Fluorescence resonance energy transfer-based drug delivery systems for enhanced photodynamic therapy

Huang, Yu; Qiu, Feng; Chen, Rongjun; Yan, Deyue; Zhu, Xinyuan

doi:10.1039/d0tb00262c

Cited by 43 publications

(26 citation statements)

References 175 publications

(269 reference statements)

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“…Additionally, the three reviews of 2016 are remarkable in terms of depth of contents, including particular depth concerning PDT light sources [210,212,213]. They are focused on novel multifunctional nanoparticles, which can be classified into three major groups: near-infrared (NIR) light-excited nanomaterials [214][215][216], X-ray/Cherenkov excited scintillating/afterglow nanoparticles [217][218][219][220][221][222], and self-illuminated nanoconjugates [212,223]. Recently, implants have experienced rapid development, and several proofs of concepts with diverse modes of activation and light sources have been reported [224][225][226][227][228][229].…”

Section: Dosimetry and Sourcesmentioning

confidence: 99%

Photodynamic Therapy: A Compendium of Latest Reviews

Algorri

Ochoa

Roldán-Varona

et al. 2021

Cancers

163

130

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Photodynamic therapy (PDT) is a promising therapy against cancer. Even though it has been investigated for more than 100 years, scientific publications have grown exponentially in the last two decades. For this reason, we present a brief compendium of reviews of the last two decades classified under different topics, namely, overviews, reviews about specific cancers, and meta-analyses of photosensitisers, PDT mechanisms, dosimetry, and light sources. The key issues and main conclusions are summarized, including ways and means to improve therapy and outcomes. Due to the broad scope of this work and it being the first time that a compendium of the latest reviews has been performed for PDT, it may be of interest to a wide audience.

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Section: Dosimetry and Sourcesmentioning

confidence: 99%

Photodynamic Therapy: A Compendium of Latest Reviews

Algorri

Ochoa

Roldán-Varona

et al. 2021

Cancers

163

130

View full text Add to dashboard Cite

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“…The deeper light penetration is also pursued to a greater or lower extent following diverse approaches—namely, two-photon excitation [ 85 ], repeated PDT procedures [ 86 , 87 ], enhanced PS [ 88 ], a combination of PSs [ 89 ], X-rays, and internal bioluminescence [ 90 ]. The use of optical clearing agents is promising not only for deep-light delivery but also for characterisation and deep-monitoring [ 91 , 92 ].…”

Section: Light Technology For Pdtmentioning

confidence: 99%

Light Technology for Efficient and Effective Photodynamic Therapy: A Critical Review

Algorri

Ochoa

Roldán-Varona

et al. 2021

Cancers

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Photodynamic therapy (PDT) is a cancer treatment with strong potential over well-established standard therapies in certain cases. Non-ionising radiation, localisation, possible repeated treatments, and stimulation of immunological response are some of the main beneficial features of PDT. Despite the great potential, its application remains challenging. Limited light penetration depth, non-ideal photosensitisers, complex dosimetry, and complicated implementations in the clinic are some limiting factors hindering the extended use of PDT. To surpass actual technological paradigms, radically new sources, light-based devices, advanced photosensitisers, measurement devices, and innovative application strategies are under extensive investigation. The main aim of this review is to highlight the advantages/pitfalls, technical challenges and opportunities of PDT, with a focus on technologies for light activation of photosensitisers, such as light sources, delivery devices, and systems. In this vein, a broad overview of the current status of superficial, interstitial, and deep PDT modalities—and a critical review of light sources and their effects on the PDT process—are presented. Insight into the technical advancements and remaining challenges of optical sources and light devices is provided from a physical and bioengineering perspective.

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“…[9] Recently, emulsion-based approaches have also been extended to the surface functionalization of hydrophobic nanoparticles, in particular to lanthanide (Ln)-doped upconverting nano particles (UCNPs) of the general family MLnF 4 (M = alkali metal, such as Li, Na, K). [10][11][12][13] UCNPs are attractive materials due to the breadth of their potential applications ranging from imaging platforms [14,15] and energy donors in Förster resonance energy transfer (FRET) pairs [16][17][18][19] to light-triggered therapies, [11,13,20,21] among others. [22][23][24] However, synthesis of high-quality UCNPs is most commonly performed in a hydrophobic environment, generating samples that are not water-dispersible.…”

Section: Introductionmentioning

confidence: 99%

Phytoglycogen Encapsulation of Lanthanide‐Based Nanoparticles as an Optical Imaging Platform with Therapeutic Potential

Rodrigues

Calvert

Crawford

et al. 2022

Small

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Lanthanide‐based upconverting nanoparticles (UCNPs) are largely sought‐after for biomedical applications ranging from bioimaging to therapy. A straightforward strategy is proposed here using the naturally sourced polymer phytoglycogen to coencapsulate UCNPs with hydrophobic photosensitizers as an optical imaging platform and light‐induced therapeutic agents. The resulting multifunctional sub‐micrometer‐sized luminescent beads are shown to be cytocompatible as carrier materials, which encourages the assessment of their potential in biomedical applications. The loading of UCNPs of various elemental compositions enables multicolor hyperspectral imaging of the UCNP‐loaded beads, endowing these materials with the potential to serve as luminescent tags for multiplexed imaging or simultaneous detection of different moieties under near‐infrared (NIR) excitation. Coencapsulation of UCNPs and Rose Bengal opens the door for potential application of these microcarriers for collagen crosslinking. Alternatively, coloading UCNPs with Chlorin e6 enables NIR‐light triggered generation of reactive oxygen species. Overall, the developed encapsulation methodology offers a straightforward and noncytotoxic strategy yielding water‐dispersible UCNPs while preserving their bright and color‐tunable upconversion emission that would allow them to fulfill their potential as multifunctional platforms for biomedical applications.

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Fluorescence resonance energy transfer-based drug delivery systems for enhanced photodynamic therapy

Abstract: In this Review, recent advances in fluorescence resonance energy transfer-based drug delivery systems for enhanced photodynamic therapy are described, and the current challenges and perspectives in this emerging field are also discussed.

Cited by 43 publications

References 175 publications

Photodynamic Therapy: A Compendium of Latest Reviews

Photodynamic Therapy: A Compendium of Latest Reviews

Light Technology for Efficient and Effective Photodynamic Therapy: A Critical Review

Phytoglycogen Encapsulation of Lanthanide‐Based Nanoparticles as an Optical Imaging Platform with Therapeutic Potential

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