Fluorescence Sensing of Circulating Diagnostic Biomarkers Using Molecular Probes and Nanoparticles

Tagit, Oya; Hildebrandt, Niko

doi:10.1021/acssensors.6b00625

Cited by 88 publications

(61 citation statements)

References 132 publications

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“…The fast moving field of lanthanide‐containing luminescent nanoparticles has been the subject of many recent reviews covering subjects as diverse as fundamental properties, synthesis, biosensing, bioimaging, drug delivery and theranostics, as well as persistent luminescence nanoparticles, NIR‐emitting nanoparticles, and forensic or other applications . The present review focuses on biological/medical applications and on lighting/displays, two main sectors in which nanomaterials have brought significant advances recently.…”

Section: Introductionmentioning

confidence: 99%

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Zhou

Leaño

Liu³

et al. 2018

Small

141

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Half a century after its initial emergence, lanthanide photonics is facing a profound remodeling induced by the upsurge of nanomaterials. Lanthanide-doped nanomaterials hold promise for bioapplications and photonic devices because they ally the unmatched advantages of lanthanide photophysical properties with those arising from large surface-to-volume ratios and quantum confinement that are typical of nanoobjects. Cutting-edge technologies and devices have recently arisen from this association and are in turn promoting nanophotonic materials as essential tools for a deeper understanding of biological mechanisms and related medical diagnosis and therapy, and as crucial building blocks for next-generation photonic devices. Here, the recent progress in the development of nanomaterials, nanotechnologies, and nanodevices for clinical uses and commercial exploitation is reviewed. The candidate nanomaterials with mature synthesis protocols and compelling optical uniqueness are surveyed. The specific fields that are directly driven by lanthanide doped nanomaterials are emphasized, spanning from in vivo imaging and theranostics, micro-/nanoscopic techniques, point-of-care medical testing, forensic fingerprints detection, to micro-LED devices.

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Section: Introductionmentioning

confidence: 99%

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Zhou

Leaño

Liu³

et al. 2018

Small

141

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“…Fluorescence labeling is a crucial tool to detect the fluorescence emitted from labeled molecules in analysis samples as a qualitative index [112–116]. Most fluorophores are small organic compounds with the conjugated unsaturated bond system.…”

Section: Bioanalytical Methods For Polyethylene Glycols and Pegylatedmentioning

confidence: 99%

Recent advances in the bioanalytical methods of polyethylene glycols and PEGylated pharmaceuticals

Zhang

Song

et al. 2020

J of Separation Science

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Polyethylene glycols are synthetic polymers composed of repeating oxyethylene subunits, which have been known for non-toxic, non-immunogenic, non-antigenic, good solubility in water and therefore approved for pharmaceutical applications. Recently, attachment or amalgamation of polyethylene glycols to therapeutic small molecules, peptides, proteins, or nanoparticles has become a mature technology for the sake of improving their pharmacokinetic and pharmacological profiles, also referred to as PEGylation. By comparison, there are only a few PEGylated pharmaceuticals have been registered for further clinical trials and even less was approved for marketing. High failure rate of PEGylated pharmaceuticals in pre-clinical and clinical trials could be majorly attributed to their unclear pharmacokinetic behaviors. Therefore, the in vivo fate of the PEGylated pharmaceuticals for the various routes of administration needs to be thoroughly investigated An accurate in vivo pharmacological study thereof highly depends on the precise detection of polyethylene glycols as well as their fragments in biological matrixes. The goal of this review is to highlight the analytical methods that were developed and applied to evaluate the polyethylene glycols in pharmaceutical ingredients and excipients, which bring us closer to bridging

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“…The use of quantum dots (QDs) has also proved popular in the construction of PSA sensors, especially in setups with other fluorophores by measuring of Förster resonance energy transfer (FRET) interactions [73]. QDs present many advantages beyond their tunable absorptions/emissions for the preparation of this kind of assays such as low LOD, multiplexing capability or ability to use body fluids without extensive sample treatment [74]. Quantum dots have been labelled with antibodies in sandwich immunoassays and although detection has been reported by mass spectrometry [75] or photoelectrochemically [76] the most widespread detection method is fluorescence or FRET so similar approaches have been applied to quantum dots involving aptamers and antibodies for fluorescent PSA detection.…”

Section: Psa Detection By Optical Methodsmentioning

confidence: 99%

Detection and monitoring prostate specific antigen using nanotechnology approaches to biosensing

Perry

Cortezon‐Tamarit

Pascu

2019

Front. Chem. Sci. Eng.

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Prostate cancer has a high incidence in men and remains the second cause of mortality due to cancer worldwide. As the development of the disease is greatly correlated to age, the identification of novel detection methods reliable, efficient, and cost effective is a matter of significant importance in the ageing population of western societies. The detection of the prostate specific antigen (PSA) in blood samples has been the preferred method for the detection and monitoring of prostate cancer over the past decades. Despite the indications against its use in massive population screening, PSA still remains the best studied biomarker for prostate cancer and the detection of its different forms and incorporation in multiplexed designs with other biomarkers still remains a highly valuable indicator in the theranostics of prostate cancer. The latest developments in the use of nanomaterials towards the construction of PSA biosensors are reviewed hereby. The incorporation of gold nanoparticles, silica nanoparticles and graphene nanostructures to biosensing devices has represented a big leap forward in terms of sensitivity, stability and miniaturization. Both electrochemical and optical detection methods for the detection of PSA will be reviewed herein.

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Fluorescence Sensing of Circulating Diagnostic Biomarkers Using Molecular Probes and Nanoparticles

Cited by 88 publications

References 132 publications

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Recent advances in the bioanalytical methods of polyethylene glycols and PEGylated pharmaceuticals

Detection and monitoring prostate specific antigen using nanotechnology approaches to biosensing

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