Fluorescence‐guided surgery for liver tumors

Nakaseko, Yuichi; Ishizawa, Takeaki; Saiura, Akio

doi:10.1002/jso.25128

Cited by 105 publications

(74 citation statements)

References 40 publications

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“…Fluorescence-guided surgery is an innovative technology that holds considerable promise in the field of HCC. 35 ICG, a vital dye that is widely used to assess liver function, binds to plasma proteins and emits light with a peak wavelength of around 830 nm when illuminated with near-infrared (NIR) light. ICG is excreted in bile; the first application of NIR imaging in liver surgery was by Ishizawa at the Tokyo Medical University who used it to visualise the biliary system.…”

Section: Intraoperative Near-infrared Imagingmentioning

confidence: 99%

Advances in resection and transplantation for hepatocellular carcinoma

Vibert

Schwartz

Olthoff

2020

Journal of Hepatology

128

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It would be impossible to summarise all of the significant developments in the surgical management of hepatocellular carcinoma (HCC), even just over the past year, in a manuscript of this scope. Thus, we have selected topics for discussion that are the subject of current controversy and have attempted to present balanced points of view. Hepatic resection and transplantation are both mature modalities, and for the most part technical advances and improvements in candidate selection are incremental. The ability to readily cure hepatitis C stands out as the most impactful development in the field over recent years, especially in Western countries where hepatitis C has long been the chief aetiology underlying HCC and a predictor of poor outcomes after surgery, but its full implications remain to be clarified. The rising incidence of non-alcoholic steatohepatitis-related HCC and what it means with regard to surgical HCC management is an area of great current interest. With advancing technology, non-surgical locoregional treatments are gaining increasing application as potentially curative therapies. In addition, the advances in molecular and genomic assessment of HCC hold promise for personalising treatment and prognostication. The possible role of immunotherapy as an adjuvant to resection is being aggressively investigated. While liver surgery maintains an important role, the care of patients with HCC is more and more a team effort and needs to take place in the context of a well-integrated interdisciplinary programme to achieve the best outcomes for patients.

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Section: Intraoperative Near-infrared Imagingmentioning

confidence: 99%

Advances in resection and transplantation for hepatocellular carcinoma

Vibert

Schwartz

Olthoff

2020

Journal of Hepatology

128

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“…There was a trend towards lower HCC recurrence and increased long‐term survival with laparoscopy. Other innovative technologies, including intra‐operative near‐infrared (NIR) imaging fluorescence‐guided surgery, are highly promising in the field of HCC . Indocyanine Green (ICG), a vital dye that is extensively used to assess liver function, binds to plasma proteins and emits light with a peak wavelength of around 830 nm when illuminated with NIR light.…”

Section: Improvement Of Curative Procedures Through Technical Innovatmentioning

confidence: 99%

“…Other innovative technologies, including intra-operative near-infrared (NIR) imaging fluorescence-guided surgery, are highly promising in the field of HCC. 17 Indocyanine Green (ICG), a vital dye that is extensively used to assess liver function, binds to plasma proteins and emits light with a peak wavelength of around 830 nm when illuminated with NIR light. ICG is excreted in bile, and tends to concentrate in HCC enabling intra-operative detection by the NIR camera.…”

Section: Advances In Surgical Treatmentsmentioning

confidence: 99%

Optimizing curative management of hepatocellular carcinoma

Nahon

Vibert

Nault

et al. 2020

Liver International

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The goal of curative management of hepatocellular carcinoma is to provide the best chance of remission. However, recurrence rates for both local and distant relapse are high. Patient subgroups at higher risk of these events can be identified based on histological patterns that are closely linked to specific molecular subtypes. Patient outcome has improved with more effective therapeutic strategies thanks to technological advances in surgical techniques and percutaneous ablation. The main goal of controlling the cause of liver disease is to decrease distant/late recurrence and prevent deterioration of hepatic function. Ongoing trials testing the combination of neoadjuvant and/or adjuvant regimens with these procedures as well as routine tumour molecular analysis may modify therapeutic algorithms for hepatocellular carcinoma in the future.

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“…Since then, more than 700 adult hepatectomy cases with the utilization of intraoperative fluorescence imaging have been reported. The target diseases have included HCC, colorectal or pancreatic liver metastasis, and intrahepatic cholangiocarcinoma, all of which are well summarized in the review article published in 2018 [11].…”

Section: Introductionmentioning

confidence: 99%

Fluorescence-Guided Surgery for Hepatoblastoma with Indocyanine Green

Yamada

Ohno

Fujino

et al. 2019

Cancers

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Fluorescence-guided surgery with indocyanine green (ICG) for malignant hepatic tumors has been gaining more attention with technical advancements. Since hepatoblastomas (HBs) possess similar features to hepatocellular carcinoma, fluorescence-guided surgery can be used for HBs, as aggressive surgical resection, even for distant metastases of HBs, often contributes positively to R0 (complete) resection and subsequent patient survival. Despite a few caveats, fluorescence-guided surgery allows for the more sensitive identification of lesions that may go undetected by conventional imaging or be invisible macroscopically. This leads to precise resection of distant metastatic tumors as well as primary liver tumors.

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Fluorescence‐guided surgery for liver tumors

Cited by 105 publications

References 40 publications

Advances in resection and transplantation for hepatocellular carcinoma

Advances in resection and transplantation for hepatocellular carcinoma

Optimizing curative management of hepatocellular carcinoma

Fluorescence-Guided Surgery for Hepatoblastoma with Indocyanine Green

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