Fluorescence enhancement of silver nanocluster at intrastrand of a 12C-loop in presence of methylated region of sept 9 promoter

Amiri‐Sadeghan, Amir; Soltaninejad, Hossein; Hosseinkhani, Saman; Hosseini, Morteza; Ganjali, Mohammad Reza; Asadollahi, Mohammad Ali

doi:10.1016/j.aca.2018.07.025

Cited by 20 publications

(11 citation statements)

References 54 publications

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“…After that, 6 μL of AgNO 3 (100 μM) was added to the mixture with vigorous vortexing and stored at 22 • C for 1 h in dark. Then, 3 μL of NaBH 4 (100 μM, ice-cold) was introduced to the solution [28].…”

Section: 4mentioning

confidence: 99%

Metal enhanced fluorescence of different metallic nanoclusters deposited on silver dendritic nanostructures

Sabzalipoor

Karimi

Nikkhah

et al. 2022

Micro & Nano Letters

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Plasmonic nanoclusters (NCs) have been introduced as new fluorescent materials that have low toxicity and do not undergo photo‐bleaching. Several factors including size and type of the NCs, surface chemistry and even solvent affect their luminescence. Despite extensive studies on tuning the fluorescence properties of NCs by manipulation of the above‐mentioned factors, very few researches have been focused on metal enhanced fluorescence (MEF) of them. In this study, the fabrication of silver dendritic nanostructured surfaces (DNSs) with numerous hotspots and unique plasmonic properties were optimized and DNSs were used as the substrates for fluorescence enhancement of NCs. NCs made of gold, silver and copper were synthesized by different stabilizing agents and compared with each other in terms of their MEF characteristics. The results showed that the stabilizing agent, the synthesis method and type of NCs affected their fluorescence enhancement by the DNSs. Copper NCs stabilized by bovine serum albumin (BSA) had the highest rate of fluorescence enhancement, with enhancement factor of 4.8 ± 0.8. Gold NCs synthesized by glutathione (GSH) and bovine serum albumin (BSA) demonstrated 3.9 ± 0.6 and 3.1 ± 0.4 fold fluorescence enhancement, respectively. The possibility of fluorescence enhancement of NCs in the vicinity of plasmonic nano‐structures introduces attractive platforms for sensing purposes.

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Section: 4mentioning

confidence: 99%

Metal enhanced fluorescence of different metallic nanoclusters deposited on silver dendritic nanostructures

Sabzalipoor

Karimi

Nikkhah

et al. 2022

Micro & Nano Letters

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“…The photoluminescence 19 of NCs that is usually fluorescence is the most widely utilized feature of NCs in sensing applications. Fluorescence decrease (turn off) 20 or enhancement (turn on) 21 , 22 , blue 23 or red 24 shift of emission peak, resonance energy transfer (FRET) 25 are the possible responses to the presence of an analyte. The specificity of these types of NC-based sensors is governed by the specific interaction of the analyte with the metallic core or the protecting ligands.…”

Section: Introductionmentioning

confidence: 99%

Phenylalanine gold nanoclusters as sensing platform for π–π interfering molecules: a case study of iodide

Amiri‐Sadeghan

Dinari

Mohammadi

et al. 2022

Sci Rep

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The photo-physical properties of metal nano clusters are sensitive to their surrounding medium. Fluorescence enhancement, quenching, and changes in the emitted photon properties are usual events in the sensing applications using these nano materials. Combining this sensitivity with unique properties of self-assembled structures opens new opportunities for sensing applications. Here, we synthesized gold nanoclusters by utilizing phenylalanine amino acid as both capping and reducing molecule. Phenylalanine is able to self-assemble to rod-shaped nano structure in which the π–π interaction between the aromatic rings is a major stabilizing force. Any substance as iodide anion or molecule that is able to weaken this interaction influence the fluorescence of metal nano-clusters. Since the building blocks of the self-assembled structure are made through the reaction of gold ions and phenylalanine, the oxidized products and their effect of sensing features are explored.

