Fluorescence optical imaging for treatment monitoring in patients with early and active rheumatoid arthritis in a 1-year follow-up period

Glimm, Anne-Marie; Sprenger, Lisa Ines; Haugen, I.K.; Mansmann, Ulrich; Hermann, Sandra; Häupl, Thomas; Hoff, Paula; Burmester, Gerd‐Rüdiger; Backhaus, Marina; Le, Long Khanh‐Dao; Ohrndorf, Sarah

doi:10.1186/s13075-019-1989-5

Cited by 17 publications

(18 citation statements)

References 37 publications

(53 reference statements)

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“…FOI has been used for various questions and diseases in rheumatology. For example, investigation was performed in the detection of inflamed joints in RA [ 28 , 30 , 39 – 41 ]. Following studies concentrated on the examination of OA with different inflammatory patterns [ 36 ] or decreased blood flow in systemic sclerosis [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…Werner et al and Fischer et al showed that FOI correlates well with clinical examination, MRI, or ultrasound findings in patients with arthritis [28,29]. Furthermore, it has been shown that FOI is able to visualize changes in joint inflammation during anti-rheumatic therapy [30,31] and that it can even detect subclinical synovitis in patients with inflammatory arthritis [32]. It was not only used in diagnostics and monitoring of RA and other arthritic diseases, but also for the detection of a disturbed microcirculation and prediction of digital ulcers in systemic sclerosis (SSc) [33,34].…”

Section: Introductionmentioning

confidence: 97%

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Detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging

et al. 2020

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Objectives: To investigate the frequency of subclinical skin inflammation in both hands by fluorescence optical imaging (FOI) in patients with psoriasis/psoriatic arthritis (Pso/PsA) vs. rheumatoid arthritis (RA) and healthy individuals, and to correlate these findings with cardiovascular (CV) risk factors. Patients and methods: The FOI scans were analyzed retrospectively to detect clinically invisible skin enhancement (0-3 scale) in both hands without relationship to underlying joints or blood vessels. We further characterized the FOI patterns and sorted the scans into groups based on the assumed diagnosis (Pso/PsA, RA, and healthy controls), which was compared with the physician's diagnosis. Furthermore, the associations between CV risk factors and imaging findings were investigated by regression analyses. Results: We included FOI scans of patients with Pso/PsA (n = 80), RA (n = 78), and healthy controls (n = 25). Subclinical skin enhancement on the back of their hands was more common in Pso/PsA (72.5%) than in RA patients (20.5%) and healthy individuals (28.0%) (p < 0.001). Based on the FOI pattern, the majority of patients with Pso/PsA (72.5%), RA (76.9%), and healthy controls (68.0%) were classified correctly using the physician-based diagnosis as reference (overall agreement of 74%, kappa = 0.57). No CV risk factors except body weight (kg) were associated with subclinical skin enhancement (OR 1.04, 95% CI 1.02-1.06; p < 0.001). Conclusion: Subclinical subdermal skin inflammation was common in Pso/PsA patients using FOI. Based on the FOI pattern, most patients with Pso/PsA and were classified with the correct diagnosis. We demonstrated an important influence of the body weight on our FOI results. FOI may be a helpful novel tool to study microcirculation in rheumatic diseases with skin involvement.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging

et al. 2020

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“…Werner et al and Fischer et al showed that FOI correlates well with clinical examination, MRI or ultrasound ndings in patients with arthritis. (28,29) Furthermore, it has been shown that FOI is able to visualize changes in joint in ammation during anti-rheumatic therapy (30,31) and that it can even detect subclinical synovitis in patients with in ammatory arthritis. (32) It was not only used in diagnostics and monitoring of RA and other arthritic diseases, but also for detection of a disturbed microcirculation and prediction of digital ulcers in systemic sclerosis (SSc).…”

Section: Introductionmentioning

confidence: 99%

Detection of Subclinical Skin Manifestation in Patients With Psoriasis and Psoriatic Arthritis by Fluorescence Optical Imaging

