Flunarizine and cinnarizine-induced parkinsonism: a historical and clinical analysis

Teive, Hélio A.G.; Troiano, André R.; Germiniani, Francisco Manoel Branco; Werneck, Lineü Cesar

doi:10.1016/j.parkreldis.2003.12.004

Cited by 55 publications

(39 citation statements)

References 8 publications

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“…Although we have been discussing the possible neuroprotective effects of calcium channel blockers, curiously there is also literature on the development of drug-induced parkinsonism in the setting of current calcium channel blocker use [22] . The pathological mechanism responsible for this is still not completely understood; however, the occurrence of drug-induced parkinsonism in this setting would make it more difficult for epidemiological studies to detect a neuroprotective effect of these agents (i.e., lower risk of PD) should such an effect exist.…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive Agents and Risk of Parkinson’s Disease, Essential Tremor and Dementia: A Population-Based Prospective Study (NEDICES)

2009

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Background: Recent interest in antihypertensive agents, especially calcium channel blockers, has been sparked by the notion that these medications may be neuroprotective. A modest literature, with mixed results, has examined whether these medications might lower the odds or risk of Parkinson’s disease (PD) or dementia. There are no data for essential tremor (ET). Objective: To examine the association between antihypertensive use (defined broadly and by individual subclasses) and ET, PD and dementia. For each disorder, we used cross-sectional data (association with prevalent disease) and prospective data (association with incident disease). Methods: Prospective population-based study in Spain enrolling 5,278 participants at baseline. Results: Use of antihypertensive medications (aside from β-blockers) was similar in prevalent ET cases and controls. Baseline use of antihypertensive agents was not associated with reduced risk of incident ET. Antihypertensive medication use was not associated with prevalent or incident PD. Calcium channel blocker use was marginally reduced in prevalent dementia cases (OR_adjusted = 0.63, p = 0.06) but was not associated with reduced risk of incident dementia (RR_adjusted = 1.02, p = 0.95). Conclusions: We did not find evidence of a protective effect of antihypertensive medications in these three neurodegenerative disorders.

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Section: Discussionmentioning

confidence: 99%

Antihypertensive Agents and Risk of Parkinson’s Disease, Essential Tremor and Dementia: A Population-Based Prospective Study (NEDICES)

2009

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“…Cinnarizine sersemliğe ve görme bulanıklığına neden olduğundan, kullanıcıların iş veya trafik kazalarından korunmaları önemlidir (29). Cinnarizine'in dopamin D2 reseptörleri üzerinde antagonistik etkisi, depresyon, titreme, kas sertliği, tardif diskinezi ve akatizi semptomlarının görüldüğü, ilaç ile uyarılan Parkinson hastalığı olarak tanımlanan tabloyu oluşturan Parkinson'un ikinci önde gelen nedenlerindendir (30). Pediatrik ve erişkin birçok olguda aşırı doz cinnarizine…”

Section: üRün 3 "Ruhsatlı Sporcu Destek üRünü"unclassified

Bitkisel Ürünlerin ve Gıda Destek Ürünlerinin İçeriklerinin Adli ve Hukuki Boyutu

Türkmen¹,

Türkdoğru²,

Mercan³

et al. 2014

Bull Leg Med

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Günümüzde alternatif ya da destekleyici tedavi yöntemlerine ve bunlara bağlı olarak bitkisel ürünlere artan bir ilgi söz konusudur. Bu ürünler Gıda, Tarım ve Hayvancılık Bakanlığı’ndan gıda destek maddesi ruhsatı alınarak, “gıda takviyesi” adı altında piyasaya sürülmektedir. Bu tip ürünler ilaç statüsünde olmadığından ruhsatlandırılması ve piyasaya arzı farklılık gösterebilmektedir. Bu ürünlerle ilgili sıklıkla gözlenen sorunlar arasında kontaminasyon, katkı maddeleri, toksisite ve yanlış doz ve etiketlemeden kaynaklı tek tip üretim problemleri sayılabilir.Son zamanlarda söz konusu ürünlere ait zehirlenmeler ve ilaç etkileşimlerinin neden olduğu istenmeyen ve beklenmeyen durumlar gözlemlenmektedir. Bu gözlemler, alternatif ya da destekleyici ürün adı altında piyasaya sunulan bitkisel ürünlerin üretimi, ruhsatlandırılması, satışı ve denetimi konusunda ciddi düzenlemelere ve uygulamalara ihtiyaç olduğunu göstermektedir.Çalışmamızın amacı, laboratuarımıza içerik analizi için yönlendirilen, ikisi bakanlık onayı olmaksızın bitkisel ürün adı altında satılmakta olan, diğeri ise bakanlık onaylı sporcu destek ürünü olmak üzere üç olgudan elde edilen bulgularımızı sunmak ve ilgili olguları Türk Ceza Kanunun hükümlerine göre değerlendirmektir.Anahtar kelimeler: Bitkisel ürünler, Sibutramine, sporda kullanılan destek ürünleri, Cinnarizine, GC-MS.

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“…Although this is not exceptionally high (Bregnhøj reported prescribing of ineffective medication in 6% of all GP prescriptions 5 ), AVDs may cause serious side effects, like dystonia and parkinsonism. 6,7 Next to this, prescribing ineffective drugs may distract from the preferred approach of non-vestibular dizziness in older patients: a systematic exploration of possible contributory causes of dizziness that are amenable to treatment. 8 Reasons for irrational prescribing of AVDs may be the perceived medical need of the patient, patients' expectations, or doctor's (incorrect) perceptions of patients' expectations.…”

Section: Looks Vestibular: Irrational Prescribing Of Antivertiginous mentioning

confidence: 99%

Looks vestibular: irrational prescribing of antivertiginous drugs for older dizzy patients in general practice

Maarsingh¹,

Schellevis²,

Horst³

2012

Br J Gen Pract

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Flunarizine and cinnarizine-induced parkinsonism: a historical and clinical analysis

Cited by 55 publications

References 8 publications

Antihypertensive Agents and Risk of Parkinson’s Disease, Essential Tremor and Dementia: A Population-Based Prospective Study (NEDICES)

Antihypertensive Agents and Risk of Parkinson’s Disease, Essential Tremor and Dementia: A Population-Based Prospective Study (NEDICES)

Bitkisel Ürünlerin ve Gıda Destek Ürünlerinin İçeriklerinin Adli ve Hukuki Boyutu

Looks vestibular: irrational prescribing of antivertiginous drugs for older dizzy patients in general practice

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