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“…The detection approach correlates with not only its metal core but also its protected ligands. Current NCs use the traditional template for synthesis like oligonucleotides, [12][13][14][15][16] proteins or peptides [17,18] and polymers (Figure 2A). Based on Watson-Crick base pairing, the oligonucleotide probe template is commonly used in microRNA or mRNA detection, specific pathogen genes or genetic disease detection, and the probes could also be employed for epigenetic detection.…”

Section: Introductionmentioning

confidence: 99%

Bridging from Metallic Nanoclusters to Biomedical in Understanding Physicochemical Interactions at the Nano–Bio Interface

Borghei

Hosseinkhani

Ganjali

2021

Part & Part Syst Charact

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many important applications. When the metal NPs size (usually 10-100 nm) is further reduced to the size comparably to the Fermi wavelength of the electron, exhibit the electronic and optical properties which can distinguish them from NPs. [1][2][3] Small NCs have no plasmonic properties (not characteristic SPR absorption peak) and due to their small size exhibit quantum confinement effects (discrete electronic energy levels, not the energy bands found in nanoparticles) and are not conductors any more. Therefore, when the NCs interact with light, they possess some electronic properties through HOMO-LUMO (highest occupied and lowest unoccupied molecular orbital) electronic transitions. [4][5][6] In this review, the properties on the basis of photoexcitation energy are divided into two categories: when the photoexcitation energy is equal to or more than the bandgap (photon energy ≥ bandgap energy) and when the photoexcitation energy is far above the ionization energies of atoms such as X-and γ-rays (photon energy ≥ bandgap energy). About the first category, it was found that the relaxation from the excited state proceeds mainly from a nonradiative (via electron injection and energy transfer) [4] or radiative (luminescence) energy transfer. [7] And the relaxation in the second category is based on secondary products generation (Figure 1).For clarity and illustrating simplicity, the biomedical applications discussed in this review are categorized based on their physicochemical properties and all of them are schematically summarized (as shown in Figure 1). For example, when discussing the enzymatic activity of NCs, it is suggested that based on this feature, these types of nanostructures are used in biomedical applications such as photodynamic therapy, infection therapy, biosensing, etc. Photon Energy ≥ Bandgap Energy Radiative DecayLuminescence: The luminescence of NCs is caused by intraband and interband electronic transitions of metal core or due to the ligand-to-metal charge transfer (LMCT) and ligand-to-metalmetal charge transfer (LMMCT) (Figure 1 1)). It is not yet well defined whether this luminescence is fluorescence (i.e., from The current review is a guideline for a physicist/chemist/biologist/physician in the introduction of metallic nanocluster (NC) applications and selection of a suitable one from a medical perspective. Metallic nanoclusters have gained attention during recent years owing to their advantages of superior optical characteristics, long lifetime, and biocompatibility for nanomedicine applications, including biolabeling, biosensing, catalysis, bioimaging, drug/ gene delivery, and therapeutic agent in comparison to the semiconductor quantum dot analogs. Here their basic physicochemical properties are being introduced, and they are linked to biomedical opportunities. Introducing the needed concepts of noble metal-based nanomaterials is being tried here, along with giving a correct comprehension of the reason for its use in a particular part of biomedical over the last 20 years. Moreover, in each ...

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Fluorescence enhancement of silver nanocluster at intrastrand of a 12C-loop in presence of methylated region of sept 9 promoter

Cited by 20 publications

References 54 publications

Metal enhanced fluorescence of different metallic nanoclusters deposited on silver dendritic nanostructures

Metal enhanced fluorescence of different metallic nanoclusters deposited on silver dendritic nanostructures

Phenylalanine gold nanoclusters as sensing platform for π–π interfering molecules: a case study of iodide

Bridging from Metallic Nanoclusters to Biomedical in Understanding Physicochemical Interactions at the Nano–Bio Interface

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