Fluorescence guided surgery to improve peritoneal cytoreduction in epithelial ovarian cancer: A systematic review of available data

Boussedra, Safia; Benoit, Louise; Koual, Meriem; Bentivegna, Enrica; Nguyen-Xuan, Huyên-Thu; Bats, Anne‐Sophie; Azaïs, Henri

doi:10.1016/j.ejso.2022.02.022

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…Although EOC‐targeted fluorescent probes in clinical trials were considered safe, their efficiency evaluation was not standardised because of the heterogeneity of the studies. 79 Furthermore, similar limitations were observed when we evaluated the preclinical EOC‐targeted fluorescent probes. Therefore, the theory that changes in surgical decisions are the most objective parameter was adopted in our evaluation.…”

Section: Discussionsupporting

confidence: 53%

“…Type‐III fluorescent probes hold great potential owing to their excellent optical characteristics; however, their recognition groups limit their broader clinical application. Although EOC‐targeted fluorescent probes in clinical trials were considered safe, their efficiency evaluation was not standardised because of the heterogeneity of the studies 79 . Furthermore, similar limitations were observed when we evaluated the preclinical EOC‐targeted fluorescent probes.…”

Section: Discussionmentioning

confidence: 94%

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Updates on fluorescent probes and open‐field imaging methods for fluorescence‐guided cytoreductive surgery for epithelial ovarian cancer: A review

Sun

Huang

Jiang

et al. 2022

BJOG

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Fluorescence‐guided surgery has emerged as a promising imaging technique for real‐time intraoperative tumour delineation and visualisation of submillimetre tumour masses in cytoreductive surgery for epithelial ovarian cancer (EOC). Researchers have developed several EOC‐targeted fluorescent probes, most of which are currently in the preclinical stage. Interestingly, imaging devices designed for open surgery are proof of concept. This review summarises the recent advances in EOC‐targeted fluorescent probes and open‐field fluorescence imaging strategies and discusses the challenges and potential solutions for clinical translation.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 94%

Updates on fluorescent probes and open‐field imaging methods for fluorescence‐guided cytoreductive surgery for epithelial ovarian cancer: A review

Sun

Huang

Jiang

et al. 2022

BJOG

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“…Furthermore, the development of image-guided surgical tools might integrate the AI application. In fact, while they have already been investigated to guide lymphadenectomy during resective surgery [98], the use of tools such as fluorescence could also help to detect microscopic peritoneal metastasis, similar to what has already been reported for ovarian cancer [99]. However, the evidence in the current literature is still anecdotal, and AI has not yet been employed in routine clinical practice on large datasets.…”

Section: Will There Still Be Room For Sl In the Era Of Artificial Int...mentioning

confidence: 83%

The Role of Staging Laparoscopy for Gastric Cancer Patients: Current Evidence and Future Perspectives

Schena

Laterza

Sio

et al. 2023

Cancers

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A significant proportion of patients diagnosed with gastric cancer is discovered with peritoneal metastases at laparotomy. Despite the continuous improvement in the performance of radiological imaging, the preoperative recognition of such an advanced disease is still challenging during the diagnostic work-up, since the sensitivity of CT scans to peritoneal carcinomatosis is not always adequate. Staging laparoscopy offers the chance to significantly increase the rate of promptly diagnosed peritoneal metastases, thus reducing the number of unnecessary laparotomies and modifying the initial treatment strategy of gastric cancer. The aim of this review was to provide a comprehensive summary of the current literature regarding the role of staging laparoscopy in the management of gastric cancer. Indications, techniques, accuracy, advantages, and limitations of staging laparoscopy and peritoneal cytology were discussed. Furthermore, a focus on current evidence regarding the application of artificial intelligence and image-guided surgery in staging laparoscopy was included in order to provide a picture of the future perspectives of this technique and its integration with modern tools in the preoperative management of gastric cancer.

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“…Although fluorescence-guided surgery has been used for other tumors, clinical research invariably lacks sufficient data on long-term clinical and oncologic outcomes 47 48. However, most available data are based on gastrointestinal and urological tumors not ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

Can fluorescence-guided surgery improve optimal surgical treatment for ovarian cancer? A systematic scoping review of clinical studies

El-Swaify

Laban

Ali

et al. 2023

Int J Gynecol Cancer

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BackgroundThe predicament of achieving optimal surgical intervention faced by surgeons in treating ovarian cancer has driven research into improving intra-operative detection of cancer using fluorescent materials.ObjectiveTo provide a literature overview on the clinical use of intra-operative fluorescence-guided surgery for ovarian cancer, either for cytoreductive surgery or sentinel lymph node (SLN) biopsy.MethodsThe systematic review included studies from June 2002 until October 2021 from PubMed, Web of Science, and Scopus as well as those from a search of related literature. Studies were included if they investigated the use of fluorescence-guided surgery in patients with a diagnosis of ovarian cancer. Authors charted variables related to study characteristics, patient demographics, baseline clinical characteristics, fluorescence-guided surgery material, and treatment details, and surgical, oncological, and survival outcome variables. After screening 2817 potential studies, 24 studies were included.ResultsStudies investigating the role of fluorescence-guided surgery to visualize tumor deposits or SLN biopsy included the data of 410 and 118 patients, respectively. Six studies used indocyanine green tracer with a mean SLN detection rate of 92.3% with a pelvic and para-aortic detection rate of 94.8% and 96.7%, respectively. The sensitivity, specificity, and positive predictive value for micrometastases detection of OTL38 and 5-aminolevulinc acid at time of cytoreduction were 92.2% vs 79.8%, 67.3% vs 94.8%, and 55.8% vs 95.8%, respectively.ConclusionFluorescence -guided surgery is a technique that may improve the detection rate of micrometastases and SLN identification in ovarian cancer. Further research is needed to establish whether this will lead to improved patient outcomes.

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Fluorescence guided surgery to improve peritoneal cytoreduction in epithelial ovarian cancer: A systematic review of available data

Cited by 6 publications

References 34 publications

Updates on fluorescent probes and open‐field imaging methods for fluorescence‐guided cytoreductive surgery for epithelial ovarian cancer: A review

Updates on fluorescent probes and open‐field imaging methods for fluorescence‐guided cytoreductive surgery for epithelial ovarian cancer: A review

The Role of Staging Laparoscopy for Gastric Cancer Patients: Current Evidence and Future Perspectives

Can fluorescence-guided surgery improve optimal surgical treatment for ovarian cancer? A systematic scoping review of clinical studies

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