Fluorapatite: efficient catalyst for the Michael addition

Zahouily, Mohamed; Abrouki, Younes; Rayadh, Ahmed; Sebti, Saı̈d M.; Dhimane, Hamid; David, Marc

doi:10.1016/s0040-4039(03)00323-x

Cited by 60 publications

(14 citation statements)

References 25 publications

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“…The Fluorapatite catalyst (FAP) was prepared by the co-precipitation method [11], using the following reaction: The activated Fluorapatite supported by potassium fluoride catalyst (KF/FAP) has been prepared by impregnation method [12]. The ratio of impregnation (RI) for KF/FAP catalyst was calculated according to equation (1):…”

Section: Preparation and Characterization Of Catalystsmentioning

confidence: 99%

Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride

Abrouki¹,

Anouzla²,

Loukili³

et al. 2013

AJTAS

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Abstract:The optimization of the synthesis of anti-tuberculosis drug by thia-Michael addition between thiophenol and chalcone catalyzed using activated Fluorapatite supported potassium fluoride (KF/FAP) was studied using a 2 block central composite design including 4 factors (reaction time, solvent volume, catalyst weight and impregnation ratio). The high reactivity and regioelectivity of our catalyst coupled with their ease of use and reduced environmental problems makes them attractive alternatives to homogeneous basic reagents.

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Section: Preparation and Characterization Of Catalystsmentioning

confidence: 99%

Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride

Abrouki¹,

Anouzla²,

Loukili³

et al. 2013

AJTAS

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“…Crossed-aldol condensation can be operated with the aid of strong acids or bases [2,13]. Several catalytic methods have been achieved for crossed-aldol condensation [4,[14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

New spiro (thio) barbiturates based on cyclohexanone and bicyclo [3.1.1]heptan-6-one by nonconcerted [1+5] cycloaddition reaction and their conformational structures

Pesyan¹,

Noori²,

Poorhassan³

et al. 2014

Bull. Chem. Soc. Eth.

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ABSTRACT. Crossed-aldol condensation reaction of aromatic aldehydes with ketones such as; acetone and cyclohexanone leads to the efficient formation of cross conjugated α,β-unsaturated ketones in excellent yield. The intermolecular and then intramolecular Michael addition reaction of α,β-unsaturated ketones derived from acetone and cyclohexanone with (thio)barbituric acids lead to synthesis new type of 7,11-diaryl-2,4-diazaspiro[5.5]undecane-1,3,5,9-tetraone and 2,4-diaryl-1'H-spiro[bicyclo[3.3.1]nonane-3,5'-pyrimidine]-2',4',6',9(3'H)-tetraone, respectively in good yield. Structure elucidation is carried out by 1 H NMR, 13C NMR, FT-IR, UV-Visible, mass spectroscopy and X-ray crystallography techniques. A possible mechanism of the formation is discussed. The structural conformation also demonstrated by coupling constants derived from dihedral angles between vicinal and geminal protons. The 1 H NMR spectra of NH protons of spiro compounds derived from barbituric acid show a broad singlet peak instead, these protons in the spiro compounds derived from thiobarbituric acid show two distinct peaks.

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“…Apatites are the most abundant minerals on Earth, attracting much attention for their potential applications such as catalysts [4], sensors [5], luminescence [6], ionic exchangers and biomaterials [7]. The fluoroapatite, Ca 10 (PO 4 ) 6 F 2 ( fig.1) is considered as a good structural model for apatitic compounds with space group P63/m [8,9].…”

mentioning

confidence: 99%

“…Fluorobritholite, rare-earth phosphosilicates, resulting from the substitution of the divalent cation by a trivalent rare earth element and the trivalent XO 4 group by the silicate tetravalent group (SiO 4 ), has attracted researchers interest to their potential use as oxide ion conductors or confinement matrices for the minor actinides and long-lived fission products [15][16][17]. Several studies have shown that the performance of these materials to store nuclear waste decreases with the increase of SiO 4 groups substituting PO 4 ones and the decrease of the fluorine content in the apatite framework [18,19].…”

mentioning

confidence: 99%

“…Several studies have shown that the performance of these materials to store nuclear waste decreases with the increase of SiO 4 groups substituting PO 4 ones and the decrease of the fluorine content in the apatite framework [18,19]. The stability of Fluorobritholites of general formula M 10-x La x (PO 4 ) 6-x (SiO 4 ) x F 2 (M= Ca, Sr) and Sr 7-x Ca x La 3 (PO 4 ) 3 (SiO 4 ) 3 F 2 [2,20] decrease with the increase of the substitution degree and the La atoms preferentially occupy the (6 h) sites into the apatitic structure.…”

mentioning

confidence: 99%

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Synthesis, Rietveld refinements and electrical conductivity of news fluorobritholite based on lead Ca7-xPbxLa3(PO4)3(SiO4)3F2 (0 ≤ x ≤ 2)

Moussa

Laajimi

Chaâbane

et al. 2017

Journal of Molecular Structure

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Fluorobritholites of general formula Ca 7-x Pb x La 3 (PO 4 ) 3 (SiO 4 ) 3 F 2 , (0x2) were prepared by thermal method. The obtained solid solutions were characterized by X-Ray diffraction, infrared spectroscopy and chemical analysis. The structural refinement carried out via the Rietveld method provides evidence that La 3+ and Pb 2+ substituting Ca 2+ ions are located into the two cationic sites with a strong preference for metal M(2) sites. A progressive shift of the F -ion toward the center of the triangles formed by the site M(2) metals has been observed when the lead content increased. The electrical conductivity of the fluorobritholite materials depends on the applied frequency (100 Hz -10 MHz) by means of the complex impedance spectroscopy.The effect of Pb and La-substitution on the conductivity properties of the studied fluorobritholites is correlated with Pb content. The carriers that govern the conductivity are: the nature of the welcome sites and the dimension of the tunnels.

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Fluorapatite: efficient catalyst for the Michael addition

Cited by 60 publications

References 25 publications

Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride

Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride

New spiro (thio) barbiturates based on cyclohexanone and bicyclo [3.1.1]heptan-6-one by nonconcerted [1+5] cycloaddition reaction and their conformational structures

Synthesis, Rietveld refinements and electrical conductivity of news fluorobritholite based on lead Ca7-xPbxLa3(PO4)3(SiO4)3F2 (0 ≤ x ≤ 2)

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