Fluidic enabled bioelectronic implants: opportunities and challenges

Coles, Lawrence; Oluwasanya, Pelumi W.; Karam, Nuzli; Proctor, Christopher M.

doi:10.1039/d2tb00942k

Cited by 4 publications

(4 citation statements)

References 105 publications

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“…Organic bioelectronics have emerged as a promising technology in medical diagnostics, thus offering unique advantages for noninvasive and point-of-care testing. By leveraging organic materials' electrical and biological properties, organic bioelectronics facilitates the development of sensitive, portable, and cost-effective diagnostic devices [195][196][197].…”

Section: Biosensing Applications 61 Medical Diagnosticsmentioning

confidence: 99%

Organic Electronics in Biosensing: A Promising Frontier for Medical and Environmental Applications

Kaushal,

Raut,

Kumar

2023

Biosensors

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The promising field of organic electronics has ushered in a new era of biosensing technology, thus offering a promising frontier for applications in both medical diagnostics and environmental monitoring. This review paper provides a comprehensive overview of organic electronics’ remarkable progress and potential in biosensing applications. It explores the multifaceted aspects of organic materials and devices, thereby highlighting their unique advantages, such as flexibility, biocompatibility, and low-cost fabrication. The paper delves into the diverse range of biosensors enabled by organic electronics, including electrochemical, optical, piezoelectric, and thermal sensors, thus showcasing their versatility in detecting biomolecules, pathogens, and environmental pollutants. Furthermore, integrating organic biosensors into wearable devices and the Internet of Things (IoT) ecosystem is discussed, wherein they offer real-time, remote, and personalized monitoring solutions. The review also addresses the current challenges and future prospects of organic biosensing, thus emphasizing the potential for breakthroughs in personalized medicine, environmental sustainability, and the advancement of human health and well-being.

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Section: Biosensing Applications 61 Medical Diagnosticsmentioning

confidence: 99%

Organic Electronics in Biosensing: A Promising Frontier for Medical and Environmental Applications

Kaushal,

Raut,

Kumar

2023

Biosensors

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“…Chemical delivery is an important basic operation in various biomedical fields, including in vitro cell‐based assays for drug development and in vivo drug administration using implanted and wearable devices. [ 1–5 ] Passive diffusion‐based delivery devices offer a simple but uncontrollable approach characterized by the initial burst release of chemical drugs at high concentrations. [ 6,7 ] The conventional controllable delivery system employs pressure‐driven microfluidics that apply water pressure to the nozzle of microchannels using an external pressure pump.…”

Section: Introductionmentioning

confidence: 99%

“…[ 8–10 ] The medical devices including the chemical delivery devices are increasingly composed of soft and flexible materials to better match the mechanical properties of surrounding tissues. [ 3 ] However, in practice, it is difficult to instantaneously transmit pressure through a flexible soft microchannel, causing lower controllability in chemical delivery. Therefore, electrical pump systems based on electrophoresis or electroosmosis have been actively investigated for the controlled delivery of small amounts of chemicals into a target microspace.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, electrical pump systems based on electrophoresis or electroosmosis have been actively investigated for the controlled delivery of small amounts of chemicals into a target microspace. [ 3 ] For example, the organic electronic ion pumps (OEIPs) [ 11,12 ] based on the electrophoresis of drug itself have been developed, and successfully applied in vitro [ 13,14 ] and in vivo. [ 15–18 ] A significant advantage of OEIPs is the minimization of liquid flow that could interfere with the biochemical microenvironment.…”

Section: Introductionmentioning

confidence: 99%

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Spatiotemporally Controllable Chemical Delivery Utilizing Electroosmotic Flow Generated in Combination of Anionic and Cationic Hydrogels

Terutsuki,

Miyazawa,

Takagi

et al. 2023

Adv Funct Materials

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Spatiotemporally controlled chemical delivery is crucial for various biomedical engineering applications. Here, a novel concept of electrically controllable delivery utilizing electroosmotic flow (EOF) generated in a combination of anionic and cationic hydrogels (A‐ and C‐hydrogels) is reported. The unique advantages of the A/C‐hydrogel combination are demonstrated utilizing a flexible sheet‐shaped and a thin tubular devices. Since the directions of EOF in the A‐ and C‐hydrogels are opposite to each other, the ionic current for EOF generation flows inside the delivery devices, enabling chemical delivery without accompanying external ionic current that could stimulate target cells and tissues. A thin tubular device, which can be inserted into narrow in vivo structures and be integrated with other flexible devices, exhibits high robustness and repeatability thanks to the flexibility and water retentivity of hydrogels. The EOF devices with A/C‐hydrogels combination show high controllability superior to the pumping with a conventional syringe; the volumetric flow rate is able to be controlled proportionally to the current applied, for example, ≈0.4 µL (mA min)−1 for the tubular device. The developed EOF‐based devices are versatile for delivery of most chemicals regardless of their charge and size, and have great potential for both biomedical researches and therapeutics.

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Bioinspired nanoplatforms for human-machine interfaces: Recent progress in materials and device applications

Sayyad,

Park,

2024

Biotechnology Advances

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Fluidic enabled bioelectronic implants: opportunities and challenges

Abstract: Fluidics are enabling new possibilities in bioelectronic medicine and research.

Cited by 4 publications

References 105 publications

Organic Electronics in Biosensing: A Promising Frontier for Medical and Environmental Applications

Organic Electronics in Biosensing: A Promising Frontier for Medical and Environmental Applications

Spatiotemporally Controllable Chemical Delivery Utilizing Electroosmotic Flow Generated in Combination of Anionic and Cationic Hydrogels

Bioinspired nanoplatforms for human-machine interfaces: Recent progress in materials and device applications

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