Schmidt

Glimm

Haugen

et al. 2020

Preprint

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Objectives:To investigate the frequency of subclinical skin inflammation in both hands by fluorescence optical imaging (FOI) in patients with psoriasis/psoriatic arthritis (Pso/PsA) vs. rheumatoid arthritis (RA) and healthy individuals, and to correlate these findings with cardiovascular (CV) risk factors.Patients and Methods:The FOI scans were analyzed retrospectively to detect clinically invisible skin enhancement (0-3 scale) in both hands without relationship to underlying joints or blood vessels. We further characterized the FOI patterns and sorted the scans into groups based on the assumed diagnosis (Pso/PsA, RA and healthy controls), which was compared with the physician’s diagnosis. Furthermore, the associations between CV risk factors and imaging findings were investigated by regression analyses.Results:We included FOI scans of patients with Pso/PsA (n=80), RA (n=78) and healthy controls (n=25). Subclinical skin enhancement on the back of their hands was more common in Pso/PsA (72.5%) than in RA patients (20.5%) and healthy individuals (28.0%) (p<0.001). Based on the FOI pattern, the majority of patients with Pso/PsA (72.5%), RA (76.9%) and healthy controls (68.0%) were classified correctly using the physician-based diagnosis as reference (overall agreement of 74%, kappa=0.57). No CV risk factors except body weight (kg) was associated with subclinical skin enhancement (OR 1.04, 95% CI 1.02-1.06; p<0.001).Conclusion:Subclinical subdermal skin inflammation was common in Pso/PsA patients using FOI. Based on the FOI pattern, most patients with Pso/PsA and were classified with the correct diagnosis. We demonstrated an important influence of the body weight on our FOI results. FOI may be a helpful novel tool to study microcirculation in rheumatic diseases with skin involvement.

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“…For example, investigation was performed in the detection of in amed joints in RA. (28,30,(39)(40)(41) Following studies concentrated on the examination of OA with different in ammatory patterns (36) or decreased blood ow in systemic sclerosis. (33,34) To our knowledge, we are the rst group to investigate potential subclinical in ammation of the skin in Pso/PsA patients.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging

Schmidt

Glimm

Haugen

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Objectives: To investigate the frequency of subclinical skin inflammation in both hands by fluorescence optical imaging (FOI) in patients with psoriasis/psoriatic arthritis (Pso/PsA) vs. rheumatoid arthritis (RA) and healthy individuals, and to correlate these findings with cardiovascular (CV) risk factors.Patients and Methods: The FOI scans were analyzed retrospectively to detect clinically invisible skin enhancement (0-3 scale) in both hands without relationship to underlying joints or blood vessels. We further characterized the FOI patterns and sorted the scans into groups based on the assumed diagnosis (Pso/PsA, RA and healthy controls), which was compared with the physician’s diagnosis. Furthermore, the associations between CV risk factors and imaging findings were investigated by regression analyses.Results: We included FOI scans of patients with Pso/PsA (n=80), RA (n=78) and healthy controls (n=25). Subclinical skin enhancement on the back of their hands was more common in Pso/PsA (72.5%) than in RA patients (20.5%) and healthy individuals (28.0%) (p<0.001). Based on the FOI pattern, the majority of patients with Pso/PsA (72.5%), RA (76.9%) and healthy controls (68.0%) were classified correctly using the physician-based diagnosis as reference (overall agreement of 74%, kappa=0.57). No CV risk factors except body weight (kg) was associated with subclinical skin enhancement (OR 1.04, 95% CI 1.02-1.06; p<0.001). Conclusion: Subclinical subdermal skin inflammation was common in Pso/PsA patients using FOI. Based on the FOI pattern, most patients with Pso/PsA and were classified with the correct diagnosis. We demonstrated an important influence of the body weight on our FOI results. FOI may be a helpful novel tool to study microcirculation in rheumatic diseases with skin involvement.

show abstract

Fluorescence optical imaging for treatment monitoring in patients with early and active rheumatoid arthritis in a 1-year follow-up period

Cited by 17 publications

References 37 publications

Detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging

Detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging

Detection of Subclinical Skin Manifestation in Patients With Psoriasis and Psoriatic Arthritis by Fluorescence Optical Imaging

Detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging

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