Fluorescence optical imaging: ready for prime time?

Ohrndorf, Sarah; Glimm, Anne-Marie; Ammitzbøll-Danielsen, Mads; Østergaard, Mikkel; Burmester, G. R.

doi:10.1136/rmdopen-2020-001497

Cited by 16 publications

(44 citation statements)

References 32 publications

(59 reference statements)

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“…The examination of both hands lasts 6 min and one image per second is recorded, resulting in a total of 360 images. A recently published comprehensive review summarized the role of FOI in research and clinical practice and outlined how FOI can complement our current imaging repertoire in rheumatology [ 87 ]. While some studies have compared FOI to MRI and MSUS in patients with RA and demonstrated that it is a useful technique and can be used to distinguish RA from osteoarthritis, as of yet, there are no published studies on the use of FOI in SLE [ 87 ].…”

Section: Resultsmentioning

confidence: 99%

“…A recently published comprehensive review summarized the role of FOI in research and clinical practice and outlined how FOI can complement our current imaging repertoire in rheumatology [ 87 ]. While some studies have compared FOI to MRI and MSUS in patients with RA and demonstrated that it is a useful technique and can be used to distinguish RA from osteoarthritis, as of yet, there are no published studies on the use of FOI in SLE [ 87 ]. However, initial data comparing FOI and MSUS images of the hands of a patient with ‘Rhupus’ suggest that FOI may be a useful technique for detecting joint manifestations in patients with ‘Rhupus’ and possibly SLE (Fig.…”

Section: Resultsmentioning

confidence: 99%

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A Narrative Literature Review Comparing the Key Features of Musculoskeletal Involvement in Rheumatoid Arthritis and Systemic Lupus Erythematosus

et al. 2022

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Although the clinical approach to the management of musculoskeletal manifestations in systemic lupus erythematosus (SLE) is often similar to that of rheumatoid arthritis (RA), there are distinct differences in immunopathogenesis, structural and imaging phenotypes and therapeutic evidence. Additionally, there are few published comparisons of these diseases. The objective of this narrative literature review is to compare the immunopathogenesis, structural features, magnetic resonance imaging (MRI) and musculoskeletal ultrasound (MSUS) studies and management of joint manifestations in RA and SLE. We highlight the key similarities and differences between the two diseases. Overall, the literature evaluated indicates that synovitis and radiographical progression are the key features in RA, while inflammation without swelling, tendinitis and tenosynovitis are more prominent features in SLE. In addition, the importance of defining patients with RA by the presence or absence of autoantibodies and categorizing patients with SLE by synovitis detected by musculoskeletal ultrasound and by structural phenotype (non-deforming, non-erosive arthritis, Jaccoud’s arthropathy and ‘Rhupus’) with respect to joint manifestations will also be discussed. An increased understanding of the joint manifestations in RA and SLE may inform evidence-based clinical decisions for both diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A Narrative Literature Review Comparing the Key Features of Musculoskeletal Involvement in Rheumatoid Arthritis and Systemic Lupus Erythematosus

et al. 2022

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“…Since MRI can visualize and localize inflammation without the need for radionuclide injection and ionizing radiation exposure, the scope of PET/CT will likely not extend beyond specific research applications 91 . As a comparatively new technique in this field, FOI requires further investigation to demonstrate its value 92 …”

Section: Discussionmentioning

confidence: 99%

“…91 As a comparatively new technique in this field, FOI requires further investigation to demonstrate its value. 92 As the aim of this study was to scope for features and provide a terminology for further investigation, additional studies are needed to determine the clinical utility of the glossary. The notable inter-and intra-method discrepancies of microvascular changes, in particular regarding 9 capillaroscopic features, warrant a critical reassessment before psoriatic activity can be quantified reliably using capillary metrics.…”

Section: Clinical Relevance Of Non-invasive Imagingmentioning

confidence: 99%

Imaging of the nail unit in psoriatic patients:A systematic scoping review of techniques and terminology

