Fluorescence Angiography and Experimental Carotid Occlusion

Newsom, W. A.; Leverett, Sidney D.; Kirkland, Voris E.

doi:10.1001/archopht.1968.00980050379018

Archives of Ophthalmology

1968

DOI: 10.1001/archopht.1968.00980050379018

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Fluorescence Angiography and Experimental Carotid Occlusion

W. A. Newsom¹,

Sidney D. Leverett²,

Voris E. Kirkland³

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1969

1984

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Cited by 4 publications

(1 citation statement)

References 7 publications

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“…11 The term 'venous-stasis retinopathy' was used by Kearns and HollenhorstI to characterise the appearance of the retinal venous circulation in carotid occlusive disease. It consisted of dilatation and tortuosity of the major retinal veins, microaneurysms, and small punctate haemorrhages.…”

mentioning

confidence: 99%

Experimental carotid occlusion: funduscopic and fluorescein angiographic findings.

Spertus¹,

Slakter²,

Weissman³

et al. 1984

British Journal of Ophthalmology

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SUMMARY A characteristic fundus picture was consistently produced following acute bilateral common carotid artery ligation in mature rats, reminiscent of human carotid occlusive disease. Two days after ligation it consisted of dilatation and tortuosity of retinal veins, blurring and swelling of the optic disc, retinal whitening primarily along the venous distribution, and straightening of retinal arteries. Fluorescein angiography showed hyperfluorescence of the disc, delay in the rate of retinal arterial and venous filling, venous dilatation, disc oedema, disruption of the retinal capillary bed pattern, and late peripapillary staining/leakage. This pattern was not seen in rats which underwent acute unilateral ligation, although some mild changes were seen on fluorescein angiography. The vascular alterations seemed to regress spontaneously within one week. A peripapillary 'halo' and a granular-appearing nerve fibre layer developed later, exclusively in bilaterally ligated animals.Neurologists and ophthalmologists have extensively reported the signs and symptoms of carotid artery disease in humans. 11 The term 'venous-stasis retinopathy' was used by Kearns and HollenhorstI to characterise the appearance of the retinal venous circulation in carotid occlusive disease. It consisted of dilatation and tortuosity of the major retinal veins, microaneurysms, and small punctate haemorrhages. These findings were observed in approximately 5% of their patients with unilateral internal carotid artery occlusion or stenosis. They also reported sludging of blood within retinal veins in several of their patients with both carotid artery occlusion and an elevated sedimentation rate. Cotton-wool spots,23 retinal oedema,34 pale optic discs with blurred margins,4 and retinal neovascularisation4 have also been reported in patients with carotid occlusion. David etal.7 reported a delay between the retinal arterial and venous phases of fluorescein angiography during digital carotid compression in human subjects. They found that slow venous filling, in the absence of venous obstruction, was most closely correlated with insufficiency of the retinal circulation. In another fluorescein angiographic study4 one patient with bilateral common Correspondence to Paul Henkind, MD,

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mentioning

confidence: 99%

Experimental carotid occlusion: funduscopic and fluorescein angiographic findings.

Spertus¹,

Slakter²,

Weissman³

et al. 1984

British Journal of Ophthalmology

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The Retina and Optic Nerve

L'Espérance¹

1969

Archives of Ophthalmology

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An Experimental Model of Carotid Artery Occlusive Disease

Slakter¹,

Spertus²,

Weissman³

et al. 1984

American Journal of Ophthalmology

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Fluorescence Angiography and Experimental Carotid Occlusion

Cited by 4 publications

References 7 publications

Experimental carotid occlusion: funduscopic and fluorescein angiographic findings.

Experimental carotid occlusion: funduscopic and fluorescein angiographic findings.

The Retina and Optic Nerve

An Experimental Model of Carotid Artery Occlusive Disease

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