Fluorescence of testicle

Growth inhibition and induction of phenotypic alterations in MCF-7 breast cancer cells by an IMP dehydrogenase inhibitor

“…The activity of IMP dehydrogenase was shown to be markedly increased in transformed cells (Weber, 1977). Inhibitors of IMP dehydrogenase were found to be cytotoxic towards several tumour lines including those unresponsive to other chemotherapeutic agents (Sweeney et al, 1972;Carney et al, 1985;Connoly & Halsall, 1975). IMP dehydrogenase inhibitors have recently been shown to induce cell differentiation in the promyelocytic cell line HL-60 (Lucas et al, 1983;Wright, 1987).…”