Ortner

Mandel

Bertugno

et al. 2022

Experimental Dermatology

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Background The growing interest in the visualization of psoriatic nail unit changes has led to the discovery of an abundance of image characteristics across various modalities. Objective To identify techniques for non‐invasive imaging of nail unit structures in psoriatic patients and review extracted image features to unify the diverse terminology. Methods For this systematic scoping review, we included studies available on PubMed and Embase, independently extracted image characteristics, and semantically grouped the identified features to suggest a preferred terminology for each technique. Results After screening 753 studies, 67 articles on the visualization of clinical and subclinical psoriatic changes in the nail plate, matrix, bed, folds and hyponychium were included. We identified 4 optical and 3 radiological imaging techniques for the assessment of surface (dermoscopy [n = 16], capillaroscopy [n = 12]), sub‐surface (ultrasound imaging [n = 36], optical coherence tomography [n = 4], fluorescence optical imaging [n = 3]), and deep‐seated psoriatic changes (magnetic resonance imaging [n = 2], positron emission tomography‐computed tomography [n = 1]). By condensing 244 image feature descriptions into a glossary of 82 terms, overall redundancy was cut by 66.4% (37.5%–77.1%). More than 75% of these image features provide additional disease‐relevant information that is not captured using conventional clinical assessment scales. Conclusions This review has identified, unified, and contextualized image features and related terminology for non‐invasive imaging of the nail unit in patients with psoriatic conditions. The suggested glossary could facilitate the integrative use of non‐invasive imaging techniques for the detailed examination of psoriatic nail unit structures in research and clinical practice.

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“…PsA is a seronegative arthritis with late pathognomonic signs in conventional radiology. Newly developed imaging techniques may be more sensitive for the early diagnosis of PsA [7]. However, to a certain degree, the diagnosis of PsA depends on the presence of diseased skin or nail manifestations on the patient or in the family history, as proposed by the classification criteria for PsA (CASPAR) [8].…”

Section: Introductionmentioning

confidence: 99%

The Effect of TNF-α Inhibitors on Nail Psoriasis and Psoriatic Arthritis—Real-World Data from Dermatology Practice

Kokolakis

Sabat

Fischer

et al. 2021

JPM

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Patients with psoriatic arthritis (PsA) often develop joint symptoms years after their initial diagnosis of psoriasis disease; therefore, dermatologists should test for and detect PsA early. In this study, we focused on patients with psoriasis with both nail and joint disease being treated with tumor necrosis factor-α inhibitors by dermatologists. We performed a noninterventional, prospective, multicenter, and open-label study to evaluate the effectiveness of adalimumab, etanercept, or infliximab over 24 months of continuous therapy in patients with moderate to severe plaque-type psoriasis (Pso) and PsA. Disease assessments with the Psoriasis Area and Severity Index, Nail Psoriasis Severity Index (NAPSI), joint assessment, Dermatology Life Quality Index (DLQI), and Health Assessment Questionnaire (HAQ) instruments were performed every 3 months for the first year and twice annually thereafter. The cohort included 100 patients with Pso, nail psoriasis, and PsA. A significant reduction of NAPSI was observed 3 months after therapy initiation compared with the baseline (mean ± SD, 22.9 ± 17.8 vs. 33.8 ± 21.4; p < 0.001). Similarly, the mean ± SD number of both tender and swollen joints decreased significantly within the first 3 months of treatment, from 10.8 ± 11.5 to 6.4 ± 10.3 (p < 0.001) and from 6.4 ± 9.5 to 3.1 ± 7.2 (p < 0.001), respectively. Additionally, the distal interphalangeal joint involvement improved throughout the observation time, and DLQI and HAQ scores decreased. Improvements in control of skin, nail, and joint symptoms were seen, as well as in patients’ quality of life and functionality. Dermatologists have an important role not only in PsA diagnosis but also in PsA long-term care.

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Fluorescence optical imaging: ready for prime time?

Cited by 16 publications

References 32 publications

A Narrative Literature Review Comparing the Key Features of Musculoskeletal Involvement in Rheumatoid Arthritis and Systemic Lupus Erythematosus

A Narrative Literature Review Comparing the Key Features of Musculoskeletal Involvement in Rheumatoid Arthritis and Systemic Lupus Erythematosus

Imaging of the nail unit in psoriatic patients:A systematic scoping review of techniques and terminology

The Effect of TNF-α Inhibitors on Nail Psoriasis and Psoriatic Arthritis—Real-World Data from Dermatology Practice

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