Fluorene-9-bisphenol inhibits epithelial-mesenchymal transition of human endometrial cancer Ishikawa cells by repressing TGF-β signaling pathway

Bisphenol A disruption promotes mammary tumor microenvironment via phenotypic cell polarization and inflammatory response

“…Since BPA increases the expression of these proteins in epithelial cells and macrophages, the increase in M1 is probably linked to this proinflammatory cascade. We demonstrated that M1 macrophages expressed TGF-β1, a remarkable signaling molecule in BPA tumorigenesis in MG highlighted in recent studies Shen et al, 2018;Wang et al, 2019). TGF-β1 is amplified by COX-2 expression (Gan et al, 2016;Hugo et al, 2015) in addition to p-STAT3 (Clarkson et al, 2006), both high expressed in epithelial compartment in the present study.…”

Reproductive Toxicity and Teratogenicity of Fluorene-9-bisphenol on Chinese Medaka (Oryzias sinensis): A Study from Laboratory to Field

“…Experimental studies on mice found that BHPF could induce changes in reproductive and hepatic tissues in female, reduce birth weight and implantation site weight in pregnancy, and cause obvious emotional behavior changes, stillbirth, and abortion. ,− Meng et al reported that BHPF could decrease serum testosterone levels and increase the Leydig cell number and serum luteinizing hormone and follicle-stimulating hormone levels in pubertal male rats . In addition, in vitro studies showed that BHPF could inhibit maturation of mouse oocytes by reducing the protein level of p-MAPK and destroying the meiotic spindle, suppress porcine Sertoli cell proliferation and induce its apoptosis, decrease productions of aldosterone, cortisol, testosterone, and E2 by downregulation of steroidogenic genes in H295R cells through the AC/cAMP/PKA signaling pathway, and prevent proliferation of Ishikawa cells and reduce their migration and invasion abilities by repressing the TGF-beta signaling pathway. ,− Recent studies found that short-term exposure of high BHPF levels to zebrafish (Danio rerio) would induce thyroid-disrupting effects and histopathological alterations in its gill and liver tissues, disrupt myelination by affecting the hypothalamic–pituitary–thyroid axis, decrease the courtship index between female and male, fecundity, and gonadosomatic index, and cause adverse effects in oocyte maturation. − Embryonic or larval zebrafish exposed to BHPF would cause phenotypic malformation, insomnia-like behaviors, severe cardiotoxicity, mild lipid accumulation, retarded epiboly rate and growth, increased mortality, and promoted apoptosis. − However, the potential effects of long-term exposure of BHPF at low levels on fish, as well as those of BHPF contaminations in actual aquatic environments, are little known.…”

Adipocytokines and disease progression in endometrial cancer: a systematic review

“…IL-6 and TGF-β1 treatments of endometrial cancer cell lines were demonstrated to affect a decrease in epithelial marker (E cadherin) and an increase in mesenchymal markers (Twist, Snail, N-cadherin) [ 37 , 50 , 55 ]. Treatment with Chinese herbs Scutellaria baicalensis and Fritillaria cirrhosa in the study by Bokhari et al [ 53 ] and Siegesbeckia orientalis in the study by Chang et al [ 62 ] and fluorene-9-bisphenol in the study by Wang et al [ 67 ] inhibited TGF-β1-induced expression of EMT markers Snail, Slug and Focal adhesion kinase, again demonstrating, indirectly, the effect of TGF-β1 on EMT. A conference abstract [ 64 ] in the European journal of Cancer reported that GDF15 promotes endometrial cancer metastasis by EMT.…”

“…IHC ER-α Chemokine Ligand 18 (CCL18) 1. M2 macrophages treated with ER-α agonist induced EMT and promoted migration of Ishiwaka cells via CCL18 and this effect was reversed by anti-CCL18 neutralising antibody [ 67 ] Wang (2019) China Cell lines: Human endometrial cancer cell line: Ishiwaka Design: Experimental Lab methods: 1. Immunoblot 2.…”