Fluidity of the dietary fatty acid profile and risk of coronary heart disease and ischemic stroke: Results from the EPIC-Netherlands cohort study

Sluijs, Ivonne; Praagman, Jaike; Boer, Jolanda M. A.; Schouw, Yvonne T. van der

doi:10.1016/j.numecd.2017.06.008

Cited by 8 publications

(4 citation statements)

References 17 publications

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“…On the other hand, in our study, anxiety, and stress did not show a significant association with any of the LI or LL. This is consistent with some previous studies, such as the study by Sluijs et al, Which displayed that dietary LI was not associated with the odds of CHD and ischemic stroke [ 17 ].…”

Section: Discussionsupporting

confidence: 93%

“…Toledo et al, also found that an increase in dietary LI was linked to an increase in plasma TG, 9 a higher ratio of LDL 10 to HDL, 11 and risk of myocardial infarction (in the highest quintile of the dietary LI) [ 16 ]. On the other hand, Sluijs et al In Italy demonstrated that dietary lipophilic load (LL) and index were not associated with CHD and ischemic stroke [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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The relationship between dietary lipophilic index and load with depression, anxiety, and stress symptoms

Barzegaran,

Jazayeri,

Abolghasemi

et al. 2023

BMC Psychiatry

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Background Dietary fatty acids can affect brain health by modifying neuronal membrane fluidity. Dietary lipophilic index (LI) and load (LL) may be related to cell membrane fluidity. This study aimed to determine the relationship between dietary LI and LL with symptoms of depression, anxiety and stress. Methods In this cross-sectional study, taken from the YaHS (Yazd Health Study) population-based cohort, the data of 2,982 individuals was extracted. Several questionnaires- a 178-item Food Frequency Questionnaire (FFQ), Depression, Anxiety and Stress Scale 21 (DASS 21), and International Physical Activity Questionnaire (IPAQ)- were used to obtain information on dietary intake, mental status, and physical activity, respectively. LI and LL were calculated using dietary intake and the melting point of each fatty acid. Results The analysis was performed on 2982 individuals. The odds ratio of depression in the second tertile of dietary LI compared to the first tertile was 0.815 (95% CI 0.66–1.00, P = 0.051, Ptrend = 0.017) and after adjusting confounders was 0.793 (95% CI 0.63–0.99, P = 0.043, Ptrend = 0.011). Also, LL was related inversely with anxiety (0.771, 95% CI 0.63–0.93, P = 0.003) that after multiple regression, OR of anxiety was 0.762 (95% CI 0.53–1.07, P = 0.045). The odds of stress in the third tertile of LL was 1.064 but not statistically significant (95% CI 0.88–1.28, P = 0.729). Conclusion This study showed an inverse association between dietary LI and depression symptoms. Anxiety and stress did not show a significant relationship with LI or LL.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

The relationship between dietary lipophilic index and load with depression, anxiety, and stress symptoms

Barzegaran,

Jazayeri,

Abolghasemi

et al. 2023

BMC Psychiatry

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“…Only a few other studies regarding the lipophilic index and cardiovascular disease have been published previously. In a case-cohort study of a Dutch population including 2604 subjects and 479 cases with ischemic stroke, no association between the dietary lipophilic index and ischemic stroke or coronary heart disease was found [ 28 ], which is in line with our results. The authors explained the neutral results by little variation in the intake of polyunsaturated fatty acids and a low intake of omega-3 fatty acids within the study population, which are known to be associated with lower risk of cardiovascular disease.…”

Section: Discussionsupporting

confidence: 91%

“…The authors explained the neutral results by little variation in the intake of polyunsaturated fatty acids and a low intake of omega-3 fatty acids within the study population, which are known to be associated with lower risk of cardiovascular disease. Furthermore, a high dietary lipophilic index was found to be correlated with higher intakes of saturated and trans fatty acids and lower intake of polyunsaturated fatty acids, suggesting that the lipophilic index reflected the quality of dietary fats [ 28 ]. Since our study investigated the same outcome, this may indicate that neither the adipose tissue lipophilic index nor dietary lipophilic index is associated with ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%

Adipose Tissue Lipophilic Index and Risk of Ischemic Stroke—A Danish Case-Cohort Study

et al. 2018

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Diet may influence the risk of ischemic stroke by several mechanisms. A potential and hitherto unknown mechanism may relate to an effect on the lipophilic index, which is a new and convenient indicator of membrane fluidity. This study investigated the association between the adipose tissue lipophilic index and ischemic stroke and its subtypes. A case-cohort study was conducted based on the Danish cohort study Diet, Cancer, and Health, which includes 57,053 subjects aged 50–64 years at enrolment. A subcohort (n = 3500) was randomly drawn from the whole cohort. All ischemic stroke cases were validated and categorized into subtypes. The lipophilic index was calculated based on fatty acid profiles in adipose tissue. Subjects were divided into quintiles and a weighted Cox proportional hazards regression model was used to calculate hazard ratios. After appropriate exclusions, a subcohort of 3194 subjects and 1752 cases of ischemic stroke were included. When comparing the fifth quintile of the lipophilic index with the first quintile, the hazard ratio for ischemic stroke was 0.92 (95% confidence interval 0.75, 1.13) and the trend across quintiles was not statistically significant (p = 0.1727). In conclusion, no association was found between the lipophilic index and ischemic stroke or its subtypes.

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The melting point of dietary fatty acids is a key regulator of omega-3 fatty acid metabolism in Atlantic salmon

Turchini,

Conlan,

Emery

et al. 2024

Aquaculture

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Fluidity of the dietary fatty acid profile and risk of coronary heart disease and ischemic stroke: Results from the EPIC-Netherlands cohort study

Cited by 8 publications

References 17 publications

The relationship between dietary lipophilic index and load with depression, anxiety, and stress symptoms

The relationship between dietary lipophilic index and load with depression, anxiety, and stress symptoms

Adipose Tissue Lipophilic Index and Risk of Ischemic Stroke—A Danish Case-Cohort Study

The melting point of dietary fatty acids is a key regulator of omega-3 fatty acid metabolism in Atlantic salmon

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