Fluorescence Lifetime Imaging Ophthalmoscopy as Predictor of Long-Term Functional Outcome in Macula-Off Rhegmatogenous Retinal Detachment

Jaggi, Damian; Solberg, Yasmin; Dysli, Chantal; Lincke, Joel; Habra, Oussama; Wolf, Sebastián; Zinkernagel, Martin

doi:10.1097/iae.0000000000003612

Cited by 2 publications

(2 citation statements)

References 29 publications

(66 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MP analysis with digital filters represents another biomarker that can be measured intraoperatively, potentially serving as a predictive factor for postoperative outcome in macular diseases. Jaggi et al recently demonstrated that postoperative MP fluorescence was predictive of long-term postoperative outcome in cases of retinal detachment [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Operative Digital Enhancement of Macular Pigment during Macular Surgery

Sandali

Hassani

Balamoun³

et al. 2023

JCM

View full text Add to dashboard Cite

Purpose: To describe the feasibility of intraoperative digital visualization and its contribution to the enhancement of macular pigmentation visualization in a prospective series of macular surgery interventions. Materials and Methods: A prospective, single-center, single-surgeon study was performed on a series of 21 consecutive cases of vitrectomy for various types of macular surgery using a 3D visualization system. Two optimized filters were applied to enhance the visualization of the macular pigment (MP). For filter 1, cyan, yellow, and magenta color saturations were increased. Filter 2 differed from filter 1 only in having a lower level of magenta saturation for the green-magenta color channel. Results: Optimized digital filters enhanced the visualization of the MP and the pigmented epiretinal tissue associated with the lamellar and macular holes. In vitreomacular traction surgery, the filters facilitated the assessment of MP integrity at the end of surgery. Filter 1 enhanced MP visualization most strongly, with the MP appearing green and slightly fluorescent. Filter 2 enhanced MP visualization less effectively but gave a clearer image of the retinal surface, facilitating safe macular peeling. Conclusion: Optimized digital filters could be used to enhance MP and pigmented epiretinal tissue visualization during macular surgery. These filters open new horizons for future research and should be evaluated in larger series and correlated with intraoperative OCT.

show abstract

Section: Discussionmentioning

confidence: 99%

Operative Digital Enhancement of Macular Pigment during Macular Surgery

Sandali

Hassani

Balamoun³

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

“…Clinical fluorescence lifetime ophthalmoscopy (FLIO; Heidelberg Spectralis, Heidelberg, Germany) measures FL simultaneously with FAF over the central 30 degrees of the retina. Clinical FLIO has shown changes in clinically normal retina 11 and many retinal diseases 12 , 13 including AMD. 11 , 14 Adaptive optics fluorescence lifetime ophthalmoscopy (AOFLIO) provides finer axial resolution (approximately 40 microns) than standard clinical FLIO techniques.…”

mentioning

confidence: 99%

Fluorescence Lifetime Imaging of Human Retinal Pigment Epithelium in Pentosan Polysulfate Toxicity Using Adaptive Optics Scanning Light Ophthalmoscopy

Bowles Johnson,

Tang,

Kunala

et al. 2024

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Purpose Fluorescence lifetime ophthalmoscopy (FLIO) is an emerging clinical modality that could provide biomarkers of retinal health beyond fluorescence intensity. Adaptive optics (AO) ophthalmoscopy provides the confocality to measure fluorescence lifetime (FL) primarily from the retinal pigment epithelium (RPE) whereas clinical FLIO has greater influence from fluorophores in the inner retina and lens. Adaptive optics fluorescence lifetime ophthalmoscopy (AOFLIO) measures of FL in vivo could provide insight into RPE health at different stages of disease. In this study, we assess changes in pentosan polysulfate sodium (PPS) toxicity, a recently described toxicity that has clinical findings similar to advanced age-related macular degeneration. Methods AOFLIO was performed on three subjects with PPS toxicity (57–67 years old) and six age-matched controls (50-64 years old). FL was analyzed with a double exponential decay curve fit and with phasor analysis. Regions of interest (ROIs) were subcategorized based on retinal features on optical coherence tomography (OCT) and compared to age-matched controls. Results Twelve ROIs from PPS toxicity subjects met the threshold for analysis by curve fitting and 15 ROIs met the threshold for phasor analysis. Subjects with PPS toxicity had prolonged FL compared to age-matched controls. ROIs of RPE degeneration had the longest FLs, with individual pixels extending longer than 900 ps. Conclusions Our study shows evidence that AOFLIO can provide meaningful information in outer retinal disease beyond what is obtainable from fluorescence intensity alone. More studies are needed to determine the prognostic value of AOFLIO.

show abstract

Fluorescence Lifetime Imaging Ophthalmoscopy as Predictor of Long-Term Functional Outcome in Macula-Off Rhegmatogenous Retinal Detachment

Abstract: Macular fluorescence lifetimes 1 month after the surgery for macula-off rhegmatogenous retinal detachment correlate significantly with long-term functional outcomes at 6 months after the surgery

Cited by 2 publications

References 29 publications

Operative Digital Enhancement of Macular Pigment during Macular Surgery

Operative Digital Enhancement of Macular Pigment during Macular Surgery

Fluorescence Lifetime Imaging of Human Retinal Pigment Epithelium in Pentosan Polysulfate Toxicity Using Adaptive Optics Scanning Light Ophthalmoscopy

Contact Info

Product

Resources

About