Fluorescence <i>in‐situ</i> hybridization identifies Mastermind‐like 2 (<i>MAML2)</i> rearrangement in odontogenic cysts with mucous prosoplasia: a pilot study

Argyris, Prokopios P.; Wehrs, Rebecca N.; García, Joaquín J.; Koutlas, Ioannis G.

doi:10.1111/his.12526

Cited by 21 publications

(24 citation statements)

References 31 publications

(74 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To our knowledge, such salivary gland tumors have not been studied for MAML2 gene rearrangements. Furthermore, it should be noted that MAML2 rearrangements have been identified in other odontogenic cysts besides GOC, including dentigerous and radicular cysts . These findings demonstrate the limitations of molecular analysis for MAML2 rearrangements in such cystic lesions, despite its potential diagnostic value.…”

Section: Discussionmentioning

confidence: 83%

Assessment of biologically aggressive, recurrent glandular odontogenic cysts for mastermind‐like 2 (MAML2) rearrangements: histopathologic and fluorescent in situ hybridization (FISH) findings in 11 cases

Greer

Eskendri

Freedman

et al. 2017

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 83%

Assessment of biologically aggressive, recurrent glandular odontogenic cysts for mastermind‐like 2 (MAML2) rearrangements: histopathologic and fluorescent in situ hybridization (FISH) findings in 11 cases

Greer

Eskendri

Freedman

et al. 2017

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…In their opinion, this finding lends credence to discredit the putative nature of a glandular odontogenic cyst as a precursor to central mucoepidermoid carcinoma . A very recent study from Mayo demonstrated the presence of MAML2 rearrangements in a small subset of odontogenic cysts with mucous prosoplasia . The fusion transcript has been reported to be present in a limited group of tumors, including mucoepidermoid carcinomas at various sites (bronchiole, cervix, and breast), some Warthin tumors, and clear cell hidradenoma of the skin, but not in other types of malignancies .…”

Section: Discussionmentioning

confidence: 91%

Primary intraosseous mucoepidermoid carcinoma of the jaw: Reappraisal of The MD Anderson Cancer Center experience

et al. 2015

View full text Add to dashboard Cite

Intraosseous mucoepidermoid carcinoma diagnosis should be based on clinical and pathologic manifestations and complete resection is the first choice for patient treatment. The need for neck dissection and adjuvant treatment are debatable. Radiotherapy may improve prognosis and may be recommended in the postoperative period. Primary intraosseous mucoepidermoid carcinoma can manifest the fusion transcript in a subset of tumors. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1312-E1317, 2016.

show abstract

“…However, it must be remembered that absence of this mutation does not exclude a diagnosis of MC; although it is detectable in 80% of low‐grade MC, it is only present in 46% of high‐grade MC. The results of a pilot study of MAML2 rearrangements in odontogenic cysts recently published by Argyris et al . also raise the possibility that the mutation is not specific for MC; five cysts (four dentigerous, one radicular) demonstrated the MAML2 rearrangement of the nine in which hybridisation was successful; it failed in the one GOC included in the study.…”

Section: Discussionmentioning

confidence: 99%

Molecular diagnostics in the differential diagnosis of glandular odontogenic cyst and mucoepidermoid carcinoma – case reports

et al. 2015

View full text Add to dashboard Cite

Glandular odontogenic cyst (sialo-odontogenic cyst) (GOC) is an uncommon developmental odontogenic cyst. Its clinical significance lies in its tendency to recur, and histopathological features which mimic those of mucoepidermoid carcinoma (MC). Molecular methods such as fluorescence in situ hybridisation (FISH) have the potential to identify genetic abnormalities that are specific to MC and thus avoid this diagnostic pitfall. This report describes three cystic lesions of the jaws with a differential diagnosis of GOC and MC. One occurred in the mandibular premolar area of a 49-year-old woman and was diagnosed as GOC. The second developed in the maxilla of a man aged 39 in association with an impacted second premolar tooth. This was initially diagnosed as dentigerous cyst, but after recurrence 6 years later, the diagnosis was revised to GOC. The third occurred in the left retromolar area of a 30-year-old woman 5 years after the extraction of the left mandibular third molar; a diagnosis of GOC was favoured after two incisional biopsies, but a third showed unequivocal, invasive MC which had infiltrated nerves and bone. Morphologically, the only distinguishing feature was the so-called epithelial sphere, whorl or plaque-like thickening, which was identified in both GOC but not in the MC. FISH confirmed the above diagnoses by demonstrating a MAML2 rearrangement in the MC, but in neither of the GOC. While histopathology may reliably distinguish between GOC and MC, the presence of the specific MAML2 rearrangement in the latter clinches the diagnosis. Clinical relevance Scientific rationale for studyTo highlight the diagnostic difficulties posed by two glandular odontogenic cysts (GOC) and a mucoepidermoid carcinoma (MC). Although benign, GOC has a tendency to recur. MC is unequivocally malignant. The two entities may be difficult to distinguish by histopathological features. However, some MC have a specific gene (MAML2) rearrangement which can be identified by molecular methods. Principal findingsThe MC was positive for the MAML2 gene rearrangement; the two GOC were negative.

show abstract

Fluorescence in‐situ hybridization identifies Mastermind‐like 2 (MAML2) rearrangement in odontogenic cysts with mucous prosoplasia: a pilot study

Abstract: We identified MAML2 rearrangements in five of nine ODCs lined by mucus-secreting cells. This suggests that at least a subset of ODCs with mucous prosoplasia are characterized by molecular events considered diagnostic for intraosseous and extraosseous MEC.

Cited by 21 publications

References 31 publications

Assessment of biologically aggressive, recurrent glandular odontogenic cysts for mastermind‐like 2 (MAML2) rearrangements: histopathologic and fluorescent in situ hybridization (FISH) findings in 11 cases

Assessment of biologically aggressive, recurrent glandular odontogenic cysts for mastermind‐like 2 (MAML2) rearrangements: histopathologic and fluorescent in situ hybridization (FISH) findings in 11 cases

Primary intraosseous mucoepidermoid carcinoma of the jaw: Reappraisal of The MD Anderson Cancer Center experience

Molecular diagnostics in the differential diagnosis of glandular odontogenic cyst and mucoepidermoid carcinoma – case reports

Contact Info

Product

Resources

About