciano Pereira; Santos, Gabriel Pinto de Oliveira; Araújo, Bruno Pereira de; Bagnato, Vanderlei Salvador

doi:10.1016/j.pdpdt.2019.05.002

Cited by 12 publications

(8 citation statements)

References 12 publications

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“…PDT showed a significant lethal effect compared to Cur or light alone and the control group. Cur or light alone was not significantly different from the positive control group [35] .…”

Section: Effectivenessmentioning

confidence: 61%

“…were done in suspension (planktonic) and solid media (biofilm). Five studies used only biofilm to evaluate the findings [28,30,[35][36][37] .…”

Section: Search Resultsmentioning

confidence: 99%

“…were provided from the human oral mucosa including people with AIDS, lichen planus and oral candidiasis [27,33,36] . Six studies used only C. albicans to evaluate the antifungal effects of PDT [26,28,31,[35][36][37] . In addition to C. albicans, two studies used bacteria including Streptococcus mutans, E. coli, and Methicillin-resistant Staphylococcus aureus (MRSA) [30,37] One study used seven fungal samples including Candida albicans, Aspergillus niger, Aspergillus flavus, Penicillium griseofulvum, Penicillium chrysogenum, Fusarium oxysporum and Zygosaccharomyces bailii [32] .…”

Section: Type Of Microorganisms and Their Isolationmentioning

confidence: 99%

“…10 studies used low concentrations of Cur (0.005-100 µM) and one study used concentrations of 100-1000 µM Cur [32] . In one study, Cur concentration was reported as 1.5 g / Lit [35] . Toluidine blue with a concentration of 10 µM and erythrosine with a concentration of 100 µM were used in one study [31] .…”

Section: Types Of Psmentioning

confidence: 99%

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Effectiveness of photodynamic therapy with curcumin against Candida species: A systematic review

Limoodi¹,

Khosraviani²,

Moghaddasi³

et al. 2021

Int. J. Appl. Dent. Sci.

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Introduction:In recent years, photodynamic therapy (PDT) has shown an effective role in controlling fungal infections such as oral candidiasis both in laboratory and clinical settings. Curcumin as a natural photosensitizer has antibacterial as well as antifungal effects. The aim of the present study was to evaluate the anti-Candida spp. effects of PDT by using curcumin. Methods: First, the intended keywords were searched in the four following databases: Google Scholar, PubMed, Scopus and Web of Science. The titles were then merged, and the original eligible articles published by the end of 2020 were scrutinized. Results: Out of 167 merged titles, 12 articles (In-vitro, in-vivo: mice & G. mellonella) met the required criteria and were included in the study. The studied Candida spp. were C. albicans, C. dubliniensis, C. glabrata and C. tropicalis. Concentrations of curcumin used in the studies ranged from 0.005 to 1000 µM. The light sources included LED (440-460 nm), diode laser (405, 532, 650 nm) and Xenon lamp (370-680 nm). The results of all studies showed that PDT reduced the colony count and the level of Candida spp. metabolism significantly. PDT efficacy was dependent on curcumin concentration, Candida spp., energy and wavelength of radiations, and it proved more effective in planktonic environments than biofilm environments. Conclusion: PDT using curcumin in a concentration-dependent manner has a potent lethal effect against some Candida spp. and may be considered as a major or adjuvant treatment for some Candida infections.

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“…PDT showed a significant lethal effect compared to Cur or light alone and the control group. Cur or light alone was not significantly different from the positive control group [35] .…”

Section: Effectivenessmentioning

confidence: 61%

“…were done in suspension (planktonic) and solid media (biofilm). Five studies used only biofilm to evaluate the findings [28,30,[35][36][37] .…”

Section: Search Resultsmentioning

confidence: 99%

Section: Type Of Microorganisms and Their Isolationmentioning

confidence: 99%

Section: Types Of Psmentioning

confidence: 99%

See 2 more Smart Citations

Effectiveness of photodynamic therapy with curcumin against Candida species: A systematic review

Limoodi¹,

Khosraviani²,

Moghaddasi³

et al. 2021

Int. J. Appl. Dent. Sci.

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show abstract

“…Nevertheless, PACT in comparison to blue light alone brought about extensive DNA damage, and its repair was inhibited by the use of 13, which appeared to be the mechanism of the antifungal activity of the treatment procedure [156]. Da Silva et al investigated C. albicans biofilms in artificial bone cavities treated with PACT mediated with 450 nm blue LED in combination with 13, using fluorescence spectroscopy [157]. They also searched for a relation between the effectiveness of the photodynamic treatments and the fluorescence spectroscopy images.…”

Section: Curcuminmentioning

confidence: 99%

Photosensitizers Mediated Photodynamic Inactivation against Fungi

Ziental

Mlynarczyk

Czarczyńska-Goślińska

et al. 2021

Nanomaterials

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Superficial and systemic fungal infections are essential problems for the modern health care system. One of the challenges is the growing resistance of fungi to classic antifungals and the constantly increasing cost of therapy. These factors force the scientific world to intensify the search for alternative and more effective methods of treatment. This paper presents an overview of new fungal inactivation methods using Photodynamic Antimicrobial Chemotherapy (PACT). The results of research on compounds from the groups of phenothiazines, xanthanes, porphyrins, chlorins, porphyrazines, and phthalocyanines are presented. An intensive search for a photosensitizer with excellent properties is currently underway. The formulation based on the existing ones is also developed by combining them with nanoparticles and common antifungal therapy. Numerous studies indicate that fungi do not form any specific defense mechanism against PACT, which deems it a promising therapeutic alternative.

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The effects of antimicrobial photodynamic therapy (aPDT) with nanotechnology-applied curcumin and 450nm blue led irradiation on multi-species biofilms in root canals

Ravazzi,

de Jesus,

de Oliveira Santos

et al. 2023

Lasers Med Sci

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Fluorescence spectroscopy of Candida albicans biofilms in bone cavities treated with photodynamic therapy using blue LED (450 nm) and curcumin

Cited by 12 publications

References 12 publications

Effectiveness of photodynamic therapy with curcumin against Candida species: A systematic review

Effectiveness of photodynamic therapy with curcumin against Candida species: A systematic review

Photosensitizers Mediated Photodynamic Inactivation against Fungi

The effects of antimicrobial photodynamic therapy (aPDT) with nanotechnology-applied curcumin and 450nm blue led irradiation on multi-species biofilms in root canals

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