Fluorescence detection of a new photosensitizer, PAD-S31, in tumour tissues and its use as a photodynamic treatment for skin tumours in dogs and a cat: a preliminary report

Tanabe, Shigeyuki; Yamaguchi, M.; Iijima, Masayoshi; Nakajima, Susumu; Sakata, Isao; Miyaki, Sueo; Takemura, Tamiko; Furuoka, Hidefumi; Kobayashi, Yoshiyasu; Matsui, Takane; Uzuka, Yuji; Sarashina, Takao

doi:10.1016/j.tvjl.2003.07.001

Cited by 17 publications

(9 citation statements)

References 19 publications

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“…On the other hand, there are reports of PDT being used to treat spontaneous tumors in canines and felines, and the efficiency of this technique has been recognized [11,28,29,30,33,34,35]. However, the photosensitizer for PDT is very expensive and a special diode laser is needed.…”

Section: Discussionmentioning

confidence: 99%

Photodynamic hyperthermal chemotherapy with indocyanine green: a novel cancer therapy for 16 cases of malignant soft tissue sarcoma

et al. 2014

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Sixteen cases of malignant soft tissue sarcoma (STS; 10 canines and six felines) were treated with a novel triple therapy that combined photodynamic therapy, hyperthermia using indocyanine green with a broadband light source, and local chemotherapy after surgical tumor resection. This triple therapy was called photodynamic hyperthermal chemotherapy (PHCT). In all cases, the surgical margin was insufficient. In one feline case, PHCT was performed without surgical resection. PHCT was performed over an interval of 1 to 2 weeks and was repeated three to 21 times. No severe side effects, including severe skin burns, necrosis, or skin suture rupture, were observed in any of the animals. No disease recurrence was observed in seven out of 10 (70.0%) dogs and three out of six (50.0%) cats over the follow-up periods ranging from 238 to 1901 days. These results suggest that PHCT decreases the risk of STS recurrence. PHCT should therefore be considered an adjuvant therapy for treating companion animals with STS in veterinary medicine.

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Section: Discussionmentioning

confidence: 99%

Photodynamic hyperthermal chemotherapy with indocyanine green: a novel cancer therapy for 16 cases of malignant soft tissue sarcoma

et al. 2014

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“…Photodynamic therapy relies on local application of light of certain wavelengths to activate systemically delivered drugs, and has been used in MCT (EBM IV), (EBM III/IV) . Responses are reported, but treatment may precipitate degranulation, and is only suitable for relatively small superficial lesions, which are likely to be amenable to surgery.…”

Section: Canine Mctmentioning

confidence: 99%

European consensus document on mast cell tumours in dogs and cats

Blackwood

Murphy

Buracco

et al. 2012

Vet Comparative Oncology

202

356

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Statement from the Authors In preparing this document the Authors aimed to pool current information on canine and feline mast cell disease. The information was gathered from international studies and a emphasis was placed on material and opinion with a strong evidence base. We intend it to form the basis of our understanding in this disease at the current time and we anticipate that it will be particularly useful for the general practitioner. It should be emphasized that the authors are presenting this work from a European perspective.

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“…In contrast, to its increasing use in human medicine, the use of PDT in veterinary medicine has been relatively limited, and although results from small veterinary clinical studies have been published and despite the fact that the dog and cat have been used as a preclinical model in several studies (Lucroy et al, 1999, 2003b, Griffin et al, 2001, Panjehpour et al, 2002, Tanabe et al, 2004), PDT is not well established as a treatment option for tumour bearing animals to date. The main indication currently is in treatment of in situ carcinoma/SCC in cats.…”

Section: Photodynamic Therapy and Diagnosis: Clinical Uses In Humans mentioning

confidence: 99%

Photodynamic therapy and diagnosis: Principles and comparative aspects

Dobson

Queiróz

Golding

2018

The Veterinary Journal

115

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Photodynamic therapy (PDT) is an evolving method of treating superficial tumours that is non-invasive and carries minimal risk of toxicity. It combines tumour-selective photosensitiser dyes, tissue oxygen and targeted illumination to generate cytotoxic reactive oxygen species (ROS) within the tumour. In addition to directly acting on tumour cells, PDT damages and restricts tumour microvasculature, and causes a local inflammatory response that stimulates an immune response against the tumour. Unlike surgery or radiotherapy, the surrounding extracellular matrix is unaffected by PDT; thus, tissue healing is excellent and PDT seldom causes scars. This, combined with the ease of light application, has made PDT a popular treatment for cancers and pre-cancerous conditions in human beings. Moreover, because photosensitiser dyes are fluorescent and selectively accumulate in tumour tissues, they can additionally be used to visualise and discriminate tumour from normal tissues, thereby improving the accuracy of tumour surgery. In veterinary practice, PDT has been used successfully for treatment of superficial squamous cell carcinomas of the feline nasal planum; urinary tract, urinary bladder and prostate neoplasia in dogs; and equine sarcoids. The purpose of this article is to provide a comparative review of the current literature on PDT in human and veterinary medicine, and to establish a basis for future development of PDT in veterinary medicine.

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Fluorescence detection of a new photosensitizer, PAD-S31, in tumour tissues and its use as a photodynamic treatment for skin tumours in dogs and a cat: a preliminary report

Cited by 17 publications

References 19 publications

Photodynamic hyperthermal chemotherapy with indocyanine green: a novel cancer therapy for 16 cases of malignant soft tissue sarcoma

Photodynamic hyperthermal chemotherapy with indocyanine green: a novel cancer therapy for 16 cases of malignant soft tissue sarcoma

European consensus document on mast cell tumours in dogs and cats

Photodynamic therapy and diagnosis: Principles and comparative aspects

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