Fluorescence‐Guided Spatial Drug Screening in 3D Colorectal Cancer Spheroids
Jia Ning Nicolette Yau,
Thirumal Yempala,
Ram Pravin Kumar Muthuramalingam
et al.
Abstract:The limited recapitulation of critical cancer features in two‐dimensional (2D) cultures causes poor translatability of preclinical results from in vitro assays to in vivo tumor models. This contributes to slow drug development with a low success rate. Three‐dimensional (3D) cultures better recapitulate the tumor microenvironment, enabling more accurate predictions when screening drug candidates and improving the development of chemotherapeutics. Platinum (Pt) (IV) compounds are promising prodrugs designed to r… Show more
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