Fluorescein-Induced Allergic Reaction

López-Sáez, María Pilar; Ordoqui, E.; Tornero, Pilar; Baeza, Ana Paris de; Sainza, T.; Zubeldia, José Manuel; Baeza, M.L.

doi:10.1016/s1081-1206(10)63140-7

Cited by 105 publications

(73 citation statements)

References 7 publications

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“…OCT-A eliminates the risk and reduces the time associated with dye injections [4,5], making it more accessible for clinical use than fluorescein angiography (FA) or indocyanine green (ICG) angiography, and allowing for better visualization of retinal capillaries.…”

Section: Introductionmentioning

confidence: 99%

Projection-resolved optical coherence tomographic angiography

Zhang

Hwang

Campbell

et al. 2016

Biomed. Opt. Express

290

265

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Shadowgraphic projection artifacts from superficial vasculature interfere with the visualization of deeper vascular networks in optical coherence tomography angiography (OCT-A). We developed a novel algorithm to remove this artifact by resolving the ambiguity between in situ and projected flow signals. The algorithm identifies voxels with in situ flow as those where intensity-normalized decorrelation values are higher than all shallower voxels in the same axial scan line. This "projection-resolved" (PR) algorithm effectively suppressed the projection artifact on both en face and cross-sectional angiograms and enhanced depth resolution of vascular networks. In the human macula, the enhanced angiograms show three distinct vascular plexuses in the inner retina and no vessels in the outer retina. We demonstrate that PR OCT-A cleanly removes flow projection from the normally avascular outer retinal slab while preserving the density and continuity of the intermediate and deep retinal capillary plexuses.

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Section: Introductionmentioning

confidence: 99%

Projection-resolved optical coherence tomographic angiography

Zhang

Hwang

Campbell

et al. 2016

Biomed. Opt. Express

290

265

View full text Add to dashboard Cite

show abstract

“…Fluorescein (FA) and/or indocyanine green angiography (ICGA) have traditionally been used to detect and assess CNV in the clinic. These techniques are however 2-dimensional (2D) and involve intravenous dye injections, which can lead to nausea and anaphylaxis [6].…”

Section: Introductionmentioning

confidence: 99%

Automated choroidal neovascularization detection algorithm for optical coherence tomography angiography

Liu¹,

Gao²,

Bailey³

et al. 2015

Biomed. Opt. Express

104

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Optical coherence tomography angiography has recently been used to visualize choroidal neovascularization (CNV) in participants with age-related macular degeneration. Identification and quantification of CNV area is important clinically for disease assessment. An automated algorithm for CNV area detection is presented in this article. It relies on denoising and a saliency detection model to overcome issues such as projection artifacts and the heterogeneity of CNV. Qualitative and quantitative evaluations were performed on scans of 7 participants. Results from the algorithm agreed well with manual delineation of CNV area. ©2015 Optical Society of America

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“…However, we were unable to link this side effect to intravenous administration of the agent, as it might have served as a manifestation of general anesthesia. Mild nausea and emesis were observed in 2-10% of ophthalmologic practice cases in adults [8,9]; they appeared immediately after the agent's administration [6,10]. Other authors mentioned short-term hypotension, injection site inflammation, self-limited rash and insignificant epigastric pains in adult patients at pCLE [3].…”

Section: Resultsmentioning

confidence: 99%

Intravenous Fluorescein Administration Safety at Confocal Laser Endomicroscopy of Gastrointestinal Tract in Children

Alexandrov¹,

Шавров²,

Kharitonova³

et al. 2013

Pediatr. farmakol.

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Confocal laser endomicroscopy (CLE) is a method of optic biopsy, which allows obtaining histologic presentation of mucous tunic in real time IntroductionDetailed visualization of the digestive tract's mucous tunic is necessary for early diagnostics of a disease. Probe-based confocal laser endomicroscopy (pCLE) is a new method of gastrointestinal endoscopy, which yields images of mucous tunic of ca. 1 micron resolution and visualizes cellular and subcellular structures, capillaries and singular blood cells. The available published data indicate high interconnection of confocal endomicroscopy intravital images with the traditional histology of the unaltered digestive tract's mucous tunic [1,2]. The technique allows quickly differentiating between an inflamed, metaplastic or dysplastic mucous tunic; without any doubt, this increases interest in the use of this technique in clinical practice for diagnosis of such diseases as Barrett esophagus, gastric metaplasia of esophagus, neoplasms, inflammatory diseases of large and small intestines, Helicobacter pylori, celiac disease etc. It should be noted, that it is necessary to administer a diagnostic agent intravenously in order to obtain high-contrast images at pCLE of digestive tract. 10% sodium fluorescein solution may be used; it is widely applied in diagnostic practice in adult patients [2,3]. In 2008, the Ministry of Health of the RF approved intravenous fluorescein administration for evaluation of eye fundus condition using a confocal laser ophthalmoscope (Registration number LRS-000829/08 of 18.02.08); the procedure itself appeared to be of excellent safety level in pediatric ophthalmology [3]. This study is relevant due to the lack of direct indication in the world pediatric practice to intravenous administration of this pCLE-required diagnostic agent.

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Fluorescein-Induced Allergic Reaction

Cited by 105 publications

References 7 publications

Projection-resolved optical coherence tomographic angiography

Projection-resolved optical coherence tomographic angiography

Automated choroidal neovascularization detection algorithm for optical coherence tomography angiography

Intravenous Fluorescein Administration Safety at Confocal Laser Endomicroscopy of Gastrointestinal Tract in Children

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