Fluorescence Spectroscopy for Evaluation of Safety Margins in Individuals With Surgically Treated Squamous Cell Carcinoma of the Oral Cavity

Francisco, Ana Lúcia Noronha; Correr, Wagner Rafael; Chulam, Thiago Celestino; Filho, João Gonçalves; Kelner, Natalie; Kurachi, Cristina; Kowalski, Luiz Paulo

doi:10.1016/j.oooo.2013.12.305

Cited by 2 publications

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“…Among various methods, spectroscopy-based approaches like fluorescence, diffuse reflectance, Fourier transformed infrared spectroscopy (FTIR), and Raman spectroscopy (RS) are being actively explored as potential stand alone or adjuvant diagnostic tools. [6][7][8][9][10][11][12] RS represents a unique technique capable of label-free and nondestructively probing endogenous biomolecules, for example, proteins, lipids, carbohydrates, and nucleic acids; to determine highly specific diagnostic information. [9][10][11][12] The current review presents an update of latest developments of application of RS in cervical cancer detection based on cells, ex vivo, in vivo, and therapeutic response monitoring.…”

Section: Introductionmentioning

confidence: 99%

Raman spectroscopy in cervical cancers: An update

Rubina

2015

J Can Res Ther

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Cervical cancer is the third most common cancer among women worldwide. Developing countries contribute more than 80% towards global burden. Over the last 2 decades, Raman spectroscopy (RS) has been actively pursued for cervical cancer detection. In view of latest development in Raman spectroscopic applications in cervical cancers, especially in vivo studies, an update of the same is presented in this article. This articles opens with a brief note on Anatomy of cervix followed by Etiology, and conventional Screening and Diagnosis of Cervical cancers. In subsequent sections, brief description of Theory and Instrumentation of RS is followed by a review of recent developments in cervical cancer detection; with emphasis on cell lines, exfoliated cells, ex vivo and in vivo, and therapeutic response monitoring applications in cervical cancer.

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Section: Introductionmentioning

confidence: 99%

Raman spectroscopy in cervical cancers: An update

Rubina

2015

J Can Res Ther

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“…3,4 Optical spectroscopic techniques, such as fluorescence, infrared (IR), and Raman, have shown potentials in classifying normal and tumor groups in various cancers. [5][6][7][8] Several ex vivo Raman studies have demonstrated the classification of normal, precancerous, and cancerous cervical tissues. [9][10][11][12] The first in vivo Raman study of cervical cancer was reported in 1998.…”

Section: Introductionmentioning

confidence: 99%

In vivoRaman spectroscopy of human uterine cervix: exploring the utility of vagina as an internal control

et al. 2014

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In vivo Raman spectroscopy is being projected as a new, noninvasive method for cervical cancer diagnosis. In most of the reported studies, normal areas in the cancerous cervix were used as control. However, in the Indian subcontinent, the majority of cervical cancers are detected at advanced stages, leaving no normal sites for acquiring control spectra. Moreover, vagina and ectocervix are reported to have similar biochemical composition. Thus, in the present study, we have evaluated the feasibility of classifying normal and cancerous conditions in the Indian population and we have also explored the utility of the vagina as an internal control. A total of 228 normal and 181 tumor in vivo Raman spectra were acquired from 93 subjects under clinical supervision. The spectral features in normal conditions suggest the presence of collagen, while DNA and noncollagenous proteins were abundant in tumors. Principal-component linear discriminant analysis (PC-LDA) yielded 97% classification efficiency between normal and tumor groups. An analysis of a normal cervix and vaginal controls of cancerous and noncancerous subjects suggests similar spectral features between these groups. PC-LDA of tumor, normal cervix, and vaginal controls further support the utility of the vagina as an internal control. Overall, findings of the study corroborate with earlier studies and facilitate objective, noninvasive, and rapid Raman spectroscopic-based screening/diagnosis of cervical cancers.

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Fluorescence Spectroscopy for Evaluation of Safety Margins in Individuals With Surgically Treated Squamous Cell Carcinoma of the Oral Cavity

Cited by 2 publications

References 0 publications

Raman spectroscopy in cervical cancers: An update

Raman spectroscopy in cervical cancers: An update

In vivoRaman spectroscopy of human uterine cervix: exploring the utility of vagina as an internal control

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